{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/92767"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/92767","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Set shifting ability of rats perinatally exposed to bisphenol A and a high fat diet","abstract":"Bisphenol-A (BPA) is an endocrine disruptor found ubiquitously in the environment. It has been shown to have a wide variety of effects on behavior and cognition as well as causing inflammation in the brain. Additionally, the traditional American diet is high fat, which also contributes to both physiological, behavioral and inflammation problems. Together, these two factors could exacerbate one another in the brain, which could lead to some cognitive impairment. In order to test this hypothesis, pregnant female rats consumed 0, 40, or 400 μg/kg of BPA daily and either a control (CON; 18.5% kcal) or a high-fat diet (HF, 45% kcal) during gestation. The corresponding dose of BPA was pipetted into male and female pups' mouths from postnatal days (PND) 1-10 while the dams remained on their respective diets. After PND 10, dams were placed on separate chow diet which was maintained for the remainder of the offspring's life. As adults (>PND 90), the perinatally exposed rats were tested on an extra-dimensional set-shifting task. A rotating plus maze with black/white and rough/smooth arms was used. Final analysis indicates that there were no significant treatment differences for the number of trials needed to reach criterion during the initial discrimination. Additionally, there were no significant effects of treatment for accuracy or perseveration during the extra-dimensional shift. There were significant 3-way interactions, one between dose and diet, and the other between dose and diet and block. However, post hoc analyses revealed no significant differences from control doses, only between doses of BPA. Finally, there was a significant sex difference between males and females in number of random errors made with females having more errors than males.","abstract_html":"Bisphenol-A (BPA) is an endocrine disruptor found ubiquitously in the environment. It has been shown to have a wide variety of effects on behavior and cognition as well as causing inflammation in the brain. Additionally, the traditional American diet is high fat, which also contributes to both physiological, behavioral and inflammation problems. Together, these two factors could exacerbate one another in the brain, which could lead to some cognitive impairment. In order to test this hypothesis, pregnant female rats consumed 0, 40, or 400 μg/kg of BPA daily and either a control (CON; 18.5% kcal) or a high-fat diet (HF, 45% kcal) during gestation. The corresponding dose of BPA was pipetted into male and female pups' mouths from postnatal days (PND) 1-10 while the dams remained on their respective diets. After PND 10, dams were placed on separate chow diet which was maintained for the remainder of the offspring's life. As adults (>PND 90), the perinatally exposed rats were tested on an extra-dimensional set-shifting task. A rotating plus maze with black/white and rough/smooth arms was used. Final analysis indicates that there were no significant treatment differences for the number of trials needed to reach criterion during the initial discrimination. Additionally, there were no significant effects of treatment for accuracy or perseveration during the extra-dimensional shift. There were significant 3-way interactions, one between dose and diet, and the other between dose and diet and block. However, post hoc analyses revealed no significant differences from control doses, only between doses of BPA. Finally, there was a significant sex difference between males and females in number of random errors made with females having more errors than males.","abstract_has_math":false,"creators":["Cuenod, Bethany Alberta"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.A.","degree_level":"Thesis","degree_discipline":"Psychology","degree_department":null,"school":null,"contributors":["Juraska, Janice","Rhodes, Justin"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2016,"date_issued":"2016-11-10T17:50:12Z","date_published":"2016-11-10T17:50:12Z","updated_at":"2026-07-22T22:26:35Z","subjects":["perinatal BPA","high fat diet","cognitive flexibility"],"languages":["en"],"rights":["Copyright 2016 Bethany Cuenod"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/92767","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Juraska, Janice","Rhodes, Justin"]},{"key":"dc:creator","label":"Author","values":["Cuenod, Bethany Alberta"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2016-11-10T17:50:12Z","2016-07-07","2016-08"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Psychology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.A."