{"id":{"repo_id":"umn","oai_identifier":"oai:conservancy.umn.edu:11299/185074"},"canonical_url":"https://search.dev.ndltd.org/etd/umn/oai:conservancy.umn.edu:11299/185074","repository":{"repo_id":"umn","name":"University of Minnesota","base_url":"https://conservancy.umn.edu/server/oai/request"},"display":{"title":"Optimization of an in vitro model to study Duchenne Muscular Dystrophy","abstract":"Duchenne Muscular Dystrophy (DMD) is the most common inherited muscle disease, affecting 1 out of 5000 male live births. DMD pathology results from genetic and biochemical defects in the dystrophin-glycoprotein complex causing membrane instability, and accordingly, muscle fragility, apoptosis and abnormal calcium levels. To date, a clear understanding of the pathophysiology behind DMD remains elusive. Taking advantage of reprogramming technology to derive large numbers of DMD patient-specific myogenic cells, we aim to generate a comprehensive in vitro model system to study molecular and physiological aspects associated with different DMD mutations.","abstract_html":"Duchenne Muscular Dystrophy (DMD) is the most common inherited muscle disease, affecting 1 out of 5000 male live births. DMD pathology results from genetic and biochemical defects in the dystrophin-glycoprotein complex causing membrane instability, and accordingly, muscle fragility, apoptosis and abnormal calcium levels. To date, a clear understanding of the pathophysiology behind DMD remains elusive. Taking advantage of reprogramming technology to derive large numbers of DMD patient-specific myogenic cells, we aim to generate a comprehensive in vitro model system to study molecular and physiological aspects associated with different DMD mutations.","abstract_has_math":false,"creators":["Ortiz Cordero, Carolina"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014-12","date_published":"2014-12","updated_at":"2026-07-24T05:20:03Z","subjects":[],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11299/185074","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Ortiz Cordero, Carolina"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2017-03-14T18:53:37Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2017-03-14T18:53:37Z"]},{"key":"dc:date.issued","label":"Date","values":["2014-12"]},{"key":"dc:type","label":"Dc Type","values":["Thesis or Dissertation"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11299/185074"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["University of Minnesota M.S. thesis. December 2014. Major: Stem Cell Biology. Advisors: Susan Keirstead, Rita Perlingeiro. 1 computer file (PDF); iv, 36 pages."]},{"key":"dc:description.abstract","label":"Abstract","values":["Duchenne Muscular Dystrophy (DMD) is the most common inherited muscle disease, affecting 1 out of 5000 male live births. DMD pathology results from genetic and biochemical defects in the dystrophin-glycoprotein complex causing membrane instability, and accordingly, muscle fragility, apoptosis and abnormal calcium levels. To date, a clear understanding of the pathophysiology behind DMD remains elusive. Taking advantage of reprogramming technology to derive large numbers of DMD patient-specific myogenic cells, we aim to generate a comprehensive in vitro model system to study molecular and physiological aspects associated with different DMD mutations."]},{"key":"dc:title","label":"Title","values":["Optimization of an in vitro model to study Duchenne Muscular Dystrophy"]}]}],"canonical_facts":{"dc:creator":["Ortiz Cordero, Carolina"],"dc:date.accessioned":["2017-03-14T18:53:37Z"],"dc:date.available":["2017-03-14T18:53:37Z"],"dc:date.issued":["2014-12"],"dc:description":["University of Minnesota M.S. thesis. December 2014. Major: Stem Cell Biology. Advisors: Susan Keirstead, Rita Perlingeiro. 1 computer file (PDF); iv, 36 pages."],"dc:description.abstract":["Duchenne Muscular Dystrophy (DMD) is the most common inherited muscle disease, affecting 1 out of 5000 male live births. DMD pathology results from genetic and biochemical defects in the dystrophin-glycoprotein complex causing membrane instability, and accordingly, muscle fragility, apoptosis and abnormal calcium levels. To date, a clear understanding of the pathophysiology behind DMD remains elusive. Taking advantage of reprogramming technology to derive large numbers of DMD patient-specific myogenic cells, we aim to generate a comprehensive in vitro model system to study molecular and physiological aspects associated with different DMD mutations."],"dc:identifier.uri":["http://hdl.handle.net/11299/185074"],"dc:language.iso":["en"],"dc:title":["Optimization of an in vitro model to study Duchenne Muscular Dystrophy"],"dc:type":["Thesis or Dissertation"]},"updated_at":"2026-07-24T05:20:03Z"}