{"id":{"repo_id":"umn","oai_identifier":"oai:conservancy.umn.edu:11299/117070"},"canonical_url":"https://search.dev.ndltd.org/etd/umn/oai:conservancy.umn.edu:11299/117070","repository":{"repo_id":"umn","name":"University of Minnesota","base_url":"https://conservancy.umn.edu/server/oai/request"},"display":{"title":"Endothelium-independent dilation in children and adolescents","abstract":"Peak brachial artery dilation post-nitroglycerin (NTG) administration occurs between 3 and 5-min in adults. The purpose of this study was to identify the time to peak dilation response to sublingual NTG (0.3 mg) in youth. Endothelium-independent dilation (EID) was measured in 198 healthy (113 males, 85 females) youth (6-18 yrs) via ultrasound imaging of the brachial artery following NTG administration up to 5-min. Time to peak EID was 4-min, 28-sec, following NTG administration. There was a significant (p<0.001) difference post-NTG at the 3 vs. 4-min, 4 vs. 5-min, and 3 vs. 5-min time points. Peak EID (males: 24.8 + 0.5 vs. females: 25.3 + 0.6 %, p=0.6) was not significantly different between genders after adjusting for baseline brachial diameter. Endothelium-independent dilation was measured up to 8-min in a small sub-group of 20 youth (12 males, 8 females), resulting in a time to peak dilation of 4-min, 24-sec, and an average change in peak dilation of 23.8 + 1.2 %. No significant difference existed beyond the 4-min time point within the small sub-group. In conclusion, peak response to NTG administration occurred between 4 and 5-min. The results demonstrate the importance of measuring EID up to 5-min post-nitroglycerin administration in youth.","abstract_html":"Peak brachial artery dilation post-nitroglycerin (NTG) administration occurs between 3 and 5-min in adults. The purpose of this study was to identify the time to peak dilation response to sublingual NTG (0.3 mg) in youth. Endothelium-independent dilation (EID) was measured in 198 healthy (113 males, 85 females) youth (6-18 yrs) via ultrasound imaging of the brachial artery following NTG administration up to 5-min. Time to peak EID was 4-min, 28-sec, following NTG administration. There was a significant (p&lt;0.001) difference post-NTG at the 3 vs. 4-min, 4 vs. 5-min, and 3 vs. 5-min time points. Peak EID (males: 24.8 + 0.5 vs. females: 25.3 + 0.6 %, p=0.6) was not significantly different between genders after adjusting for baseline brachial diameter. Endothelium-independent dilation was measured up to 8-min in a small sub-group of 20 youth (12 males, 8 females), resulting in a time to peak dilation of 4-min, 24-sec, and an average change in peak dilation of 23.8 + 1.2 %. No significant difference existed beyond the 4-min time point within the small sub-group. In conclusion, peak response to NTG administration occurred between 4 and 5-min. The results demonstrate the importance of measuring EID up to 5-min post-nitroglycerin administration in youth.","abstract_has_math":false,"creators":["Marlatt, Kara Lynn"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-08","date_published":"2011-08","updated_at":"2026-07-24T05:19:50Z","subjects":["Ultrasound","Nitroglycerin","Endothelium-Independent Dilation","EID","Smooth Muscle","Vascular Function","Kinesiology"],"languages":["en_US"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://purl.umn.edu/117070","outbound_label":"Repository record","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Marlatt, Kara Lynn"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2011-10-25T21:14:22Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2011-10-25T21:14:22Z"]},{"key":"dc:date.issued","label":"Date","values":["2011-08"]},{"key":"dc:type","label":"Dc Type","values":["Thesis or Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Ultrasound","Nitroglycerin","Endothelium-Independent Dilation","EID","Smooth Muscle","Vascular Function","Kinesiology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_US"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://purl.umn.edu/117070"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["University of Minnesota M.S. thesis. August 2011. Major: Kinesiology. Advisor: Donald R. Dengel, Ph.D. 1 computer file (PDF); v, 44 pages."]},{"key":"dc:description.abstract","label":"Abstract","values":["Peak brachial artery dilation post-nitroglycerin (NTG) administration occurs between 3 and 5-min in adults. The purpose of this study was to identify the time to peak dilation response to sublingual NTG (0.3 mg) in youth. Endothelium-independent dilation (EID) was measured in 198 healthy (113 males, 85 females) youth (6-18 yrs) via ultrasound imaging of the brachial artery following NTG administration up to 5-min. Time to peak EID was 4-min, 28-sec, following NTG administration. There was a significant (p<0.001) difference post-NTG at the 3 vs. 4-min, 4 vs. 5-min, and 3 vs. 5-min time points. Peak EID (males: 24.8 + 0.5 vs. females: 25.3 + 0.6 %, p=0.6) was not significantly different between genders after adjusting for baseline brachial diameter. Endothelium-independent dilation was measured up to 8-min in a small sub-group of 20 youth (12 males, 8 females), resulting in a time to peak dilation of 4-min, 24-sec, and an average change in peak dilation of 23.8 + 1.2 %. No significant difference existed beyond the 4-min time point within the small sub-group. In conclusion, peak response to NTG administration occurred between 4 and 5-min. The results demonstrate the importance of measuring EID up to 5-min post-nitroglycerin administration in youth."]},{"key":"dc:title","label":"Title","values":["Endothelium-independent dilation in children and adolescents"]}]}],"canonical_facts":{"dc:creator":["Marlatt, Kara Lynn"],"dc:date.accessioned":["2011-10-25T21:14:22Z"],"dc:date.available":["2011-10-25T21:14:22Z"],"dc:date.issued":["2011-08"],"dc:description":["University of Minnesota M.S. thesis. August 2011. Major: Kinesiology. Advisor: Donald R. Dengel, Ph.D. 1 computer file (PDF); v, 44 pages."],"dc:description.abstract":["Peak brachial artery dilation post-nitroglycerin (NTG) administration occurs between 3 and 5-min in adults. The purpose of this study was to identify the time to peak dilation response to sublingual NTG (0.3 mg) in youth. Endothelium-independent dilation (EID) was measured in 198 healthy (113 males, 85 females) youth (6-18 yrs) via ultrasound imaging of the brachial artery following NTG administration up to 5-min. Time to peak EID was 4-min, 28-sec, following NTG administration. There was a significant (p<0.001) difference post-NTG at the 3 vs. 4-min, 4 vs. 5-min, and 3 vs. 5-min time points. Peak EID (males: 24.8 + 0.5 vs. females: 25.3 + 0.6 %, p=0.6) was not significantly different between genders after adjusting for baseline brachial diameter. Endothelium-independent dilation was measured up to 8-min in a small sub-group of 20 youth (12 males, 8 females), resulting in a time to peak dilation of 4-min, 24-sec, and an average change in peak dilation of 23.8 + 1.2 %. No significant difference existed beyond the 4-min time point within the small sub-group. In conclusion, peak response to NTG administration occurred between 4 and 5-min. The results demonstrate the importance of measuring EID up to 5-min post-nitroglycerin administration in youth."],"dc:identifier.uri":["http://purl.umn.edu/117070"],"dc:language.iso":["en_US"],"dc:subject":["Ultrasound","Nitroglycerin","Endothelium-Independent Dilation","EID","Smooth Muscle","Vascular Function","Kinesiology"],"dc:title":["Endothelium-independent dilation in children and adolescents"],"dc:type":["Thesis or Dissertation"]},"updated_at":"2026-07-24T05:19:50Z"}