{"id":{"repo_id":"unlv","oai_identifier":"oai:oasis.library.unlv.edu:rtds-1284"},"canonical_url":"https://search.dev.ndltd.org/etd/unlv/oai:oasis.library.unlv.edu:rtds-1284","repository":{"repo_id":"unlv","name":"University of Nevada - Las Vegas","base_url":"https://oasis.library.unlv.edu/do/oai/"},"display":{"title":"Evaluation of selected aliphatic acids and polytetrahydrofurans for use as calibration agents for thermospray Hplc/Ms","abstract":"A method of tuning and calibration for a thermospray ion source on a benchtop quadrupole mass spectrometer using trifluoroacetic acid, pentafluoropropionic acid, heptafluorobutyric acid, polytetrahydrofuran-250, and polytetrahydrofuran-650 was proposed and evaluated. A 0.5% solution of the aliphatic acids showed good mass range coverage (163-641) in the negative mode, and no substantial memory effects. This mixture was evaluated over 45 days for fluctuations in the ion intensities and ratios. It remained stable within the expected thermospray reproducibility range, although the volatility of the trifluoroacetic acid made daily preparation of standard mixtures necessary. A similar solution of the polytetrahydrofurans was evaluated in both the positive and the negative ionization mode. While several high mass ions were identified in the resulting spectra, these compounds lacked the reproducibility and predictability required, and were dropped from further evaluation.","abstract_html":"A method of tuning and calibration for a thermospray ion source on a benchtop quadrupole mass spectrometer using trifluoroacetic acid, pentafluoropropionic acid, heptafluorobutyric acid, polytetrahydrofuran-250, and polytetrahydrofuran-650 was proposed and evaluated. A 0.5% solution of the aliphatic acids showed good mass range coverage (163-641) in the negative mode, and no substantial memory effects. This mixture was evaluated over 45 days for fluctuations in the ion intensities and ratios. It remained stable within the expected thermospray reproducibility range, although the volatility of the trifluoroacetic acid made daily preparation of standard mixtures necessary. A similar solution of the polytetrahydrofurans was evaluated in both the positive and the negative ionization mode. While several high mass ions were identified in the resulting spectra, these compounds lacked the reproducibility and predictability required, and were dropped from further evaluation.","abstract_has_math":false,"creators":["Dombrowski, Tonya Rose"],"institution":"University of Nevada, Las Vegas","degree_name":"Master of Science (MS)","degree_level":"Thesis","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Vernon Hodge"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1993,"date_issued":"1993-01-01T08:00:00Z","date_published":"1993-01-01T08:00:00Z","updated_at":"2026-07-24T05:24:22Z","subjects":[],"languages":["English"],"rights":["IN COPYRIGHT. For more information about this rights statement, please visit http://rightsstatements.org/vocab/InC/1.0/"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["https://oasis.library.unlv.edu/rtds/285"],"render_values":[{"text":"https://oasis.library.unlv.edu/rtds/285","href":"https://oasis.library.unlv.edu/rtds/285","code":true}]}]},"links":{"outbound_url":"https://doi.org/10.25669/qeqs-5bs1","outbound_label":"DOI","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Vernon Hodge"]},{"key":"dc:creator","label":"Author","values":["Dombrowski, Tonya Rose"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:publisher","label":"Institution","values":["University of Nevada, Las Vegas"]},{"key":"dc:type","label":"Dc Type","values":["Text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science (MS)"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]},{"key":"dc:rights","label":"Dc Rights","values":["IN COPYRIGHT. For more information about this rights statement, please visit http://rightsstatements.org/vocab/InC/1.0/"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.25669/qeqs-5bs1","https://oasis.library.unlv.edu/rtds/285","https://oasis.library.unlv.edu/context/rtds/article/1284/viewcontent/uc.pdf"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["A method of tuning and calibration for a thermospray ion source on a benchtop quadrupole mass spectrometer using trifluoroacetic acid, pentafluoropropionic acid, heptafluorobutyric acid, polytetrahydrofuran-250, and polytetrahydrofuran-650 was proposed and evaluated. A 0.5% solution of the aliphatic acids showed good mass range coverage (163-641) in the negative mode, and no substantial memory effects. This mixture was evaluated over 45 days for fluctuations in the ion intensities and ratios. It remained stable within the expected thermospray reproducibility range, although the volatility of the trifluoroacetic acid made daily preparation of standard mixtures necessary. A similar solution of the polytetrahydrofurans was evaluated in both the positive and the negative ionization mode. While several high mass ions were identified in the resulting spectra, these compounds lacked the reproducibility and predictability required, and were dropped from further evaluation."]},{"key":"dc:format","label":"Dc Format","values":["pdf"]},{"key":"dc:title","label":"Title","values":["Evaluation of selected aliphatic acids and polytetrahydrofurans for use as calibration agents for thermospray Hplc/Ms"]}]}],"canonical_facts":{"dc:contributor":["Vernon Hodge"],"dc:creator":["Dombrowski, Tonya Rose"],"dc:description.abstract":["A method of tuning and calibration for a thermospray ion source on a benchtop quadrupole mass spectrometer using trifluoroacetic acid, pentafluoropropionic acid, heptafluorobutyric acid, polytetrahydrofuran-250, and polytetrahydrofuran-650 was proposed and evaluated. A 0.5% solution of the aliphatic acids showed good mass range coverage (163-641) in the negative mode, and no substantial memory effects. This mixture was evaluated over 45 days for fluctuations in the ion intensities and ratios. It remained stable within the expected thermospray reproducibility range, although the volatility of the trifluoroacetic acid made daily preparation of standard mixtures necessary. A similar solution of the polytetrahydrofurans was evaluated in both the positive and the negative ionization mode. While several high mass ions were identified in the resulting spectra, these compounds lacked the reproducibility and predictability required, and were dropped from further evaluation."],"dc:format":["pdf"],"dc:identifier":["10.25669/qeqs-5bs1","https://oasis.library.unlv.edu/rtds/285","https://oasis.library.unlv.edu/context/rtds/article/1284/viewcontent/uc.pdf"],"dc:language":["English"],"dc:publisher":["University of Nevada, Las Vegas"],"dc:rights":["IN COPYRIGHT. For more information about this rights statement, please visit http://rightsstatements.org/vocab/InC/1.0/"],"dc:title":["Evaluation of selected aliphatic acids and polytetrahydrofurans for use as calibration agents for thermospray Hplc/Ms"],"dc:type":["Text"],"thesis:degree_discipline":["Chemistry"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["Master of Science (MS)"]},"updated_at":"2026-07-24T05:24:22Z"}