{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/95384"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/95384","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Macro- and micro-structural features direct bone regeneration in patterned biphasic calcium phosphate scaffolds","abstract":"The increasing demand for bone repair solutions for the treatment of large and load-bearing bone defects calls for the development of efficacious bone scaffolds. The design of such scaffolds involves a range of length scales from the centimeter down to the micron-scale. Biphasic calcium phosphate (BCP) scaffolds with both macropores and micropores (MP) show enhanced bone healing compared to those with macropores and no micropores (NMP), but the role of micropores is unclear. In this work, we assess the influence of scaffold macro- (> 300 μm) and microporosity (< 50 μm) on bone regeneration in BCP scaffolds implanted in pig mandibles. We evaluate capillarity induced by micropores as a mechanism that affects bone growth in vivo. We also assess the influence on bone volume, bone distribution and trabecular thickness of scaffold macro- and microporosity, as well as the ability of scaffold structure to direct bone growth in scaffolds combining domains with different architectures at the millimeter scale. Our results show that microporosity enhances bone regeneration through microporeinduced capillarity by improving the homogeneity of bone distribution in BCP scaffolds, suggesting that the explicit design and use of capillarity in bone scaffolds may lead to more effective treatments of large and complex bone defects. We also show that microporosity enhances bone volume fraction and bone distribution, regardless of macropore size. Microporosity increases trabecular thickness throughout the scaffold, while macropore size affects it only at the scaffold periphery. Finally, our results suggest that combining different architectures into one scaffold at the millimeter scale conserves the properties of each domain. Hence, bone growth and morphology can be tailored by controlling scaffold architecture from the millimeter down to the micron level. This holds promise for the customization of scaffold designs for more effective treatment of large and load-bearing bone defects.","abstract_html":"The increasing demand for bone repair solutions for the treatment of large and load-bearing bone defects calls for the development of efficacious bone scaffolds. The design of such scaffolds involves a range of length scales from the centimeter down to the micron-scale. Biphasic calcium phosphate (BCP) scaffolds with both macropores and micropores (MP) show enhanced bone healing compared to those with macropores and no micropores (NMP), but the role of micropores is unclear. In this work, we assess the influence of scaffold macro- (&gt; 300 μm) and microporosity (&lt; 50 μm) on bone regeneration in BCP scaffolds implanted in pig mandibles. We evaluate capillarity induced by micropores as a mechanism that affects bone growth in vivo. We also assess the influence on bone volume, bone distribution and trabecular thickness of scaffold macro- and microporosity, as well as the ability of scaffold structure to direct bone growth in scaffolds combining domains with different architectures at the millimeter scale. Our results show that microporosity enhances bone regeneration through microporeinduced capillarity by improving the homogeneity of bone distribution in BCP scaffolds, suggesting that the explicit design and use of capillarity in bone scaffolds may lead to more effective treatments of large and complex bone defects. We also show that microporosity enhances bone volume fraction and bone distribution, regardless of macropore size. Microporosity increases trabecular thickness throughout the scaffold, while macropore size affects it only at the scaffold periphery. Finally, our results suggest that combining different architectures into one scaffold at the millimeter scale conserves the properties of each domain. Hence, bone growth and morphology can be tailored by controlling scaffold architecture from the millimeter down to the micron level. This holds promise for the customization of scaffold designs for more effective treatment of large and load-bearing bone defects.","abstract_has_math":false,"creators":["Rustom, Laurence"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Bioengineering","degree_department":null,"school":null,"contributors":["Wagoner Johnson, Amy J.","Sutton, Bradley P.","Harley, Brendan AC","Underhill, Gregory H."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2017,"date_issued":"2017-03-01T15:49:23Z","date_published":"2017-03-01T15:49:23Z","updated_at":"2026-07-22T22:26:37Z","subjects":["osteointegration","large defects","tissue engineering","micro-CT","histology","bone scaffold","calcium phosphate"],"languages":["en"],"rights":["Copyright 2016 Laurence Rustom"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/95384","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Wagoner Johnson, Amy J.","Sutton, Bradley P.","Harley, Brendan AC","Underhill, Gregory H."]