{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/98318"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/98318","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Absorption and fluorescence spectroscopic analysis using compact, linear variable filter based, detection platforms","abstract":"Spectroscopic analysis is an integral part of biological and chemical sensing. However, most spectroscopic equipment is relegated to laboratories. Compact and portable alternatives to conventional spectroscopic tools allow for testing outside of laboratory settings. This is achieved by making the underlying equipment affordable and easy to use while preserving reasonable accuracy and sensitivity. Due to their ubiquity, and constantly improving hardware and software, smartphones represent a favorable candidate for integration with spectroscopic technologies. This work presents the design, fabrication and characterization of compact measurement platforms capable of both absorption and fluorescence spectroscopic analysis using linear variable filters (LVF). The platform's potential for integration into next generation smartphones is demonstrated by the use of a conventional CMOS image sensor in conjunction with the LVF to create the detection element. An LVF-based benchtop detection setup is initially presented followed by its miniaturized successors: compact absorption and fluorescence detection platforms. A series of tests is discussed, most notably an enzyme-linked immunosorbent assay used to measure concentrations of human fetal fibronectin, a predictor of preterm birth, as a real-world contextualization of the absorption platform.","abstract_html":"Spectroscopic analysis is an integral part of biological and chemical sensing. However, most spectroscopic equipment is relegated to laboratories. Compact and portable alternatives to conventional spectroscopic tools allow for testing outside of laboratory settings. This is achieved by making the underlying equipment affordable and easy to use while preserving reasonable accuracy and sensitivity. Due to their ubiquity, and constantly improving hardware and software, smartphones represent a favorable candidate for integration with spectroscopic technologies. This work presents the design, fabrication and characterization of compact measurement platforms capable of both absorption and fluorescence spectroscopic analysis using linear variable filters (LVF). The platform's potential for integration into next generation smartphones is demonstrated by the use of a conventional CMOS image sensor in conjunction with the LVF to create the detection element. An LVF-based benchtop detection setup is initially presented followed by its miniaturized successors: compact absorption and fluorescence detection platforms. A series of tests is discussed, most notably an enzyme-linked immunosorbent assay used to measure concentrations of human fetal fibronectin, a predictor of preterm birth, as a real-world contextualization of the absorption platform.","abstract_has_math":false,"creators":["Almulla, Saoud A E A"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Electrical & Computer Engr","degree_department":null,"school":null,"contributors":["Dallesasse, John M.","Cunningham, Brian T."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2017,"date_issued":"2017-09-29T17:52:35Z","date_published":"2017-09-29T17:52:35Z","updated_at":"2026-07-22T22:24:35Z","subjects":["Linear variable filter","Spectroscopy","Colorimetry","Fluorometry","Complementary metal-oxide semiconductor (CMOS) sensor"],"languages":["en"],"rights":["Copyright 2017 Saoud A. 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This work presents the design, fabrication and characterization of compact measurement platforms capable of both absorption and fluorescence spectroscopic analysis using linear variable filters (LVF). The platform's potential for integration into next generation smartphones is demonstrated by the use of a conventional CMOS image sensor in conjunction with the LVF to create the detection element. An LVF-based benchtop detection setup is initially presented followed by its miniaturized successors: compact absorption and fluorescence detection platforms. A series of tests is discussed, most notably an enzyme-linked immunosorbent assay used to measure concentrations of human fetal fibronectin, a predictor of preterm birth, as a real-world contextualization of the absorption platform.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2019-08-01","The student, Saoud Almulla, accepted the attached license on 2017-07-21 at 13:03.","The student, Saoud Almulla, submitted this Thesis for approval on 2017-07-21 at 13:53.","This Thesis was approved for publication on 2017-07-21 at 14:01.","DSpace SAF Submission Ingestion Package generated from Vireo submission #11579 on 2017-09-29 at 11:20:19","Made available in DSpace on 2017-09-29T17:52:35Z (GMT). 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However, most spectroscopic equipment is relegated to laboratories. Compact and portable alternatives to conventional spectroscopic tools allow for testing outside of laboratory settings. This is achieved by making the underlying equipment affordable and easy to use while preserving reasonable accuracy and sensitivity. Due to their ubiquity, and constantly improving hardware and software, smartphones represent a favorable candidate for integration with spectroscopic technologies. This work presents the design, fabrication and characterization of compact measurement platforms capable of both absorption and fluorescence spectroscopic analysis using linear variable filters (LVF). The platform's potential for integration into next generation smartphones is demonstrated by the use of a conventional CMOS image sensor in conjunction with the LVF to create the detection element. An LVF-based benchtop detection setup is initially presented followed by its miniaturized successors: compact absorption and fluorescence detection platforms. A series of tests is discussed, most notably an enzyme-linked immunosorbent assay used to measure concentrations of human fetal fibronectin, a predictor of preterm birth, as a real-world contextualization of the absorption platform.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2019-08-01","The student, Saoud Almulla, accepted the attached license on 2017-07-21 at 13:03.","The student, Saoud Almulla, submitted this Thesis for approval on 2017-07-21 at 13:53.","This Thesis was approved for publication on 2017-07-21 at 14:01.","DSpace SAF Submission Ingestion Package generated from Vireo submission #11579 on 2017-09-29 at 11:20:19","Made available in DSpace on 2017-09-29T17:52:35Z (GMT). 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