{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/97588"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/97588","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Stimulated emission from biological materials and novel optical resonators for diagnostic and imaging applications","abstract":"The first detailed optical characterization of any biological laser, providing spectral, temporal, threshold, and polarization characteristics for the flavin mononucleotide biomolecular laser, is presented here. In addition, our investigation of natural, bio-engineered, and complex biological laser systems culminates in the discovery of a phycobiliprotein laser, a 30% reduction in threshold energy for fluorescent protein lasers excited by circularly polarized light, and the development of a FRET-based laser using biotin-streptavidin bioconjugates comprising organic dye and gold nanoparticle donor/acceptor configurations. Furthermore, we introduce an optical resonator which can be fabricated from the directed assembly of a particle monolayer and is capable of producing hundreds or thousands of microlasers from a single pump beam. These optical resonators are based on an intra-cavity stabilization scheme which is well-suited for sensitive single-cell refractive index monitoring and intra-cavity in-line holography. Finally, we construct a microlens-stabilized microlaser array, based on a titanium doped sapphire crystal, which enables speckle-free pulsed laser imaging of biological specimens with nanosecond temporal resolution.","abstract_html":"The first detailed optical characterization of any biological laser, providing spectral, temporal, threshold, and polarization characteristics for the flavin mononucleotide biomolecular laser, is presented here. In addition, our investigation of natural, bio-engineered, and complex biological laser systems culminates in the discovery of a phycobiliprotein laser, a 30% reduction in threshold energy for fluorescent protein lasers excited by circularly polarized light, and the development of a FRET-based laser using biotin-streptavidin bioconjugates comprising organic dye and gold nanoparticle donor/acceptor configurations. Furthermore, we introduce an optical resonator which can be fabricated from the directed assembly of a particle monolayer and is capable of producing hundreds or thousands of microlasers from a single pump beam. These optical resonators are based on an intra-cavity stabilization scheme which is well-suited for sensitive single-cell refractive index monitoring and intra-cavity in-line holography. Finally, we construct a microlens-stabilized microlaser array, based on a titanium doped sapphire crystal, which enables speckle-free pulsed laser imaging of biological specimens with nanosecond temporal resolution.","abstract_has_math":false,"creators":["Rivera, Jose A"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Bioengineering","degree_department":null,"school":null,"contributors":["Eden, J. Gary","Cunningham, Brian T.","Insana, Michael","Carney, P. 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Furthermore, we introduce an optical resonator which can be fabricated from the directed assembly of a particle monolayer and is capable of producing hundreds or thousands of microlasers from a single pump beam. These optical resonators are based on an intra-cavity stabilization scheme which is well-suited for sensitive single-cell refractive index monitoring and intra-cavity in-line holography. Finally, we construct a microlens-stabilized microlaser array, based on a titanium doped sapphire crystal, which enables speckle-free pulsed laser imaging of biological specimens with nanosecond temporal resolution.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2019-05-01","The student, Jose Rivera, accepted the attached license on 2017-04-18 at 07:53.","The student, Jose Rivera, submitted this Dissertation for approval on 2017-04-18 at 10:58.","This Dissertation was approved for publication on 2017-04-19 at 08:59.","DSpace SAF Submission Ingestion Package generated from Vireo submission #10840 on 2017-08-10 at 14:31:01","Made available in DSpace on 2017-08-10T19:52:04Z (GMT). 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Scott"],"dc:creator":["Rivera, Jose A"],"dc:date":["2017-08-10T19:52:04Z","2019-08-11T09:15:35Z","2017-04-19","2017-05"],"dc:description":["The first detailed optical characterization of any biological laser, providing spectral, temporal, threshold, and polarization characteristics for the flavin mononucleotide biomolecular laser, is presented here. In addition, our investigation of natural, bio-engineered, and complex biological laser systems culminates in the discovery of a phycobiliprotein laser, a 30% reduction in threshold energy for fluorescent protein lasers excited by circularly polarized light, and the development of a FRET-based laser using biotin-streptavidin bioconjugates comprising organic dye and gold nanoparticle donor/acceptor configurations. Furthermore, we introduce an optical resonator which can be fabricated from the directed assembly of a particle monolayer and is capable of producing hundreds or thousands of microlasers from a single pump beam. These optical resonators are based on an intra-cavity stabilization scheme which is well-suited for sensitive single-cell refractive index monitoring and intra-cavity in-line holography. Finally, we construct a microlens-stabilized microlaser array, based on a titanium doped sapphire crystal, which enables speckle-free pulsed laser imaging of biological specimens with nanosecond temporal resolution.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2019-05-01","The student, Jose Rivera, accepted the attached license on 2017-04-18 at 07:53.","The student, Jose Rivera, submitted this Dissertation for approval on 2017-04-18 at 10:58.","This Dissertation was approved for publication on 2017-04-19 at 08:59.","DSpace SAF Submission Ingestion Package generated from Vireo submission #10840 on 2017-08-10 at 14:31:01","Made available in DSpace on 2017-08-10T19:52:04Z (GMT). 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