{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/92690"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/92690","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Engineering hydrogel environments to direct cell fate","abstract":"The advent of hydrogels for biological applications has sparked interest in the both the medical and engineering community in recent years as a means to investigate cellular level processes. An area that has shown promising application of hydrogel materials has been in the study of stem cell development. Proven that the microenvironment of the stem cell plays a critical role in its development, hydrogels can closely mimic the intricate physical, biological, and chemical landscape encompassing various cell types. Hydrogels are simply polymer network with large water content, and their robust nature allows versatile manipulation. From patterning different geometries, coating with adhering proteins or bioactive peptides, and construction of complex physiological architectures, hydrogels provide a wide set of tools to investigate stem cell development. Interested in a wide range of questions in cellular development, we explored effects of different aspects of the environment. We patterned polyacrylamide hydrogels with patterns similar topologically to tissue architecture to observe increased conversion, used this system with it’s tunable compliance to study natural biochemical lipid derivatives to observe significant cellular response, and created PEG based 3D coculture environments to study the interface of cell types for increased angiogenesis.","abstract_html":"The advent of hydrogels for biological applications has sparked interest in the both the medical and engineering community in recent years as a means to investigate cellular level processes. An area that has shown promising application of hydrogel materials has been in the study of stem cell development. Proven that the microenvironment of the stem cell plays a critical role in its development, hydrogels can closely mimic the intricate physical, biological, and chemical landscape encompassing various cell types. Hydrogels are simply polymer network with large water content, and their robust nature allows versatile manipulation. From patterning different geometries, coating with adhering proteins or bioactive peptides, and construction of complex physiological architectures, hydrogels provide a wide set of tools to investigate stem cell development. Interested in a wide range of questions in cellular development, we explored effects of different aspects of the environment. We patterned polyacrylamide hydrogels with patterns similar topologically to tissue architecture to observe increased conversion, used this system with it’s tunable compliance to study natural biochemical lipid derivatives to observe significant cellular response, and created PEG based 3D coculture environments to study the interface of cell types for increased angiogenesis.","abstract_has_math":false,"creators":["Mo, Samuel H"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Materials Science & Engr","degree_department":null,"school":null,"contributors":["Kilian, Kristopher A."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2016,"date_issued":"2016-11-10T17:49:21Z","date_published":"2016-11-10T17:49:21Z","updated_at":"2026-07-22T22:26:35Z","subjects":["Hydrogels, Biomaterials"],"languages":["en"],"rights":["Copyright 2016 Samuel Mo"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/92690","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Kilian, Kristopher A."]},{"key":"dc:creator","label":"Author","values":["Mo, Samuel H"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2016-11-10T17:49:21Z","2016-06-06","2016-08"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Materials Science & Engr"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Hydrogels, Biomaterials"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2016 Samuel Mo"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/92690"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The advent of hydrogels for biological applications has sparked interest in the both the medical and engineering community in recent years as a means to investigate cellular level processes. An area that has shown promising application of hydrogel materials has been in the study of stem cell development. Proven that the microenvironment of the stem cell plays a critical role in its development, hydrogels can closely mimic the intricate physical, biological, and chemical landscape encompassing various cell types. Hydrogels are simply polymer network with large water content, and their robust nature allows versatile manipulation. From patterning different geometries, coating with adhering proteins or bioactive peptides, and construction of complex physiological architectures, hydrogels provide a wide set of tools to investigate stem cell development. Interested in a wide range of questions in cellular development, we explored effects of different aspects of the environment. We patterned polyacrylamide hydrogels with patterns similar topologically to tissue architecture to observe increased conversion, used this system with it’s tunable compliance to study natural biochemical lipid derivatives to observe significant cellular response, and created PEG based 3D coculture environments to study the interface of cell types for increased angiogenesis.","Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2016-11-09 without embargo terms","The student, Samuel Mo, accepted the attached license on 2016-04-29 at 16:52.","The student, Samuel Mo, submitted this Thesis for approval on 2016-04-29 at 16:54.","This Thesis was approved for publication on 2016-06-06 at 11:17.","DSpace SAF Submission Ingestion Package generated from Vireo submission #9593 on 2016-11-09 at 10:19:18","Made available in DSpace on 2016-11-10T17:49:21Z (GMT). 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Proven that the microenvironment of the stem cell plays a critical role in its development, hydrogels can closely mimic the intricate physical, biological, and chemical landscape encompassing various cell types. Hydrogels are simply polymer network with large water content, and their robust nature allows versatile manipulation. From patterning different geometries, coating with adhering proteins or bioactive peptides, and construction of complex physiological architectures, hydrogels provide a wide set of tools to investigate stem cell development. Interested in a wide range of questions in cellular development, we explored effects of different aspects of the environment. We patterned polyacrylamide hydrogels with patterns similar topologically to tissue architecture to observe increased conversion, used this system with it’s tunable compliance to study natural biochemical lipid derivatives to observe significant cellular response, and created PEG based 3D coculture environments to study the interface of cell types for increased angiogenesis.","Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2016-11-09 without embargo terms","The student, Samuel Mo, accepted the attached license on 2016-04-29 at 16:52.","The student, Samuel Mo, submitted this Thesis for approval on 2016-04-29 at 16:54.","This Thesis was approved for publication on 2016-06-06 at 11:17.","DSpace SAF Submission Ingestion Package generated from Vireo submission #9593 on 2016-11-09 at 10:19:18","Made available in DSpace on 2016-11-10T17:49:21Z (GMT). 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