{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/97756"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/97756","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"The effects of repeated amphetamine exposure during adolescence on behavior and prefrontal cortex function","abstract":"Cognitive impairment and altered drug sensitivity are two commonly reported behavioral outcomes of amphetamine abuse. Individuals who begin using amphetamine during adolescence may have an increased risk of developing drug-related problems because of maturational changes in mesocorticolimbic circuitry that are specific to this stage of development. The studies presented here were designed to assess long-term effects of amphetamine on cognition, dopamine receptor function, and prefrontal cortex (PFC) activity, with a focus on the consequences of drug exposure during adolescence. Chapter 1 includes a review of the literature on substance abuse and PFC dysfunction along with the specific aims of the studies described in the following chapters. Chapter 2 describes studies of drug-induced psychomotor activity and measures of working memory in rats exposed to amphetamine during adolescence or adulthood. Results suggest long-term effects of amphetamine on cognition vary according to the age of exposure. The experiments in Chapter 3 investigated the protracted effects of repeated amphetamine exposure during adolescence on psychomotor behavior and medial PFC function in young adulthood. Relative to controls, rats pre-exposed to amphetamine displayed psychomotor sensitization when challenged with amphetamine and heightened responsiveness to D1 and D2 receptor agonists. Expression of sensitization to amphetamine was attenuated in pre-exposed rats following challenges with a D1 or D2 receptor antagonist. The long-term functional impact of amphetamine on medial PFC neurons was assessed using single-unit recordings in awake behaving rats. Young adult rats were challenged with amphetamine followed by a D1 or D2 receptor antagonist. The proportion of amphetamine-responsive neurons and the pattern of spike activity was altered in animals exposed to amphetamine during adolescence relative to controls. Finally, Chapter 4 includes a general discussion on the results and implications of the experiments described in this dissertation. Taken together, the research presented here demonstrates age-dependent effects of amphetamine on cognition and highlights the long-lasting impact of amphetamine exposure on dopamine and medial PFC function.","abstract_html":"Cognitive impairment and altered drug sensitivity are two commonly reported behavioral outcomes of amphetamine abuse. Individuals who begin using amphetamine during adolescence may have an increased risk of developing drug-related problems because of maturational changes in mesocorticolimbic circuitry that are specific to this stage of development. The studies presented here were designed to assess long-term effects of amphetamine on cognition, dopamine receptor function, and prefrontal cortex (PFC) activity, with a focus on the consequences of drug exposure during adolescence. Chapter 1 includes a review of the literature on substance abuse and PFC dysfunction along with the specific aims of the studies described in the following chapters. Chapter 2 describes studies of drug-induced psychomotor activity and measures of working memory in rats exposed to amphetamine during adolescence or adulthood. Results suggest long-term effects of amphetamine on cognition vary according to the age of exposure. The experiments in Chapter 3 investigated the protracted effects of repeated amphetamine exposure during adolescence on psychomotor behavior and medial PFC function in young adulthood. Relative to controls, rats pre-exposed to amphetamine displayed psychomotor sensitization when challenged with amphetamine and heightened responsiveness to D1 and D2 receptor agonists. Expression of sensitization to amphetamine was attenuated in pre-exposed rats following challenges with a D1 or D2 receptor antagonist. The long-term functional impact of amphetamine on medial PFC neurons was assessed using single-unit recordings in awake behaving rats. Young adult rats were challenged with amphetamine followed by a D1 or D2 receptor antagonist. The proportion of amphetamine-responsive neurons and the pattern of spike activity was altered in animals exposed to amphetamine during adolescence relative to controls. Finally, Chapter 4 includes a general discussion on the results and implications of the experiments described in this dissertation. Taken together, the research presented here demonstrates age-dependent effects of amphetamine on cognition and highlights the long-lasting impact of amphetamine exposure on dopamine and medial PFC function.","abstract_has_math":false,"creators":["Sherrill, Luke K"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Psychology","degree_department":null,"school":null,"contributors":["Gulley, Joshua M.","Juraska, Janice M.","Schantz, Susan L.","Wickesberg, Robert E.","Galvez, Roberto"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2017,"date_issued":"2017-08-10T20:33:16Z","date_published":"2017-08-10T20:33:16Z","updated_at":"2026-07-22T22:24:34Z","subjects":["Amphetamine","Adolescence","Prefrontal cortex","Working memory"],"languages":["en"],"rights":["Copyright 