Experiment 1 examined the alloantigen system L effects on Rous sarcomas in three B complex genotypes. The parental stock were 50% Modified Wisconsin Line 3 and 50% inbred Line 6.15- 5. B2B5 L1L2 x B2B5 L 1L2 matings produced experimental chicks. Chicks were inoculated with 20 pock-forming units (pfu) Rous sarcoma virus (RSV) at 6 weeks-of-age. Tumors were scored six times over 10 weeks postinoculation. Tumor scores were used to assign a tumor profile index (TPI) to each chicken. Results were evaluated by ANOVA. The B complex affected the responses. Separate analyses revealed L system effects ( P < 0.05) only in B5B 5 chickens.
Experiment 2 examined the influence of Ea-L on antibody response to SRBC and Brucella abortus (BA). The mating protocol was the same as in Experiment 1. At 4 and 11 weeks of age the experimental birds were injected intravenously with standard concentrations of SRBC and BA. Total and ME-resistant antibody titers were determined as described. Results were analyzed by ANOVA. Ea-L had an effect on total primary antibody titer to SRBC in a B5B 5 background (p < 0.004) and on total (p < 0.011) and ME-resistant (p < 0.017) secondary titer to SRBC in a B5 B5 genotypic background. Ea-L also affected total (p < 0.004) and ME-resistant (p < 0.005) secondary titer to Brucella abortus in a B5 B5 background.
Experiment 3 examined the effect of Ea-L on resistance and acquired immunity to E. tenella infection. The mating protocol was the same as in Experiments 1 and 2. In the resistance and susceptibility study, chicks were weighed and inoculated with 30,000 E. tenella oocysts at 6 weeks of age. 6 days post-inoculation, the birds were weighed again and assigned a cecal lesion score. In the immunity study, the challenge procedure was preceded by inoculations of 500 oocysts per day beginning at 5 weeks. Weight gain and cecal lesion scores were evaluated by ANOVA. The B complex affected lesion score in the immunity but not the resistance and susceptibility study and did not affect weight gain in either study. The L system had no effect in either study.
","abstract_html":"<p>Experiment 1 examined the alloantigen system L effects on Rous sarcomas in three B complex genotypes. The parental stock were 50% Modified Wisconsin Line 3 and 50% inbred Line 6.15- 5. B2B5 L1L2 x B2B5 L 1L2 matings produced experimental chicks. Chicks were inoculated with 20 pock-forming units (pfu) Rous sarcoma virus (RSV) at 6 weeks-of-age. Tumors were scored six times over 10 weeks postinoculation. Tumor scores were used to assign a tumor profile index (TPI) to each chicken. Results were evaluated by ANOVA. The B complex affected the responses. Separate analyses revealed L system effects ( P < 0.05) only in B5B 5 chickens.</p><p>Experiment 2 examined the influence of Ea-L on antibody response to SRBC and Brucella abortus (BA). The mating protocol was the same as in Experiment 1. At 4 and 11 weeks of age the experimental birds were injected intravenously with standard concentrations of SRBC and BA. Total and ME-resistant antibody titers were determined as described. Results were analyzed by ANOVA. Ea-L had an effect on total primary antibody titer to SRBC in a B5B 5 background (p < 0.004) and on total (p < 0.011) and ME-resistant (p < 0.017) secondary titer to SRBC in a B5 B5 genotypic background. Ea-L also affected total (p < 0.004) and ME-resistant (p < 0.005) secondary titer to Brucella abortus in a B5 B5 background.</p><p>Experiment 3 examined the effect of Ea-L on resistance and acquired immunity to E. tenella infection. The mating protocol was the same as in Experiments 1 and 2. In the resistance and susceptibility study, chicks were weighed and inoculated with 30,000 E. tenella oocysts at 6 weeks of age. 6 days post-inoculation, the birds were weighed again and assigned a cecal lesion score. In the immunity study, the challenge procedure was preceded by inoculations of 500 oocysts per day beginning at 5 weeks. Weight gain and cecal lesion scores were evaluated by ANOVA. The B complex affected lesion score in the immunity but not the resistance and susceptibility study and did not affect weight gain in either study. The L system had no effect in either study.</p>","abstract_has_math":false,"creators":["Medarova, Zdravka Ognyanova"],"institution":null,"degree_name":"Doctor of Philosophy","degree_level":"Dissertation","degree_discipline":null,"degree_department":null,"school":null,"contributors":["Robert L Taylor, Jr"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2002,"date_issued":"2002-01-01T08:00:00Z","date_published":"2002-01-01T08:00:00Z","updated_at":"2026-07-24T05:22:01Z","subjects":["Biology","Genetics"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://scholars.unh.edu/dissertation/108","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Robert L Taylor, Jr"]},{"key":"dc:creator","label":"Author","values":["Medarova, Zdravka Ognyanova"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Doctor of Philosophy"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology","Genetics"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://scholars.unh.edu/dissertation/108"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Experiment 1 examined the alloantigen system L effects on Rous sarcomas in three B complex genotypes. The parental stock were 50% Modified Wisconsin Line 3 and 50% inbred Line 6.15- 5. B2B5 L1L2 x B2B5 L 1L2 matings produced experimental chicks. Chicks were inoculated with 20 pock-forming units (pfu) Rous sarcoma virus (RSV) at 6 weeks-of-age. Tumors were scored six times over 10 weeks postinoculation. Tumor scores were used to assign a tumor profile index (TPI) to each chicken. Results were evaluated by ANOVA. The B complex affected the responses. Separate analyses revealed L system effects ( P < 0.05) only in B5B 5 chickens.