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["perinatal BPA","high fat diet","cognitive flexibility"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2016 Bethany Cuenod"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/92767"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Bisphenol-A (BPA) is an endocrine disruptor found ubiquitously in the environment. It has been shown to have a wide variety of effects on behavior and cognition as well as causing inflammation in the brain. Additionally, the traditional American diet is high fat, which also contributes to both physiological, behavioral and inflammation problems. Together, these two factors could exacerbate one another in the brain, which could lead to some cognitive impairment. In order to test this hypothesis, pregnant female rats consumed 0, 40, or 400 μg/kg of BPA daily and either a control (CON; 18.5% kcal) or a high-fat diet (HF, 45% kcal) during gestation. The corresponding dose of BPA was pipetted into male and female pups' mouths from postnatal days (PND) 1-10 while the dams remained on their respective diets. After PND 10, dams were placed on separate chow diet which was maintained for the remainder of the offspring's life. As adults (>PND 90), the perinatally exposed rats were tested on an extra-dimensional set-shifting task. A rotating plus maze with black/white and rough/smooth arms was used. Final analysis indicates that there were no significant treatment differences for the number of trials needed to reach criterion during the initial discrimination. Additionally, there were no significant effects of treatment for accuracy or perseveration during the extra-dimensional shift. There were significant 3-way interactions, one between dose and diet, and the other between dose and diet and block. However, post hoc analyses revealed no significant differences from control doses, only between doses of BPA. Finally, there was a significant sex difference between males and females in number of random errors made with females having more errors than males.","Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2016-11-09 without embargo terms","The student, Bethany Cuenod, accepted the attached license on 2016-07-06 at 16:06.","The student, Bethany Cuenod, submitted this Thesis for approval on 2016-07-06 at 16:17.","This Thesis was approved for publication on 2016-07-07 at 15:09.","DSpace SAF Submission Ingestion Package generated from Vireo submission #9789 on 2016-11-09 at 10:22:58","Made available in DSpace on 2016-11-10T17:50:12Z (GMT). No. of bitstreams: 2 CUENOD-THESIS-2016.pdf: 866099 bytes, checksum: 4c8ffd698d291c9b2f226e101b134e28 (MD5) LICENSE.txt: 4211 bytes, checksum: d0b3f06baac0b50875cdf85256116c1b (MD5) Previous issue date: 2016-07-07"]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Set shifting ability of rats perinatally exposed to bisphenol A and a high fat diet"]}]}],"canonical_facts":{"dc:contributor":["Juraska, Janice","Rhodes, Justin"],"dc:creator":["Cuenod, Bethany Alberta"],"dc:date":["2016-11-10T17:50:12Z","2016-07-07","2016-08"],"dc:description":["Bisphenol-A (BPA) is an endocrine disruptor found ubiquitously in the environment. It has been shown to have a wide variety of effects on behavior and cognition as well as causing inflammation in the brain. Additionally, the traditional American diet is high fat, which also contributes to both physiological, behavioral and inflammation problems. Together, these two factors could exacerbate one another in the brain, which could lead to some cognitive impairment. In order to test this hypothesis, pregnant female rats consumed 0, 40, or 400 μg/kg of BPA daily and either a control (CON; 18.5% kcal) or a high-fat diet (HF, 45% kcal) during gestation. The corresponding dose of BPA was pipetted into male and female pups' mouths from postnatal days (PND) 1-10 while the dams remained on their respective diets. After PND 10, dams were placed on separate chow diet which was maintained for the remainder of the offspring's life. As adults (>PND 90), the perinatally exposed rats were tested on an extra-dimensional set-shifting task. A rotating plus maze with black/white and rough/smooth arms was used. Final analysis indicates that there were no significant treatment differences for the number of trials needed to reach criterion during the initial discrimination. Additionally, there were no significant effects of treatment for accuracy or perseveration during the extra-dimensional shift. There were significant 3-way interactions, one between dose and diet, and the other between dose and diet and block. However, post hoc analyses revealed no significant differences from control doses, only between doses of BPA. Finally, there was a significant sex difference between males and females in number of random errors made with females having more errors than males.","Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2016-11-09 without embargo terms","The student, Bethany Cuenod, accepted the attached license on 2016-07-06 at 16:06.","The student, Bethany Cuenod, submitted this Thesis for approval on 2016-07-06 at 16:17.","This Thesis was approved for publication on 2016-07-07 at 15:09.","DSpace SAF Submission Ingestion Package generated from Vireo submission #9789 on 2016-11-09 at 10:22:58","Made available in DSpace on 2016-11-10T17:50:12Z (GMT). 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