{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/97697"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/97697","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Differences in brain architecture during long-term recovery following mild traumatic brain injury","abstract":"Mild TBI (mTBI) is brain trauma from an external impact with a loss of consciousness less than 30 minutes. mTBI results in several biopsychosocial impairments with pronounced cognitive deficits, thought to resolve within three months of injury. Previous research suggests that these impairments are due to a temporary inability to appropriately allocate neural resources in response to cognitive demands. Our study questioned this assumption and instead hypothesized that mTBI was associated with long-term neural disruptions and compromised brain structure integrity. By extension, we investigated the likelihood that functional restitution and cognitive resolution following mTBI may be due to some form of neurofunctional reorganization. To this end, we examined abnormalities in resting state functional connectivity and structure (volume, thickness, and fractional anisotropy) in two groups of mTBI – those with 1-10 yrs. time-post injury (mTBI1-10), and those with 20-65 yrs. time post-injury (mTBI20-65), relative to age-, sex-, and education-matched controls. We observed abnormalities in brain architecture only in the mTBI1-10 group, characterized by functional hypo-activation in the right frontal pole, smaller frontal pole volume, and lesser fractional anisotropy in the genu of the corpus callosum that extended near the right frontal pole. This frontal region is laterally specialized to regulate function specific to socio-emotional processes. Collectively, neural disruptions and structural insult in mTBI may persist up to 10 years following injury but injury-related pathology may resolve with longer recovery time. Disruption to frontal-dependent function that supports socio-emotional processes may also interfere with cognitive functioning, as in the case of chronic mTBI.","abstract_html":"Mild TBI (mTBI) is brain trauma from an external impact with a loss of consciousness less than 30 minutes. mTBI results in several biopsychosocial impairments with pronounced cognitive deficits, thought to resolve within three months of injury. Previous research suggests that these impairments are due to a temporary inability to appropriately allocate neural resources in response to cognitive demands. Our study questioned this assumption and instead hypothesized that mTBI was associated with long-term neural disruptions and compromised brain structure integrity. By extension, we investigated the likelihood that functional restitution and cognitive resolution following mTBI may be due to some form of neurofunctional reorganization. To this end, we examined abnormalities in resting state functional connectivity and structure (volume, thickness, and fractional anisotropy) in two groups of mTBI – those with 1-10 yrs. time-post injury (mTBI1-10), and those with 20-65 yrs. time post-injury (mTBI20-65), relative to age-, sex-, and education-matched controls. We observed abnormalities in brain architecture only in the mTBI1-10 group, characterized by functional hypo-activation in the right frontal pole, smaller frontal pole volume, and lesser fractional anisotropy in the genu of the corpus callosum that extended near the right frontal pole. This frontal region is laterally specialized to regulate function specific to socio-emotional processes. Collectively, neural disruptions and structural insult in mTBI may persist up to 10 years following injury but injury-related pathology may resolve with longer recovery time. Disruption to frontal-dependent function that supports socio-emotional processes may also interfere with cognitive functioning, as in the case of chronic mTBI.","abstract_has_math":false,"creators":["Aishwarya, -"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.A.","degree_level":"Thesis","degree_discipline":"Psychology","degree_department":null,"school":null,"contributors":["Kramer, Arthur F.","Heller, Wendy"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2017,"date_issued":"2017-08-10T20:32:53Z","date_published":"2017-08-10T20:32:53Z","updated_at":"2026-07-22T22:24:34Z","subjects":["Mild traumatic brain injury (TBI)","Frontal pole","Long-term recovery","Resting state","Fractional anisotropy","Volume","Thickness"],"languages":["en"],"rights":["Copyright 2017 Aishwarya -"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/97697","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Kramer, Arthur F.","Heller, Wendy"]},{"key":"dc:creator","label":"Author","values":["Aishwarya, -"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2017-08-10T20:32:53Z","2019-08-11T09:15:28Z","2017-04-13","2017-05"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Psychology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.A."