{"id":{"repo_id":"umn","oai_identifier":"oai:conservancy.umn.edu:11299/60691"},"canonical_url":"https://search.dev.ndltd.org/etd/umn/oai:conservancy.umn.edu:11299/60691","repository":{"repo_id":"umn","name":"University of Minnesota","base_url":"https://conservancy.umn.edu/server/oai/request"},"display":{"title":"Optimized pulsing of high-intensity focused ultrasound for enhanced therapeutic window","abstract":"High intensity focused ultrasound (HIFU) provides a unique modality to perform non-invasive surgeries. The thermal ablation technique relies on focusing the non-ionizing acoustic wave within soft tissues to produce a small lesion. HIFU operations are typically attempted by continuous-wave (CW) applications of the beam intervened by wait periods to allow surrounding tissue to cool down. Large contiguous lesions are produced by raster-scanning the beam over the volume of the tumor; a procedure that requires up to three hours for a 2-cm diameter tumor. This is one of the main limitations of HIFU thermal therapy. As part of the ongoing research to accelerate the procedure, we investigate the role of pulsed-HIFU (pHIFU) parameters in the enhancement of the therapeutic gain within the HIFU focus. A therapeutic gain is observed when high duty cycle pHIFU is pulsed at the mechanical resonance of the medium. Up to 50% increase in temperature was measured in lab-prepared tissue mimicking phantoms. The therapeutic gain achieved by pHIFU over cwHIFU is attractive as no modifications on the currently used applicators are required.","abstract_html":"High intensity focused ultrasound (HIFU) provides a unique modality to perform non-invasive surgeries. The thermal ablation technique relies on focusing the non-ionizing acoustic wave within soft tissues to produce a small lesion. HIFU operations are typically attempted by continuous-wave (CW) applications of the beam intervened by wait periods to allow surrounding tissue to cool down. Large contiguous lesions are produced by raster-scanning the beam over the volume of the tumor; a procedure that requires up to three hours for a 2-cm diameter tumor. This is one of the main limitations of HIFU thermal therapy. As part of the ongoing research to accelerate the procedure, we investigate the role of pulsed-HIFU (pHIFU) parameters in the enhancement of the therapeutic gain within the HIFU focus. A therapeutic gain is observed when high duty cycle pHIFU is pulsed at the mechanical resonance of the medium. Up to 50% increase in temperature was measured in lab-prepared tissue mimicking phantoms. The therapeutic gain achieved by pHIFU over cwHIFU is attractive as no modifications on the currently used applicators are required.","abstract_has_math":false,"creators":["Al-Qaisi, Muhammad K."],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2010,"date_issued":"2010-03","date_published":"2010-03","updated_at":"2026-07-24T05:19:56Z","subjects":["Therapeutic gain","HIFU","Continuous-wave","Temperature","Biomedical Engineering"],"languages":["en_US"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://purl.umn.edu/60691","outbound_label":"Repository record","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Al-Qaisi, Muhammad K."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2010-04-19T15:38:59Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2010-04-19T15:38:59Z"]},{"key":"dc:date.issued","label":"Date","values":["2010-03"]},{"key":"dc:type","label":"Dc Type","values":["Thesis or Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Therapeutic gain","HIFU","Continuous-wave","Temperature","Biomedical Engineering"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_US"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://purl.umn.edu/60691"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["University of Minnesota. M.S. thesis. March 2010. Major: Biomedical engineering. Advisor:Emad Ebbini. 1 computer file (PDF)); v, 37 pages. Ill. (some col.)"]},{"key":"dc:description.abstract","label":"Abstract","values":["High intensity focused ultrasound (HIFU) provides a unique modality to perform non-invasive surgeries. The thermal ablation technique relies on focusing the non-ionizing acoustic wave within soft tissues to produce a small lesion. HIFU operations are typically attempted by continuous-wave (CW) applications of the beam intervened by wait periods to allow surrounding tissue to cool down. Large contiguous lesions are produced by raster-scanning the beam over the volume of the tumor; a procedure that requires up to three hours for a 2-cm diameter tumor. This is one of the main limitations of HIFU thermal therapy. As part of the ongoing research to accelerate the procedure, we investigate the role of pulsed-HIFU (pHIFU) parameters in the enhancement of the therapeutic gain within the HIFU focus. A therapeutic gain is observed when high duty cycle pHIFU is pulsed at the mechanical resonance of the medium. Up to 50% increase in temperature was measured in lab-prepared tissue mimicking phantoms. The therapeutic gain achieved by pHIFU over cwHIFU is attractive as no modifications on the currently used applicators are required."]},{"key":"dc:title","label":"Title","values":["Optimized pulsing of high-intensity focused ultrasound for enhanced therapeutic window"]}]}],"canonical_facts":{"dc:creator":["Al-Qaisi, Muhammad K."],"dc:date.accessioned":["2010-04-19T15:38:59Z"],"dc:date.available":["2010-04-19T15:38:59Z"],"dc:date.issued":["2010-03"],"dc:description":["University of Minnesota. M.S. thesis. March 2010. Major: Biomedical engineering. Advisor:Emad Ebbini. 1 computer file (PDF)); v, 37 pages. Ill. (some col.)"],"dc:description.abstract":["High intensity focused ultrasound (HIFU) provides a unique modality to perform non-invasive surgeries. The thermal ablation technique relies on focusing the non-ionizing acoustic wave within soft tissues to produce a small lesion. HIFU operations are typically attempted by continuous-wave (CW) applications of the beam intervened by wait periods to allow surrounding tissue to cool down. Large contiguous lesions are produced by raster-scanning the beam over the volume of the tumor; a procedure that requires up to three hours for a 2-cm diameter tumor. This is one of the main limitations of HIFU thermal therapy. As part of the ongoing research to accelerate the procedure, we investigate the role of pulsed-HIFU (pHIFU) parameters in the enhancement of the therapeutic gain within the HIFU focus. A therapeutic gain is observed when high duty cycle pHIFU is pulsed at the mechanical resonance of the medium. Up to 50% increase in temperature was measured in lab-prepared tissue mimicking phantoms. The therapeutic gain achieved by pHIFU over cwHIFU is attractive as no modifications on the currently used applicators are required."],"dc:identifier.uri":["http://purl.umn.edu/60691"],"dc:language.iso":["en_US"],"dc:subject":["Therapeutic gain","HIFU","Continuous-wave","Temperature","Biomedical Engineering"],"dc:title":["Optimized pulsing of high-intensity focused ultrasound for enhanced therapeutic window"],"dc:type":["Thesis or Dissertation"]},"updated_at":"2026-07-24T05:19:56Z"}