{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/99521"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/99521","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Personalized absorbable gastrointestinal stents for intestinal fistulae and perforations","abstract":"Gastrointestinal (GI) tract perforations and obstructions are relatively frequent surgical emergencies, are potentially life-threatening, and can occur from several different sources. In general, treatment requires urgent surgical repair or resection and at times can lead to further complications. Currently available stents are non-absorbable, are manufactured in a narrow size range, and/or are limited to usage in locations that are accessible for endoscopic removal post-healing. The use of 3D-printed bioresorbable polymeric stents will provide patients with a stent that can prevent leakage, is tailored specifically to their geometry, will degrade with time to eliminate the need for further surgeries for stent removal post-healing, and will be usable in locations that are not endoscopically accessible. This project focused on the characterization of polycaprolactone-polydioxanone (PCL-PDO) composites for use in a bioresorbable gastrointestinal stent. Dynamic Mechanical Analysis (DMA) tests were conducted to separately analyze the effects of composition, the filament formation process, and physiological temperature on the PCL-PDO material properties. The proposed stent design was then modelled using computer-aided design, and Finite Element Analysis (FEA) was used to simulate the effects of physiologically relevant forces on stent integrity. The presence of hydrolysable ester bonds was confirmed using FTIR spectroscopy, and composite morphology was examined with scanning electron microscopy. In vitro studies were used to evaluate the biocompatibility of the polymer composite, finding that the PCL:PDO filament had no negative impact on cell viability over a period of 48 hours, and in fact was conducive to cell proliferation over a period of 3 days. PCL-PDO stents were then 3D-printed and placed in vivo in a pig model, and histological evaluation was used to determine the safety of these stents. Further analyses were conducted through stent placement in ex vivo pig intestines.","abstract_html":"Gastrointestinal (GI) tract perforations and obstructions are relatively frequent surgical emergencies, are potentially life-threatening, and can occur from several different sources. In general, treatment requires urgent surgical repair or resection and at times can lead to further complications. Currently available stents are non-absorbable, are manufactured in a narrow size range, and/or are limited to usage in locations that are accessible for endoscopic removal post-healing. The use of 3D-printed bioresorbable polymeric stents will provide patients with a stent that can prevent leakage, is tailored specifically to their geometry, will degrade with time to eliminate the need for further surgeries for stent removal post-healing, and will be usable in locations that are not endoscopically accessible. This project focused on the characterization of polycaprolactone-polydioxanone (PCL-PDO) composites for use in a bioresorbable gastrointestinal stent. Dynamic Mechanical Analysis (DMA) tests were conducted to separately analyze the effects of composition, the filament formation process, and physiological temperature on the PCL-PDO material properties. The proposed stent design was then modelled using computer-aided design, and Finite Element Analysis (FEA) was used to simulate the effects of physiologically relevant forces on stent integrity. The presence of hydrolysable ester bonds was confirmed using FTIR spectroscopy, and composite morphology was examined with scanning electron microscopy. In vitro studies were used to evaluate the biocompatibility of the polymer composite, finding that the PCL:PDO filament had no negative impact on cell viability over a period of 48 hours, and in fact was conducive to cell proliferation over a period of 3 days. PCL-PDO stents were then 3D-printed and placed in vivo in a pig model, and histological evaluation was used to determine the safety of these stents. Further analyses were conducted through stent placement in ex vivo pig intestines.","abstract_has_math":false,"creators":["Fathi, Parinaz"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Bioengineering","degree_department":null,"school":null,"contributors":["Pan, Dipanjan"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2018,"date_issued":"2018-03-13T17:35:52Z","date_published":"2018-03-13T17:35:52Z","updated_at":"2026-07-22T22:24:37Z","subjects":["Gastrointestinal tract","Leakage","Perforation","Obstruction","Stent","Polymer","Polycaprolactone","Polydioxanone","Composite"],"languages":["en"],"rights":["Copyright 2017 Parinaz Fathi"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/99521","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Pan, Dipanjan"]},{"key":"dc:creator","label":"Author","values":["Fathi, Parinaz"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2018-03-13T17:35:52Z","2020-03-14T09:15:16Z","2017-12-12","2017-12"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Bioengineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Gastrointestinal tract","Leakage","Perforation","Obstruction","Stent","Polymer","Polycaprolactone","Polydioxanone","Composite"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2017 Parinaz Fathi"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/99521"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Gastrointestinal (GI) tract perforations and obstructions are relatively frequent surgical emergencies, are potentially life-threatening, and can occur from several different sources. In general, treatment requires urgent surgical repair or resection and at times can lead to further complications. Currently available stents are non-absorbable, are manufactured in a narrow size range, and/or are limited to usage in locations that are accessible for endoscopic removal post-healing. The use of 3D-printed bioresorbable polymeric stents will provide patients with a stent that can prevent leakage, is tailored specifically to their