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Mild traumatic brain injury (TBI)","Frontal pole","Long-term recovery","Resting state","Fractional anisotropy","Volume","Thickness"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2017 Aishwarya -"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/97697"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Mild TBI (mTBI) is brain trauma from an external impact with a loss of consciousness less than 30 minutes. mTBI results in several biopsychosocial impairments with pronounced cognitive deficits, thought to resolve within three months of injury. Previous research suggests that these impairments are due to a temporary inability to appropriately allocate neural resources in response to cognitive demands. Our study questioned this assumption and instead hypothesized that mTBI was associated with long-term neural disruptions and compromised brain structure integrity. By extension, we investigated the likelihood that functional restitution and cognitive resolution following mTBI may be due to some form of neurofunctional reorganization. To this end, we examined abnormalities in resting state functional connectivity and structure (volume, thickness, and fractional anisotropy) in two groups of mTBI – those with 1-10 yrs. time-post injury (mTBI1-10), and those with 20-65 yrs. time post-injury (mTBI20-65), relative to age-, sex-, and education-matched controls. We observed abnormalities in brain architecture only in the mTBI1-10 group, characterized by functional hypo-activation in the right frontal pole, smaller frontal pole volume, and lesser fractional anisotropy in the genu of the corpus callosum that extended near the right frontal pole. This frontal region is laterally specialized to regulate function specific to socio-emotional processes. Collectively, neural disruptions and structural insult in mTBI may persist up to 10 years following injury but injury-related pathology may resolve with longer recovery time. Disruption to frontal-dependent function that supports socio-emotional processes may also interfere with cognitive functioning, as in the case of chronic mTBI.","Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2019-05-01","The student, - Aishwarya, accepted the attached license on 2017-04-13 at 10:13.","The student, - Aishwarya, submitted this Thesis for approval on 2017-04-13 at 10:54.","This Thesis was approved for publication on 2017-04-13 at 11:34.","DSpace SAF Submission Ingestion Package generated from Vireo submission #10736 on 2017-08-10 at 15:05:30","Made available in DSpace on 2017-08-10T20:32:53Z (GMT). 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Previous research suggests that these impairments are due to a temporary inability to appropriately allocate neural resources in response to cognitive demands. Our study questioned this assumption and instead hypothesized that mTBI was associated with long-term neural disruptions and compromised brain structure integrity. By extension, we investigated the likelihood that functional restitution and cognitive resolution following mTBI may be due to some form of neurofunctional reorganization. To this end, we examined abnormalities in resting state functional connectivity and structure (volume, thickness, and fractional anisotropy) in two groups of mTBI – those with 1-10 yrs. time-post injury (mTBI1-10), and those with 20-65 yrs. time post-injury (mTBI20-65), relative to age-, sex-, and education-matched controls. We observed abnormalities in brain architecture only in the mTBI1-10 group, characterized by functional hypo-activation in the right frontal pole, smaller frontal pole volume, and lesser fractional anisotropy in the genu of the corpus callosum that extended near the right frontal pole. This frontal region is laterally specialized to regulate function specific to socio-emotional processes. Collectively, neural disruptions and structural insult in mTBI may persist up to 10 years following injury but injury-related pathology may resolve with longer recovery time. Disruption to frontal-dependent function that supports socio-emotional processes may also interfere with cognitive functioning, as in the case of chronic mTBI.","Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2019-05-01","The student, - Aishwarya, accepted the attached license on 2017-04-13 at 10:13.","The student, - Aishwarya, submitted this Thesis for approval on 2017-04-13 at 10:54.","This Thesis was approved for publication on 2017-04-13 at 11:34.","DSpace SAF Submission Ingestion Package generated from Vireo submission #10736 on 2017-08-10 at 15:05:30","Made available in DSpace on 2017-08-10T20:32:53Z (GMT). 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