{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/93017"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/93017","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Function follows form: novel structured encapsulation materials via microfluidics","abstract":"Materials are composed of more than just their atomical makeup. Everywhere we look in nature and in man-made materials, there is an essence of structure that imparts mechanical, physical, and chemical characteristics; a reason behind why bones are porous, ceramics are heat-resistant, and composites are resilient. Materials science students know this better than others as part of our core curriculum, yet there are many avenues and applications for which these principles have yet to be applied. My research, though a collection of diverse projects, has focused on how we can specifically engineer encapsulation materials with the desired properties simply by changing the hierarchy of said material, and how to better understand the sensitive interplay between structural parameters. Beginning in Chapter 1, I focus on how from a single polymeric material core-shell microcapsule, we demonstrated the controllable, reversible, and pH-triggerable release of actives by tuning the pore sizes of the microcapsules, leading to mechanical measurements of individual microcapsules through the use of nanoindentation in Chapter 2. This chapter also documents my investigations into structure-mechanical property relationships toward a universal theory of capsule yield stress. Chapter 3 focuses on the development of a high-throughput tissue model system and investigates the effects of cellular encapsulation and geometric effects of vasculature on tumorous tissue behavior. Similar in the way that cells are directly influenced by the stiffness of their substrate, we found that tumors are also responsive to the shape of the nearby vasculature and other diffusional constrains and conditions.","abstract_html":"Materials are composed of more than just their atomical makeup. Everywhere we look in nature and in man-made materials, there is an essence of structure that imparts mechanical, physical, and chemical characteristics; a reason behind why bones are porous, ceramics are heat-resistant, and composites are resilient. Materials science students know this better than others as part of our core curriculum, yet there are many avenues and applications for which these principles have yet to be applied. My research, though a collection of diverse projects, has focused on how we can specifically engineer encapsulation materials with the desired properties simply by changing the hierarchy of said material, and how to better understand the sensitive interplay between structural parameters. Beginning in Chapter 1, I focus on how from a single polymeric material core-shell microcapsule, we demonstrated the controllable, reversible, and pH-triggerable release of actives by tuning the pore sizes of the microcapsules, leading to mechanical measurements of individual microcapsules through the use of nanoindentation in Chapter 2. This chapter also documents my investigations into structure-mechanical property relationships toward a universal theory of capsule yield stress. Chapter 3 focuses on the development of a high-throughput tissue model system and investigates the effects of cellular encapsulation and geometric effects of vasculature on tumorous tissue behavior. Similar in the way that cells are directly influenced by the stiffness of their substrate, we found that tumors are also responsive to the shape of the nearby vasculature and other diffusional constrains and conditions.","abstract_has_math":false,"creators":["Grolman, Joshua Micah"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Materials Science & Engr","degree_department":null,"school":null,"contributors":["Moore, Jeffrey S.","Braun, Paul V.","Kilian, Kristopher","Chen, Qian"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2016,"date_issued":"2016-11-10T18:39:12Z","date_published":"2016-11-10T18:39:12Z","updated_at":"2026-07-22T22:26:35Z","subjects":["Microfluidics","Encapsulation","Tumor model"],"languages":["en"],"rights":["© 2016 Joshua Micah Grolman"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/93017","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Moore, Jeffrey S.","Braun, Paul V.","Kilian, Kristopher","Chen, Qian"]},{"key":"dc:creator","label":"Author","values":["Grolman, Joshua Micah"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2016-11-10T18:39:12Z","2018-11-11T10:15:36Z","2016-06-24","2016-08"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Materials Science & Engr"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Microfluidics","Encapsulation","Tumor model"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["© 2016 Joshua Micah Grolman"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/93017"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Materials are composed of more than just their atomical makeup. Everywhere we look in nature and in man-made materials, there is an essence of structure that imparts mechanical, physical, and chemical characteristics; a reason behind why bones are porous, ceramics are heat-resistant, and composites are resilient. Materials science students know this better than others as part of our core curriculum, yet there are many avenues and applications for which these principles have yet to be applied. My research, though a collection of diverse projects, has focused on how we can specifically engineer encapsulation materials with the desired properties simply by changing