{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/99212"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/99212","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Self-rolled-up microtube technology for cellular outgrowth guidance and monitoring","abstract":"The evolution and optimization of self-rolled-up membranes (s-RuM) has been taking place over the past two decades at a fervent pace. This progress has culminated in a rolled-up structure that is not only insulating, but transparent and biocompatible, allowing it to be integrated into conductance, photonics, and strain-based sensor systems. These microtube-forming membranes are easily fabricated and can be integrated into a microfluidic channel (or become the channel itself) which can be easily integrated into an intravenous or catheter tube for diagnostics. In this dissertation, the advantages of silicon nitride (SiNx) based s-RuMs are investigated and outlined, showing that insulting properties allow conductance-based and capacitance-based biosensors to be easily integrated into the same channel. In addition, the metal added to this structure can act as a surface-enhanced Raman spectroscopy (SERS) sensor. Further, analyte size exclusion is possible via diameter variation and surface functionalization, adding another degree of precision. Extending this platform beyond sensing to cellular growth guidance, we find properties unique to this material system and superior to existing platforms. The SiNx s-RuM platform can be used for potential applications ranging from sensing to culturing, from disposable electronics to implants, and from brain-computer interfaces to stem-cell functionalized stints.","abstract_html":"The evolution and optimization of self-rolled-up membranes (s-RuM) has been taking place over the past two decades at a fervent pace. This progress has culminated in a rolled-up structure that is not only insulating, but transparent and biocompatible, allowing it to be integrated into conductance, photonics, and strain-based sensor systems. These microtube-forming membranes are easily fabricated and can be integrated into a microfluidic channel (or become the channel itself) which can be easily integrated into an intravenous or catheter tube for diagnostics. In this dissertation, the advantages of silicon nitride (SiNx) based s-RuMs are investigated and outlined, showing that insulting properties allow conductance-based and capacitance-based biosensors to be easily integrated into the same channel. In addition, the metal added to this structure can act as a surface-enhanced Raman spectroscopy (SERS) sensor. Further, analyte size exclusion is possible via diameter variation and surface functionalization, adding another degree of precision. Extending this platform beyond sensing to cellular growth guidance, we find properties unique to this material system and superior to existing platforms. The SiNx s-RuM platform can be used for potential applications ranging from sensing to culturing, from disposable electronics to implants, and from brain-computer interfaces to stem-cell functionalized stints.","abstract_has_math":false,"creators":["Froeter, Paul Joseph"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Electrical & Computer Engr","degree_department":null,"school":null,"contributors":["Li, Xiuling","Eden, James G.","Lyding, Joseph W.","Gillette, Martha U."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2018,"date_issued":"2018-03-13T15:25:16Z","date_published":"2018-03-13T15:25:16Z","updated_at":"2026-07-22T22:24:37Z","subjects":["Strained membrane","Microtube","Self-rolled-up membrane (s-RuM)","Neuron","Biosensor","Photonics","Microelectromechanical system (MEMS)"],"languages":["en"],"rights":["Copyright 2017 Paul Froeter"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/99212","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Li, Xiuling","Eden, James G.","Lyding, Joseph W.","Gillette, Martha U."]},{"key":"dc:creator","label":"Author","values":["Froeter, Paul Joseph"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2018-03-13T15:25:16Z","2020-03-14T09:15:19Z","2017-11-30","2017-12"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Electrical & Computer Engr"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Strained membrane","Microtube","Self-rolled-up membrane (s-RuM)","Neuron","Biosensor","Photonics","Microelectromechanical system (MEMS)"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2017 Paul Froeter"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/99212"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The evolution and optimization of self-rolled-up membranes (s-RuM) has been taking place over the past two decades at a fervent pace. This progress has culminated in a rolled-up structure that is not only insulating, but transparent and biocompatible, allowing it to be integrated into conductance, photonics, and strain-based sensor systems. These microtube-forming membranes are easily fabricated and can be integrated into a microfluidic channel (or become the channel itself) which can be easily integrated into an intravenous or catheter tube for diagnostics. In this dissertation, the advantages of silicon nitride (SiNx) based s-RuMs are investigated and outlined, showing that insulting properties allow conductance-based and capacitance-based biosensors to be easily integrated into the same channel. In addition, the metal added to this structure can act as a surface-enhanced Raman spectroscopy (SERS) sensor. Further, analyte size exclusion is possible via diameter variation and surface functionalization, adding another degree of precision. Extending this platform beyond sensing to cellular growth guidance, we find properties unique to this material system and superior to existing platforms. The SiNx s-RuM platform can be used for potential applications ranging from sensing to culturing, from disposable electronics to implants, and from brain-computer interfaces to stem-cell functionalized stints.","Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2019-12-01","The student, Paul Froeter, accepted the attached license on 2017-11-29 at 11:53.","The student, Paul Froeter, submitted this Dissertation for approval on 2017-11-29 at 12:18.","This Dissertation was approved for publication on 2017-11-30 at 13:00.","DSpace SAF Submission Ingestion Package generated from Vireo submission #11779 on 2018-03-13 at 09:56:17","Made available in DSpace on 2018-03-13T15:25:16Z (GMT). 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This progress has culminated in a rolled-up structure that is not only insulating, but transparent and biocompatible, allowing it to be integrated into conductance, photonics, and strain-based sensor systems. These microtube-forming membranes are easily fabricated and can be integrated into a microfluidic channel (or become the channel itself) which can be easily integrated into an intravenous or catheter tube for diagnostics. In this dissertation, the advantages of silicon nitride (SiNx) based s-RuMs are investigated and outlined, showing that insulting properties allow conductance-based and capacitance-based biosensors to be easily integrated into the same channel. In addition, the metal added to this structure can act as a surface-enhanced Raman spectroscopy (SERS) sensor. Further, analyte size exclusion is possible via diameter variation and surface functionalization, adding another degree of precision. Extending this platform beyond sensing to cellular growth guidance, we find properties unique to this material system and superior to existing platforms. The SiNx s-RuM platform can be used for potential applications ranging from sensing to culturing, from disposable electronics to implants, and from brain-computer interfaces to stem-cell functionalized stints.","Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2019-12-01","The student, Paul Froeter, accepted the attached license on 2017-11-29 at 11:53.","The student, Paul Froeter, submitted this Dissertation for approval on 2017-11-29 at 12:18.","This Dissertation was approved for publication on 2017-11-30 at 13:00.","DSpace SAF Submission Ingestion Package generated from Vireo submission #11779 on 2018-03-13 at 09:56:17","Made available in DSpace on 2018-03-13T15:25:16Z (GMT). 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