2017 Luke Sherrill"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/97756","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Gulley, Joshua M.","Juraska, Janice M.","Schantz, Susan L.","Wickesberg, Robert E.","Galvez, Roberto"]},{"key":"dc:creator","label":"Author","values":["Sherrill, Luke K"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2017-08-10T20:33:16Z","2019-08-11T09:15:17Z","2017-04-21","2017-05"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Psychology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Amphetamine","Adolescence","Prefrontal cortex","Working memory"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2017 Luke Sherrill"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/97756"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Cognitive impairment and altered drug sensitivity are two commonly reported behavioral outcomes of amphetamine abuse. Individuals who begin using amphetamine during adolescence may have an increased risk of developing drug-related problems because of maturational changes in mesocorticolimbic circuitry that are specific to this stage of development. The studies presented here were designed to assess long-term effects of amphetamine on cognition, dopamine receptor function, and prefrontal cortex (PFC) activity, with a focus on the consequences of drug exposure during adolescence. Chapter 1 includes a review of the literature on substance abuse and PFC dysfunction along with the specific aims of the studies described in the following chapters. Chapter 2 describes studies of drug-induced psychomotor activity and measures of working memory in rats exposed to amphetamine during adolescence or adulthood. Results suggest long-term effects of amphetamine on cognition vary according to the age of exposure. The experiments in Chapter 3 investigated the protracted effects of repeated amphetamine exposure during adolescence on psychomotor behavior and medial PFC function in young adulthood. Relative to controls, rats pre-exposed to amphetamine displayed psychomotor sensitization when challenged with amphetamine and heightened responsiveness to D1 and D2 receptor agonists. Expression of sensitization to amphetamine was attenuated in pre-exposed rats following challenges with a D1 or D2 receptor antagonist. The long-term functional impact of amphetamine on medial PFC neurons was assessed using single-unit recordings in awake behaving rats. Young adult rats were challenged with amphetamine followed by a D1 or D2 receptor antagonist. The proportion of amphetamine-responsive neurons and the pattern of spike activity was altered in animals exposed to amphetamine during adolescence relative to controls. Finally, Chapter 4 includes a general discussion on the results and implications of the experiments described in this dissertation. Taken together, the research presented here demonstrates age-dependent effects of amphetamine on cognition and highlights the long-lasting impact of amphetamine exposure on dopamine and medial PFC function.","Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2019-05-01","The student, Luke Sherrill, accepted the attached license on 2017-04-20 at 15:13.","The student, Luke Sherrill, submitted this Dissertation for approval on 2017-04-20 at 15:13.","This Dissertation was approved for publication on 2017-04-21 at 09:16.","DSpace SAF Submission Ingestion Package generated from Vireo submission #10941 on 2017-08-10 at 15:06:37","Made available in DSpace on 2017-08-10T20:33:16Z (GMT). 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The experiments in Chapter 3 investigated the protracted effects of repeated amphetamine exposure during adolescence on psychomotor behavior and medial PFC function in young adulthood. Relative to controls, rats pre-exposed to amphetamine displayed psychomotor sensitization when challenged with amphetamine and heightened responsiveness to D1 and D2 receptor agonists. Expression of sensitization to amphetamine was attenuated in pre-exposed rats following challenges with a D1 or D2 receptor antagonist. The long-term functional impact of amphetamine on medial PFC neurons was assessed using single-unit recordings in awake behaving rats. Young adult rats were challenged with amphetamine followed by a D1 or D2 receptor antagonist. The proportion of amphetamine-responsive neurons and the pattern of spike activity was altered in animals exposed to amphetamine during adolescence relative to controls. Finally, Chapter 4 includes a general discussion on the results and implications of the experiments described in this dissertation. Taken together, the research presented here demonstrates age-dependent effects of amphetamine on cognition and highlights the long-lasting impact of amphetamine exposure on dopamine and medial PFC function.","Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2019-05-01","The student, Luke Sherrill, accepted the attached license on 2017-04-20 at 15:13.","The student, Luke Sherrill, submitted this Dissertation for approval on 2017-04-20 at 15:13.","This Dissertation was approved for publication on 2017-04-21 at 09:16.","DSpace SAF Submission Ingestion Package generated from Vireo submission #10941 on 2017-08-10 at 15:06:37","Made available in DSpace on 2017-08-10T20:33:16Z (GMT). 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