},{"key":"dc:creator","label":"Author","values":["Rustom, Laurence"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2017-03-01T15:49:23Z","2016-12-02","2016-12"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Bioengineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["osteointegration","large defects","tissue engineering","micro-CT","histology","bone scaffold","calcium phosphate"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2016 Laurence Rustom"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/95384"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The increasing demand for bone repair solutions for the treatment of large and load-bearing bone defects calls for the development of efficacious bone scaffolds. The design of such scaffolds involves a range of length scales from the centimeter down to the micron-scale. Biphasic calcium phosphate (BCP) scaffolds with both macropores and micropores (MP) show enhanced bone healing compared to those with macropores and no micropores (NMP), but the role of micropores is unclear. In this work, we assess the influence of scaffold macro- (> 300 μm) and microporosity (< 50 μm) on bone regeneration in BCP scaffolds implanted in pig mandibles. We evaluate capillarity induced by micropores as a mechanism that affects bone growth in vivo. We also assess the influence on bone volume, bone distribution and trabecular thickness of scaffold macro- and microporosity, as well as the ability of scaffold structure to direct bone growth in scaffolds combining domains with different architectures at the millimeter scale. Our results show that microporosity enhances bone regeneration through microporeinduced capillarity by improving the homogeneity of bone distribution in BCP scaffolds, suggesting that the explicit design and use of capillarity in bone scaffolds may lead to more effective treatments of large and complex bone defects. We also show that microporosity enhances bone volume fraction and bone distribution, regardless of macropore size. Microporosity increases trabecular thickness throughout the scaffold, while macropore size affects it only at the scaffold periphery. Finally, our results suggest that combining different architectures into one scaffold at the millimeter scale conserves the properties of each domain. Hence, bone growth and morphology can be tailored by controlling scaffold architecture from the millimeter down to the micron level. This holds promise for the customization of scaffold designs for more effective treatment of large and load-bearing bone defects.","Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2017-02-28 without embargo terms","The student, Laurence Rustom, accepted the attached license on 2016-12-01 at 14:50.","The student, Laurence Rustom, submitted this Dissertation for approval on 2016-12-01 at 15:12.","This Dissertation was approved for publication on 2016-12-02 at 16:17.","DSpace SAF Submission Ingestion Package generated from Vireo submission #10402 on 2017-02-28 at 14:55:06","Made available in DSpace on 2017-03-01T15:49:23Z (GMT). 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Biphasic calcium phosphate (BCP) scaffolds with both macropores and micropores (MP) show enhanced bone healing compared to those with macropores and no micropores (NMP), but the role of micropores is unclear. In this work, we assess the influence of scaffold macro- (> 300 μm) and microporosity (< 50 μm) on bone regeneration in BCP scaffolds implanted in pig mandibles. We evaluate capillarity induced by micropores as a mechanism that affects bone growth in vivo. We also assess the influence on bone volume, bone distribution and trabecular thickness of scaffold macro- and microporosity, as well as the ability of scaffold structure to direct bone growth in scaffolds combining domains with different architectures at the millimeter scale. Our results show that microporosity enhances bone regeneration through microporeinduced capillarity by improving the homogeneity of bone distribution in BCP scaffolds, suggesting that the explicit design and use of capillarity in bone scaffolds may lead to more effective treatments of large and complex bone defects. We also show that microporosity enhances bone volume fraction and bone distribution, regardless of macropore size. Microporosity increases trabecular thickness throughout the scaffold, while macropore size affects it only at the scaffold periphery. Finally, our results suggest that combining different architectures into one scaffold at the millimeter scale conserves the properties of each domain. Hence, bone growth and morphology can be tailored by controlling scaffold architecture from the millimeter down to the micron level. This holds promise for the customization of scaffold designs for more effective treatment of large and load-bearing bone defects.","Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2017-02-28 without embargo terms","The student, Laurence Rustom, accepted the attached license on 2016-12-01 at 14:50.","The student, Laurence Rustom, submitted this Dissertation for approval on 2016-12-01 at 15:12.","This Dissertation was approved for publication on 2016-12-02 at 16:17.","DSpace SAF Submission Ingestion Package generated from Vireo submission #10402 on 2017-02-28 at 14:55:06","Made available in DSpace on 2017-03-01T15:49:23Z (GMT). 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