{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/98314"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/98314","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Closed-loop bladder function control for rats using optogenetics","abstract":"Implantable devices are continuously proving to be an effective and reliable method of treatment for human patients in clinical settings. One example class of these devices is closed-loop or conditional-triggering implantable devices, which monitor physiological signals and provide necessary intervention only when necessary. Pacemakers are one of the most widely used conditional stimulating devices that continuously monitor the heart activity and electrically stimulate the heart only when abnormal conditions are detected. This thesis presents a closed-loop bladder function control system for rats. The bladder activity is monitored using a novel sensor in a less invasive manner than the traditional pressure sensors. A neuromodulation technique called optogenetics is used as the method of intervention to help control the bladder function. The battery-less implantable device is wirelessly powered via inductive resonance coupling to reduce the size of the implantable device by eliminating batteries and charging circuits. A custom-built iOS application monitors the bladder activity for abnormal behavior and triggers neuromodulation by sending a signal to the implanted device. In vivo experiments with rats demonstrate the feasibility of closed-loop implantable devices to modulate bladder function and lay the foundations for such implantable devices in clinical settings.","abstract_html":"Implantable devices are continuously proving to be an effective and reliable method of treatment for human patients in clinical settings. One example class of these devices is closed-loop or conditional-triggering implantable devices, which monitor physiological signals and provide necessary intervention only when necessary. Pacemakers are one of the most widely used conditional stimulating devices that continuously monitor the heart activity and electrically stimulate the heart only when abnormal conditions are detected. This thesis presents a closed-loop bladder function control system for rats. The bladder activity is monitored using a novel sensor in a less invasive manner than the traditional pressure sensors. A neuromodulation technique called optogenetics is used as the method of intervention to help control the bladder function. The battery-less implantable device is wirelessly powered via inductive resonance coupling to reduce the size of the implantable device by eliminating batteries and charging circuits. A custom-built iOS application monitors the bladder activity for abnormal behavior and triggers neuromodulation by sending a signal to the implanted device. In vivo experiments with rats demonstrate the feasibility of closed-loop implantable devices to modulate bladder function and lay the foundations for such implantable devices in clinical settings.","abstract_has_math":false,"creators":["Noh, Kyung Nim N"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Electrical & Computer Engr","degree_department":null,"school":null,"contributors":["Rogers, John A."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2017,"date_issued":"2017-09-29T17:52:34Z","date_published":"2017-09-29T17:52:34Z","updated_at":"2026-07-22T22:24:35Z","subjects":["Implantable","Bladder"],"languages":["en"],"rights":["Copyright 2017 Kyung Nim Noh"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/98314","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Rogers, John A."]},{"key":"dc:creator","label":"Author","values":["Noh, Kyung Nim N"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2017-09-29T17:52:34Z","2019-09-30T09:15:08Z","2017-07-21","2017-08"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Electrical & Computer Engr"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Implantable","Bladder"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2017 Kyung Nim Noh"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/98314"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Implantable devices are continuously proving to be an effective and reliable method of treatment for human patients in clinical settings. One example class of these devices is closed-loop or conditional-triggering implantable devices, which monitor physiological signals and provide necessary intervention only when necessary. Pacemakers are one of the most widely used conditional stimulating devices that continuously monitor the heart activity and electrically stimulate the heart only when abnormal conditions are detected. This thesis presents a closed-loop bladder function control system for rats. The bladder activity is monitored using a novel sensor in a less invasive manner than the traditional pressure sensors. A neuromodulation technique called optogenetics is used as the method of intervention to help control the bladder function. The battery-less implantable device is wirelessly powered via inductive resonance coupling to reduce the size of the implantable device by eliminating batteries and charging circuits. A custom-built iOS application monitors the bladder activity for abnormal behavior and triggers neuromodulation by sending a signal to the implanted device. In vivo experiments with rats demonstrate the feasibility of closed-loop implantable devices to modulate bladder function and lay the foundations for such implantable devices in clinical settings.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2019-08-01","The student, Kyung Nim Noh, accepted the attached license on 2017-07-20 at 22:22.","The student, Kyung Nim Noh, submitted this Thesis for approval on 2017-07-20 at 22:24.","This Thesis was approved for publication on 2017-07-21 at 09:09.","DSpace SAF Submission Ingestion Package generated from Vireo submission #11568 on 2017-09-29 at 11:20:14","Made available in DSpace on 2017-09-29T17:52:34Z (GMT). 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One example class of these devices is closed-loop or conditional-triggering implantable devices, which monitor physiological signals and provide necessary intervention only when necessary. Pacemakers are one of the most widely used conditional stimulating devices that continuously monitor the heart activity and electrically stimulate the heart only when abnormal conditions are detected. This thesis presents a closed-loop bladder function control system for rats. The bladder activity is monitored using a novel sensor in a less invasive manner than the traditional pressure sensors. A neuromodulation technique called optogenetics is used as the method of intervention to help control the bladder function. The battery-less implantable device is wirelessly powered via inductive resonance coupling to reduce the size of the implantable device by eliminating batteries and charging circuits. A custom-built iOS application monitors the bladder activity for abnormal behavior and triggers neuromodulation by sending a signal to the implanted device. In vivo experiments with rats demonstrate the feasibility of closed-loop implantable devices to modulate bladder function and lay the foundations for such implantable devices in clinical settings.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2019-08-01","The student, Kyung Nim Noh, accepted the attached license on 2017-07-20 at 22:22.","The student, Kyung Nim Noh, submitted this Thesis for approval on 2017-07-20 at 22:24.","This Thesis was approved for publication on 2017-07-21 at 09:09.","DSpace SAF Submission Ingestion Package generated from Vireo submission #11568 on 2017-09-29 at 11:20:14","Made available in DSpace on 2017-09-29T17:52:34Z (GMT). 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