Fetuin-A: a novel marker for obesity and associated comorbidities
type: CreativeWork
description: Background: Obesity is a disease characterized by excess adiposity which complicates metabolism, mobility, and multiple systems in the body. Over a third of Americans have a body mass index (BMI) greater than 30 kg/m2 and therefore, are considered obese. Excess adiposity may be prevented or reduced through behavioral, pharmacological and surgical methods. Bariatric surgery results in significant and sustained loss of body weight and body fat. Many bariatric surgeries have also been termed metabolic surgeries as they result in significant improvements of metabolic abnormalities associated with obesity including dyslipidemia and insulin resistance. It is estimated that 80% of individuals with Type 2 Diabetes Mellitus (T2DM) will experience resolution after bariatric surgeries such as Roux-en-Y gastric bypass and sleeve gastrectomy (SG). Although individuals with morbid obesity have a greater risk of T2DM, 25% remain insulin-sensitive. To date, it is unclear why some develop insulin-sensitive obesity (Obsen) and others insulin-resistant obesity (Obres). A validated biomarker to distinguish these groups may aid in more targeted interventions and monitoring of at-risk populations. Fetuin-A (FetA) has shown promise as a potential marker of insulin resistance yet much about this hepatokine remains unknown. The overarching goal of this research is to understand whether FetA may be a novel marker of obesity and obesity-associated insulin resistance. Therefore, the objectives of this research were to 1) determine the role genetics play in circulating FetA and metabolic health, 2) investigate how circulating FetA responds to SG, a bariatric procedure known to markedly improve insulin sensitivity, and 3) compare FetA, adipocyte hypertrophy and weight loss trajectories between SG patients with Obsen and Obres. Methods: To determine the genetic influence of FetA, 717 college applicants to the Autonomous University of San Luis Potosi, Mexico (18-25 years old) were genotyped for si…
abstract: Background: Obesity is a disease characterized by excess adiposity which complicates metabolism, mobility, and multiple systems in the body. Over a third of Americans have a body mass index (BMI) greater than 30 kg/m2 and therefore, are considered obese. Excess adiposity may be prevented or reduced through behavioral, pharmacological and surgical methods. Bariatric surgery results in significant and sustained loss of body weight and body fat. Many bariatric surgeries have also been termed metabolic surgeries as they result in significant improvements of metabolic abnormalities associated with obesity including dyslipidemia and insulin resistance. It is estimated that 80% of individuals with Type 2 Diabetes Mellitus (T2DM) will experience resolution after bariatric surgeries such as Roux-en-Y gastric bypass and sleeve gastrectomy (SG). Although individuals with morbid obesity have a greater risk of T2DM, 25% remain insulin-sensitive. To date, it is unclear why some develop insulin-sensitive obesity (Obsen) and others insulin-resistant obesity (Obres). A validated biomarker to distinguish these groups may aid in more targeted interventions and monitoring of at-risk populations. Fetuin-A (FetA) has shown promise as a potential marker of insulin resistance yet much about this hepatokine remains unknown. The overarching goal of this research is to understand whether FetA may be a novel marker of obesity and obesity-associated insulin resistance. Therefore, the objectives of this research were to 1) determine the role genetics play in circulating FetA and metabolic health, 2) investigate how circulating FetA responds to SG, a bariatric procedure known to markedly improve insulin sensitivity, and 3) compare FetA, adipocyte hypertrophy and weight loss trajectories between SG patients with Obsen and Obres. Methods: To determine the genetic influence of FetA, 717 college applicants to the Autonomous University of San Luis Potosi, Mexico (18-25 years old) were genotyped for si…
author: Robinson, Katie Nicole
language: en
keywords: Fetuin-A, Bariatric surgery, Obesity
date published: 2017-08-10T19:52:19Z
date modified: 2026-07-22T22:24:34Z
provider: University of Illinois - Urbana-Champaign
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of Illinois at Urbana-Champaign

PropertyValue
property ID: Handle
value: http://hdl.handle.net/2142/97616