{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/95457"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/95457","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Development of high performance single photon emission computed tomography systems for simultaneous nuclear molecular imaging and magnetic resonance imaging","abstract":"Simultaneous nuclear molecular imaging (NMI) and magnetic resonance imaging (MRI) have great potential for pre-clinical and clinical applications, especially for cell imaging in brain cancer models. We have pursued an intensive research effort to develop high-performance single-photon emission computed tomography (SPECT) systems for simultaneous NMI/MRI. This kind of system has sub-mm and even higher resolving power that allows a matched resolution for SPECT and MRI to visualize details about cell retention and migration, and provides a significant improvement of system sensitivity, even comparable with the sensitivity of positron emission tomography (PET), enabling detection of a small number of cells. The first key step to develop a high-performance SPECT system was building the first generation MR- compatible SPECT, called MRC-SPECT-I, which was a stationary full-ring system, consisting of forty MR- compatible, energy-resolved, photon-counting, and highly-pixelated CdTe semiconductor detectors. Preliminary studies demonstrated the system ability to track as few as 400 neural stem cells in a mouse brain with a sub-500 µm resolution. Although the MRC-SPECT-I was a state-of-the-art SPECT system, to further improve SPECT performance for simultaneous NMI and MRI, an inverted compound-eye (ICE) gamma-ray camera was proposed here for SPECT imaging applications and experimentally verified through a prototype system. The MRC-SPECT-II was designed utilizing 24 ICE gamma camera modules and consisted of more than 1,500 micro-pinhole cameras. The simulation results verified that the MRC-SPECT-II system was more than ten times as sensitive as conventional SPECT systems were while retaining a sub-500 µm resolving capability. Combining the high sensitivity of the SPECT system and the high soft tissue contrast and temporal resolution of MRI, simultaneous SPECT/MRI provides an attractive platform for functional and cell imaging of a wide range of disease models, such as cancers and neurodegenerative diseases.","abstract_html":"Simultaneous nuclear molecular imaging (NMI) and magnetic resonance imaging (MRI) have great potential for pre-clinical and clinical applications, especially for cell imaging in brain cancer models. We have pursued an intensive research effort to develop high-performance single-photon emission computed tomography (SPECT) systems for simultaneous NMI/MRI. This kind of system has sub-mm and even higher resolving power that allows a matched resolution for SPECT and MRI to visualize details about cell retention and migration, and provides a significant improvement of system sensitivity, even comparable with the sensitivity of positron emission tomography (PET), enabling detection of a small number of cells. The first key step to develop a high-performance SPECT system was building the first generation MR- compatible SPECT, called MRC-SPECT-I, which was a stationary full-ring system, consisting of forty MR- compatible, energy-resolved, photon-counting, and highly-pixelated CdTe semiconductor detectors. Preliminary studies demonstrated the system ability to track as few as 400 neural stem cells in a mouse brain with a sub-500 µm resolution. Although the MRC-SPECT-I was a state-of-the-art SPECT system, to further improve SPECT performance for simultaneous NMI and MRI, an inverted compound-eye (ICE) gamma-ray camera was proposed here for SPECT imaging applications and experimentally verified through a prototype system. The MRC-SPECT-II was designed utilizing 24 ICE gamma camera modules and consisted of more than 1,500 micro-pinhole cameras. The simulation results verified that the MRC-SPECT-II system was more than ten times as sensitive as conventional SPECT systems were while retaining a sub-500 µm resolving capability. Combining the high sensitivity of the SPECT system and the high soft tissue contrast and temporal resolution of MRI, simultaneous SPECT/MRI provides an attractive platform for functional and cell imaging of a wide range of disease models, such as cancers and neurodegenerative diseases.","abstract_has_math":false,"creators":["Lai, Xiaochun"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Nuclear, Plasma, Radiolgc Engr","degree_department":null,"school":null,"contributors":["Meng, Ling-Jian","Sullivan, Clair Julia","Uddin, Rizwan","Dobrucki, Wawrzyniec Lawrence"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2017,"date_issued":"2017-03-01T16:36:41Z","date_published":"2017-03-01T16:36:41Z","updated_at":"2026-07-22T22:26:37Z","subjects":["Cadmium tellurium (CdTe)","Cadmium zinc tellurium (CZT)","Energy resolved photon counting detector","Single photon emission computed tomography (SPECT)","MR compatible SPECT","Compound eye gamma camera","SPECT/MRI","Nuclear molecular imaging","Cell imaging"],"languages":["en"],"rights":["Copyright 2016 Xiaochun Lai"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/95457","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Meng, Ling-Jian","Sullivan, Clair Julia","Uddin, Rizwan","Dobrucki, Wawrzyniec Lawrence"]},{"key":"dc:creator","label":"Author","values":["Lai, Xiaochun"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2017-03-01T16:36:41Z","2019-03-02T10:15:27Z","2016-09-27","2016-12"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Nuclear, Plasma, Radiolgc