the hierarchy of said material, and how to better understand the sensitive interplay between structural parameters. Beginning in Chapter 1, I focus on how from a single polymeric material core-shell microcapsule, we demonstrated the controllable, reversible, and pH-triggerable release of actives by tuning the pore sizes of the microcapsules, leading to mechanical measurements of individual microcapsules through the use of nanoindentation in Chapter 2. This chapter also documents my investigations into structure-mechanical property relationships toward a universal theory of capsule yield stress. Chapter 3 focuses on the development of a high-throughput tissue model system and investigates the effects of cellular encapsulation and geometric effects of vasculature on tumorous tissue behavior. Similar in the way that cells are directly influenced by the stiffness of their substrate, we found that tumors are also responsive to the shape of the nearby vasculature and other diffusional constrains and conditions.","Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2018-08-01","The student, Joshua Grolman, accepted the attached license on 2016-06-23 at 16:33.","The student, Joshua Grolman, submitted this Dissertation for approval on 2016-06-23 at 16:38.","This Dissertation was approved for publication on 2016-06-24 at 12:22.","DSpace SAF Submission Ingestion Package generated from Vireo submission #9698 on 2016-11-10 at 12:24:40","Made available in DSpace on 2016-11-10T18:39:12Z (GMT). No. of bitstreams: 2 GROLMAN-DISSERTATION-2016.pdf: 5429264 bytes, checksum: 3b5f220b3c31e5e2aaa4edf422d3d72f (MD5) LICENSE.txt: 4211 bytes, checksum: 761473d7d49012556bc7f23ec0c3b02b (MD5) Previous issue date: 2016-06-24","Embargo set by: Seth Robbins for item 95439 Lift date: 2018-11-10T18:39:22Z Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD system","Embargo set by: Seth Robbins for item 95439 Lift date: 2018-11-10T18:43:22Z Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD system","U of I Only Restriction Lifted for Item 95439 on 2018-11-11T10:15:36Z."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Function follows form: novel structured encapsulation materials via microfluidics"]}]}],"canonical_facts":{"dc:contributor":["Moore, Jeffrey S.","Braun, Paul V.","Kilian, Kristopher","Chen, Qian"],"dc:creator":["Grolman, Joshua Micah"],"dc:date":["2016-11-10T18:39:12Z","2018-11-11T10:15:36Z","2016-06-24","2016-08"],"dc:description":["Materials are composed of more than just their atomical makeup. Everywhere we look in nature and in man-made materials, there is an essence of structure that imparts mechanical, physical, and chemical characteristics; a reason behind why bones are porous, ceramics are heat-resistant, and composites are resilient. Materials science students know this better than others as part of our core curriculum, yet there are many avenues and applications for which these principles have yet to be applied. My research, though a collection of diverse projects, has focused on how we can specifically engineer encapsulation materials with the desired properties simply by changing the hierarchy of said material, and how to better understand the sensitive interplay between structural parameters. Beginning in Chapter 1, I focus on how from a single polymeric material core-shell microcapsule, we demonstrated the controllable, reversible, and pH-triggerable release of actives by tuning the pore sizes of the microcapsules, leading to mechanical measurements of individual microcapsules through the use of nanoindentation in Chapter 2. This chapter also documents my investigations into structure-mechanical property relationships toward a universal theory of capsule yield stress. Chapter 3 focuses on the development of a high-throughput tissue model system and investigates the effects of cellular encapsulation and geometric effects of vasculature on tumorous tissue behavior. Similar in the way that cells are directly influenced by the stiffness of their substrate, we found that tumors are also responsive to the shape of the nearby vasculature and other diffusional constrains and conditions.","Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2018-08-01","The student, Joshua Grolman, accepted the attached license on 2016-06-23 at 16:33.","The student, Joshua Grolman, submitted this Dissertation for approval on 2016-06-23 at 16:38.","This Dissertation was approved for publication on 2016-06-24 at 12:22.","DSpace SAF Submission Ingestion Package generated from Vireo submission #9698 on 2016-11-10 at 12:24:40","Made available in DSpace on 2016-11-10T18:39:12Z (GMT). No. of bitstreams: 2 GROLMAN-DISSERTATION-2016.pdf: 5429264 bytes, checksum: 3b5f220b3c31e5e2aaa4edf422d3d72f (MD5) LICENSE.txt: 4211 bytes, checksum: 761473d7d49012556bc7f23ec0c3b02b (MD5) Previous issue date: 2016-06-24","Embargo set by: Seth Robbins for item 95439 Lift date: 2018-11-10T18:39:22Z Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD system","Embargo set by: Seth Robbins for item 95439 Lift date: 2018-11-10T18:43:22Z Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD system","U of I Only Restriction Lifted for Item 95439 on 2018-11-11T10:15:36Z."],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/2142/93017"],"dc:language":["en"],"dc:rights":["© 2016 Joshua Micah Grolman"],"dc:subject":["Microfluidics","Encapsulation","Tumor model"],"dc:title":["Function follows form: novel structured encapsulation materials via microfluidics"],"dc:type":["text"],"thesis:degree_discipline":["Materials Science & Engr"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:26:35Z"}