geometry, will degrade with time to eliminate the need for further surgeries for stent removal post-healing, and will be usable in locations that are not endoscopically accessible. This project focused on the characterization of polycaprolactone-polydioxanone (PCL-PDO) composites for use in a bioresorbable gastrointestinal stent. Dynamic Mechanical Analysis (DMA) tests were conducted to separately analyze the effects of composition, the filament formation process, and physiological temperature on the PCL-PDO material properties. The proposed stent design was then modelled using computer-aided design, and Finite Element Analysis (FEA) was used to simulate the effects of physiologically relevant forces on stent integrity. The presence of hydrolysable ester bonds was confirmed using FTIR spectroscopy, and composite morphology was examined with scanning electron microscopy. In vitro studies were used to evaluate the biocompatibility of the polymer composite, finding that the PCL:PDO filament had no negative impact on cell viability over a period of 48 hours, and in fact was conducive to cell proliferation over a period of 3 days. PCL-PDO stents were then 3D-printed and placed in vivo in a pig model, and histological evaluation was used to determine the safety of these stents. Further analyses were conducted through stent placement in ex vivo pig intestines.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2019-12-01","The student, Parinaz Fathi, accepted the attached license on 2017-12-08 at 10:42.","The student, Parinaz Fathi, submitted this Thesis for approval on 2017-12-08 at 10:49.","This Thesis was approved for publication on 2017-12-12 at 09:02.","DSpace SAF Submission Ingestion Package generated from Vireo submission #11917 on 2018-03-13 at 10:37:57","Made available in DSpace on 2018-03-13T17:35:52Z (GMT). No. of bitstreams: 3 FATHI-THESIS-2017.pdf: 1901157 bytes, checksum: 828764aaf1e79b24190fd0d4a52cddd8 (MD5) Draft_120817 - Dept review.docx: 9783017 bytes, checksum: ec2fc5cebde3a443185ba7e4e3eb3273 (MD5) LICENSE.txt: 4210 bytes, checksum: 111b8b43508f67df5ce0c0280e807410 (MD5) Previous issue date: 2017-12-12","Embargo set by: Seth Robbins for item 105490 Lift date: 2020-03-13T17:36:05Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system","Limited Restriction Lifted for Item 105490 on 2020-03-14T09:15:16Z."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Personalized absorbable gastrointestinal stents for intestinal fistulae and perforations"]}]}],"canonical_facts":{"dc:contributor":["Pan, Dipanjan"],"dc:creator":["Fathi, Parinaz"],"dc:date":["2018-03-13T17:35:52Z","2020-03-14T09:15:16Z","2017-12-12","2017-12"],"dc:description":["Gastrointestinal (GI) tract perforations and obstructions are relatively frequent surgical emergencies, are potentially life-threatening, and can occur from several different sources. In general, treatment requires urgent surgical repair or resection and at times can lead to further complications. Currently available stents are non-absorbable, are manufactured in a narrow size range, and/or are limited to usage in locations that are accessible for endoscopic removal post-healing. The use of 3D-printed bioresorbable polymeric stents will provide patients with a stent that can prevent leakage, is tailored specifically to their geometry, will degrade with time to eliminate the need for further surgeries for stent removal post-healing, and will be usable in locations that are not endoscopically accessible. This project focused on the characterization of polycaprolactone-polydioxanone (PCL-PDO) composites for use in a bioresorbable gastrointestinal stent. Dynamic Mechanical Analysis (DMA) tests were conducted to separately analyze the effects of composition, the filament formation process, and physiological temperature on the PCL-PDO material properties. The proposed stent design was then modelled using computer-aided design, and Finite Element Analysis (FEA) was used to simulate the effects of physiologically relevant forces on stent integrity. The presence of hydrolysable ester bonds was confirmed using FTIR spectroscopy, and composite morphology was examined with scanning electron microscopy. In vitro studies were used to evaluate the biocompatibility of the polymer composite, finding that the PCL:PDO filament had no negative impact on cell viability over a period of 48 hours, and in fact was conducive to cell proliferation over a period of 3 days. PCL-PDO stents were then 3D-printed and placed in vivo in a pig model, and histological evaluation was used to determine the safety of these stents. Further analyses were conducted through stent placement in ex vivo pig intestines.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2019-12-01","The student, Parinaz Fathi, accepted the attached license on 2017-12-08 at 10:42.","The student, Parinaz Fathi, submitted this Thesis for approval on 2017-12-08 at 10:49.","This Thesis was approved for publication on 2017-12-12 at 09:02.","DSpace SAF Submission Ingestion Package generated from Vireo submission #11917 on 2018-03-13 at 10:37:57","Made available in DSpace on 2018-03-13T17:35:52Z (GMT). No. of bitstreams: 3 FATHI-THESIS-2017.pdf: 1901157 bytes, checksum: 828764aaf1e79b24190fd0d4a52cddd8 (MD5) Draft_120817 - Dept review.docx: 9783017 bytes, checksum: ec2fc5cebde3a443185ba7e4e3eb3273 (MD5) LICENSE.txt: 4210 bytes, checksum: 111b8b43508f67df5ce0c0280e807410 (MD5) Previous issue date: 2017-12-12","Embargo set by: Seth Robbins for item 105490 Lift date: 2020-03-13T17:36:05Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system","Limited Restriction Lifted for Item 105490 on 2020-03-14T09:15:16Z."],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/2142/99521"],"dc:language":["en"],"dc:rights":["Copyright 2017 Parinaz Fathi"],"dc:subject":["Gastrointestinal tract","Leakage","Perforation","Obstruction","Stent","Polymer","Polycaprolactone","Polydioxanone","Composite"],"dc:title":["Personalized absorbable gastrointestinal stents for intestinal fistulae and perforations"],"dc:type":["text"],"thesis:degree_discipline":["Bioengineering"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["M.S."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:24:37Z"}