Engr"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Cadmium tellurium (CdTe)","Cadmium zinc tellurium (CZT)","Energy resolved photon counting detector","Single photon emission computed tomography (SPECT)","MR compatible SPECT","Compound eye gamma camera","SPECT/MRI","Nuclear molecular imaging","Cell imaging"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2016 Xiaochun Lai"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/95457"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Simultaneous nuclear molecular imaging (NMI) and magnetic resonance imaging (MRI) have great potential for pre-clinical and clinical applications, especially for cell imaging in brain cancer models. We have pursued an intensive research effort to develop high-performance single-photon emission computed tomography (SPECT) systems for simultaneous NMI/MRI. This kind of system has sub-mm and even higher resolving power that allows a matched resolution for SPECT and MRI to visualize details about cell retention and migration, and provides a significant improvement of system sensitivity, even comparable with the sensitivity of positron emission tomography (PET), enabling detection of a small number of cells. The first key step to develop a high-performance SPECT system was building the first generation MR- compatible SPECT, called MRC-SPECT-I, which was a stationary full-ring system, consisting of forty MR- compatible, energy-resolved, photon-counting, and highly-pixelated CdTe semiconductor detectors. Preliminary studies demonstrated the system ability to track as few as 400 neural stem cells in a mouse brain with a sub-500 µm resolution. Although the MRC-SPECT-I was a state-of-the-art SPECT system, to further improve SPECT performance for simultaneous NMI and MRI, an inverted compound-eye (ICE) gamma-ray camera was proposed here for SPECT imaging applications and experimentally verified through a prototype system. The MRC-SPECT-II was designed utilizing 24 ICE gamma camera modules and consisted of more than 1,500 micro-pinhole cameras. The simulation results verified that the MRC-SPECT-II system was more than ten times as sensitive as conventional SPECT systems were while retaining a sub-500 µm resolving capability. Combining the high sensitivity of the SPECT system and the high soft tissue contrast and temporal resolution of MRI, simultaneous SPECT/MRI provides an attractive platform for functional and cell imaging of a wide range of disease models, such as cancers and neurodegenerative diseases.","Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2018-12-01","The student, Xiaochun Lai, accepted the attached license on 2016-09-23 at 17:28.","The student, Xiaochun Lai, submitted this Dissertation for approval on 2016-09-23 at 17:29.","This Dissertation was approved for publication on 2016-09-27 at 11:15.","DSpace SAF Submission Ingestion Package generated from Vireo submission #10169 on 2017-02-28 at 14:36:00","Made available in DSpace on 2017-03-01T16:36:41Z (GMT). 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We have pursued an intensive research effort to develop high-performance single-photon emission computed tomography (SPECT) systems for simultaneous NMI/MRI. This kind of system has sub-mm and even higher resolving power that allows a matched resolution for SPECT and MRI to visualize details about cell retention and migration, and provides a significant improvement of system sensitivity, even comparable with the sensitivity of positron emission tomography (PET), enabling detection of a small number of cells. The first key step to develop a high-performance SPECT system was building the first generation MR- compatible SPECT, called MRC-SPECT-I, which was a stationary full-ring system, consisting of forty MR- compatible, energy-resolved, photon-counting, and highly-pixelated CdTe semiconductor detectors. Preliminary studies demonstrated the system ability to track as few as 400 neural stem cells in a mouse brain with a sub-500 µm resolution. Although the MRC-SPECT-I was a state-of-the-art SPECT system, to further improve SPECT performance for simultaneous NMI and MRI, an inverted compound-eye (ICE) gamma-ray camera was proposed here for SPECT imaging applications and experimentally verified through a prototype system. The MRC-SPECT-II was designed utilizing 24 ICE gamma camera modules and consisted of more than 1,500 micro-pinhole cameras. The simulation results verified that the MRC-SPECT-II system was more than ten times as sensitive as conventional SPECT systems were while retaining a sub-500 µm resolving capability. Combining the high sensitivity of the SPECT system and the high soft tissue contrast and temporal resolution of MRI, simultaneous SPECT/MRI provides an attractive platform for functional and cell imaging of a wide range of disease models, such as cancers and neurodegenerative diseases.","Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2018-12-01","The student, Xiaochun Lai, accepted the attached license on 2016-09-23 at 17:28.","The student, Xiaochun Lai, submitted this Dissertation for approval on 2016-09-23 at 17:29.","This Dissertation was approved for publication on 2016-09-27 at 11:15.","DSpace SAF Submission Ingestion Package generated from Vireo submission #10169 on 2017-02-28 at 14:36:00","Made available in DSpace on 2017-03-01T16:36:41Z (GMT). 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