Experiment 2 examined the influence of Ea-L on antibody response to SRBC and Brucella abortus (BA). The mating protocol was the same as in Experiment 1. At 4 and 11 weeks of age the experimental birds were injected intravenously with standard concentrations of SRBC and BA. Total and ME-resistant antibody titers were determined as described. Results were analyzed by ANOVA. Ea-L had an effect on total primary antibody titer to SRBC in a B5B 5 background (p < 0.004) and on total (p < 0.011) and ME-resistant (p < 0.017) secondary titer to SRBC in a B5 B5 genotypic background. Ea-L also affected total (p < 0.004) and ME-resistant (p < 0.005) secondary titer to Brucella abortus in a B5 B5 background.
Experiment 3 examined the effect of Ea-L on resistance and acquired immunity to E. tenella infection. The mating protocol was the same as in Experiments 1 and 2. In the resistance and susceptibility study, chicks were weighed and inoculated with 30,000 E. tenella oocysts at 6 weeks of age. 6 days post-inoculation, the birds were weighed again and assigned a cecal lesion score. In the immunity study, the challenge procedure was preceded by inoculations of 500 oocysts per day beginning at 5 weeks. Weight gain and cecal lesion scores were evaluated by ANOVA. The B complex affected lesion score in the immunity but not the resistance and susceptibility study and did not affect weight gain in either study. The L system had no effect in either study.
"]},{"key":"dc:title","label":"Title","values":["The effects of erythrocyte alloantigen L on the avian immune response"]}]}],"canonical_facts":{"dc:contributor":["Robert L Taylor, Jr"],"dc:creator":["Medarova, Zdravka Ognyanova"],"dc:description.abstract":["Experiment 1 examined the alloantigen system L effects on Rous sarcomas in three B complex genotypes. The parental stock were 50% Modified Wisconsin Line 3 and 50% inbred Line 6.15- 5. B2B5 L1L2 x B2B5 L 1L2 matings produced experimental chicks. Chicks were inoculated with 20 pock-forming units (pfu) Rous sarcoma virus (RSV) at 6 weeks-of-age. Tumors were scored six times over 10 weeks postinoculation. Tumor scores were used to assign a tumor profile index (TPI) to each chicken. Results were evaluated by ANOVA. The B complex affected the responses. Separate analyses revealed L system effects ( P < 0.05) only in B5B 5 chickens.
Experiment 2 examined the influence of Ea-L on antibody response to SRBC and Brucella abortus (BA). The mating protocol was the same as in Experiment 1. At 4 and 11 weeks of age the experimental birds were injected intravenously with standard concentrations of SRBC and BA. Total and ME-resistant antibody titers were determined as described. Results were analyzed by ANOVA. Ea-L had an effect on total primary antibody titer to SRBC in a B5B 5 background (p < 0.004) and on total (p < 0.011) and ME-resistant (p < 0.017) secondary titer to SRBC in a B5 B5 genotypic background. Ea-L also affected total (p < 0.004) and ME-resistant (p < 0.005) secondary titer to Brucella abortus in a B5 B5 background.
Experiment 3 examined the effect of Ea-L on resistance and acquired immunity to E. tenella infection. The mating protocol was the same as in Experiments 1 and 2. In the resistance and susceptibility study, chicks were weighed and inoculated with 30,000 E. tenella oocysts at 6 weeks of age. 6 days post-inoculation, the birds were weighed again and assigned a cecal lesion score. In the immunity study, the challenge procedure was preceded by inoculations of 500 oocysts per day beginning at 5 weeks. Weight gain and cecal lesion scores were evaluated by ANOVA. The B complex affected lesion score in the immunity but not the resistance and susceptibility study and did not affect weight gain in either study. The L system had no effect in either study.
"],"dc:identifier":["https://scholars.unh.edu/dissertation/108"],"dc:subject":["Biology","Genetics"],"dc:title":["The effects of erythrocyte alloantigen L on the avian immune response"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Doctor of Philosophy"]},"updated_at":"2026-07-24T05:22:01Z"}