{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/99496"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/99496","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Computational characterization of membrane proteins at the atomic level","abstract":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2019-12-01","abstract_html":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2019-12-01","abstract_has_math":false,"creators":["Wang, Yuhang"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Biophysics & Computnl Biology","degree_department":null,"school":null,"contributors":["Tajkhorshid, Emad","Gennis, Robert B.","Grosman, Claudio","Ferguson, Andrew L."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2018,"date_issued":"2018-03-13T17:35:37Z","date_published":"2018-03-13T17:35:37Z","updated_at":"2026-07-22T22:24:37Z","subjects":["membrane proteins, molecular dynamics, atomic level"],"languages":["en"],"rights":["Copyright 2017 Yuhang Wang"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/99496","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Tajkhorshid, Emad","Gennis, Robert B.","Grosman, Claudio","Ferguson, Andrew L."]},{"key":"dc:creator","label":"Author","values":["Wang, Yuhang"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2018-03-13T17:35:37Z","2020-03-14T09:15:16Z","2017-11-30","2017-12"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Biophysics & Computnl Biology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["membrane proteins, molecular dynamics, atomic level"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2017 Yuhang Wang"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/99496"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2019-12-01","The student, Yuhang Wang, accepted the attached license on 2017-11-29 at 18:12.","The student, Yuhang Wang, submitted this Dissertation for approval on 2017-11-29 at 18:17.","This Dissertation was approved for publication on 2017-11-30 at 11:27.","Membrane proteins are proteins either embedded or located at the peripheral of the biological membrane. The functions of membrane proteins include importing/exporting ions/small molecules into/output of the cell, cellular signaling, cell-cell interactions, etc. Molecular dynamics is a powerful computational tool that can provide an atomic level description of the dynamic interactions between molecules. During my Ph.D., I have studied several membrane proteins, including a membrane transporter (BetP), three ligand-gated ion channels (AMPA receptor, Glycine receptor, and GLIC), and a membrane signaling protein (human T-cell receptor). In these projects, I have uncovered key aspects of the functional mechanism of these proteins, such as active substrate transport, ion permeation, and antigen recognition. In addition, I have developed a new computational methodology for modeling the membrane protein-detergent micelles. I strongly believe that an atomic-level understanding of membrane proteins is essential to meet the challenges in biomedicine.","DSpace SAF Submission Ingestion Package generated from Vireo submission #11783 on 2018-03-13 at 10:34:14","Made available in DSpace on 2018-03-13T17:35:37Z (GMT). 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The functions of membrane proteins include importing/exporting ions/small molecules into/output of the cell, cellular signaling, cell-cell interactions, etc. Molecular dynamics is a powerful computational tool that can provide an atomic level description of the dynamic interactions between molecules. During my Ph.D., I have studied several membrane proteins, including a membrane transporter (BetP), three ligand-gated ion channels (AMPA receptor, Glycine receptor, and GLIC), and a membrane signaling protein (human T-cell receptor). In these projects, I have uncovered key aspects of the functional mechanism of these proteins, such as active substrate transport, ion permeation, and antigen recognition. In addition, I have developed a new computational methodology for modeling the membrane protein-detergent micelles. I strongly believe that an atomic-level understanding of membrane proteins is essential to meet the challenges in biomedicine.","DSpace SAF Submission Ingestion Package generated from Vireo submission #11783 on 2018-03-13 at 10:34:14","Made available in DSpace on 2018-03-13T17:35:37Z (GMT). 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