{"id":{"repo_id":"umn","oai_identifier":"oai:conservancy.umn.edu:11299/224462"},"canonical_url":"https://search.dev.ndltd.org/etd/umn/oai:conservancy.umn.edu:11299/224462","repository":{"repo_id":"umn","name":"University of Minnesota","base_url":"https://conservancy.umn.edu/server/oai/request"},"display":{"title":"Understanding the effect of allosteric regulation of Aurora kinases on inhibitor binding","abstract":"Aurora kinase A and B regulate various signaling processes during mitosis, and their overexpression is associated with mitotic dysregulation and tumorigenesis. Many ATP-competitive inhibitors of Aurora kinases have been developed and are in various phases of clinical trials. However, the lack of correct stratification of the patient population along with a poor understanding of the structural dynamics of these kinases continue to pose a challenge in the development of Aurora inhibitors. Aurora A and B are tightly regulated by allosteric protein-protein interactions. I have tried to understand how the binding of allosteric partner-protein affects the protein dynamics, which in turn governs kinase-drug interactions.","abstract_html":"Aurora kinase A and B regulate various signaling processes during mitosis, and their overexpression is associated with mitotic dysregulation and tumorigenesis. Many ATP-competitive inhibitors of Aurora kinases have been developed and are in various phases of clinical trials. However, the lack of correct stratification of the patient population along with a poor understanding of the structural dynamics of these kinases continue to pose a challenge in the development of Aurora inhibitors. Aurora A and B are tightly regulated by allosteric protein-protein interactions. I have tried to understand how the binding of allosteric partner-protein affects the protein dynamics, which in turn governs kinase-drug interactions.","abstract_has_math":false,"creators":["Limaye, Apoorva Abhijit"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2021,"date_issued":"2021-05","date_published":"2021-05","updated_at":"2026-07-24T05:19:50Z","subjects":[],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/11299/224462","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Limaye, Apoorva Abhijit"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2021-09-24T15:57:45Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2021-09-24T15:57:45Z"]},{"key":"dc:date.issued","label":"Date","values":["2021-05"]},{"key":"dc:type","label":"Dc Type","values":["Thesis or Dissertation"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/11299/224462"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["University of Minnesota M.S. thesis. May 2021. Major: Pharmacology. Advisor: Nicholas Levinson. 1 computer file (PDF); iv, 27 pages."]},{"key":"dc:description.abstract","label":"Abstract","values":["Aurora kinase A and B regulate various signaling processes during mitosis, and their overexpression is associated with mitotic dysregulation and tumorigenesis. Many ATP-competitive inhibitors of Aurora kinases have been developed and are in various phases of clinical trials. However, the lack of correct stratification of the patient population along with a poor understanding of the structural dynamics of these kinases continue to pose a challenge in the development of Aurora inhibitors. Aurora A and B are tightly regulated by allosteric protein-protein interactions. I have tried to understand how the binding of allosteric partner-protein affects the protein dynamics, which in turn governs kinase-drug interactions."]},{"key":"dc:title","label":"Title","values":["Understanding the effect of allosteric regulation of Aurora kinases on inhibitor binding"]}]}],"canonical_facts":{"dc:creator":["Limaye, Apoorva Abhijit"],"dc:date.accessioned":["2021-09-24T15:57:45Z"],"dc:date.available":["2021-09-24T15:57:45Z"],"dc:date.issued":["2021-05"],"dc:description":["University of Minnesota M.S. thesis. May 2021. Major: Pharmacology. Advisor: Nicholas Levinson. 1 computer file (PDF); iv, 27 pages."],"dc:description.abstract":["Aurora kinase A and B regulate various signaling processes during mitosis, and their overexpression is associated with mitotic dysregulation and tumorigenesis. Many ATP-competitive inhibitors of Aurora kinases have been developed and are in various phases of clinical trials. However, the lack of correct stratification of the patient population along with a poor understanding of the structural dynamics of these kinases continue to pose a challenge in the development of Aurora inhibitors. Aurora A and B are tightly regulated by allosteric protein-protein interactions. I have tried to understand how the binding of allosteric partner-protein affects the protein dynamics, which in turn governs kinase-drug interactions."],"dc:identifier.uri":["https://hdl.handle.net/11299/224462"],"dc:language.iso":["en"],"dc:title":["Understanding the effect of allosteric regulation of Aurora kinases on inhibitor binding"],"dc:type":["Thesis or Dissertation"]},"updated_at":"2026-07-24T05:19:50Z"}