{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/90657"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/90657","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Strength of family bond predicts disrupted neural habituation to visual familial threat in adolescence","abstract":"BACKGROUND: Familial stressors, such as low family connectedness, confer risk for affective pathologies, yet little is known regarding how they uniquely impinge on neural systems involved in adaptive threat processing. METHODS: MVPA analysis of fMRI data was used in a novel way to measure disrupted neural habituation in a threat network comprising nodes of the limbic system across several classes of stimuli including unpredictable familial and nonfamilial threat and joy. In the present longitudinal design, measures of family connectedness were collected for adolescents (n=22, age=14.38) at the study's outset, and a year later, a neuroimaging protocol was carried out. RESULTS: For those low in family connectedness, elevated sensitivity scores derived from MVPA reflected that the encoding of unpredictable familial threat was more stable across time, indicating reduced habituation to familial threat. Reduced habituation was specific to familial threat, as null relationships were found between family connectedness and MVPA sensitivity to familial joy, nonfamilial threat, and nonfamilial joy. CONCLUSIONS: Results suggest that familial stressors may confer specific biological disruptions to risk-related stimuli, in this case, threatening maternal images. The present novel experimental paradigm and use of MVPA provide the foundation for further exploring how MVPA can be used to test for selective habituation to specific stimuli germane to other environmental risk factors for internalizing pathologies.","abstract_html":"BACKGROUND: Familial stressors, such as low family connectedness, confer risk for affective pathologies, yet little is known regarding how they uniquely impinge on neural systems involved in adaptive threat processing. METHODS: MVPA analysis of fMRI data was used in a novel way to measure disrupted neural habituation in a threat network comprising nodes of the limbic system across several classes of stimuli including unpredictable familial and nonfamilial threat and joy. In the present longitudinal design, measures of family connectedness were collected for adolescents (n=22, age=14.38) at the study's outset, and a year later, a neuroimaging protocol was carried out. RESULTS: For those low in family connectedness, elevated sensitivity scores derived from MVPA reflected that the encoding of unpredictable familial threat was more stable across time, indicating reduced habituation to familial threat. Reduced habituation was specific to familial threat, as null relationships were found between family connectedness and MVPA sensitivity to familial joy, nonfamilial threat, and nonfamilial joy. CONCLUSIONS: Results suggest that familial stressors may confer specific biological disruptions to risk-related stimuli, in this case, threatening maternal images. The present novel experimental paradigm and use of MVPA provide the foundation for further exploring how MVPA can be used to test for selective habituation to specific stimuli germane to other environmental risk factors for internalizing pathologies.","abstract_has_math":false,"creators":["Sharp, Paul Benjamin"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.A.","degree_level":"Thesis","degree_discipline":"Psychology","degree_department":null,"school":null,"contributors":["Heller, Wendy","Telzer, Eva H."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2016,"date_issued":"2016-07-07T19:58:06Z","date_published":"2016-07-07T19:58:06Z","updated_at":"2026-07-22T22:26:34Z","subjects":["Multivoxel pattern analysis (MVPA)","Anxiety","Amygdala","Family Stressors","Habituation"],"languages":["en"],"rights":["Copyright 2016 Paul Sharp"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/90657","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Heller, Wendy","Telzer, Eva H."]},{"key":"dc:creator","label":"Author","values":["Sharp, Paul Benjamin"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2016-07-07T19:58:06Z","2016-04-26","2016-05"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Psychology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.A."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Multivoxel pattern analysis (MVPA)","Anxiety","Amygdala","Family Stressors","Habituation"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2016 Paul Sharp"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/90657"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["BACKGROUND: Familial stressors, such as low family connectedness, confer risk for affective pathologies, yet little is known regarding how they uniquely impinge on neural systems involved in adaptive threat processing. METHODS: MVPA analysis of fMRI data was used in a novel way to measure disrupted neural habituation in a threat network comprising nodes of the limbic system across several classes of stimuli including unpredictable familial and nonfamilial threat and joy. In the present longitudinal design, measures of family connectedness were collected for adolescents (n=22, age=14.38) at the study's outset, and a year later, a neuroimaging protocol was carried out. RESULTS: For those low in family connectedness, elevated sensitivity scores derived from MVPA reflected that the encoding of unpredictable familial threat was more stable across time, indicating reduced habituation to familial threat. Reduced habituation was specific to familial threat, as null relationships were found between family connectedness and MVPA sensitivity to familial joy, nonfamilial threat, and nonfamilial joy. CONCLUSIONS: Results suggest that familial stressors may confer specific biological disruptions to risk-related stimuli, in this case, threatening maternal images. The present novel experimental paradigm and use of MVPA provide the foundation for further exploring how MVPA can be used to test for selective habituation to specific stimuli germane to other environmental risk factors for internalizing pathologies.","Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2016-07-07 without embargo terms","The student, Paul Sharp, accepted the attached license on 2016-04-26 at 12:44.","The student, Paul Sharp, submitted this Thesis for approval on 2016-04-26 at 12:50.","This Thesis was approved for publication on 2016-04-26 at 14:10.","DSpace SAF Submission Ingestion Package generated from Vireo submission #9509 on 2016-07-07 at 13:33:23","Made available in DSpace on 2016-07-07T19:58:06Z (GMT). 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METHODS: MVPA analysis of fMRI data was used in a novel way to measure disrupted neural habituation in a threat network comprising nodes of the limbic system across several classes of stimuli including unpredictable familial and nonfamilial threat and joy. In the present longitudinal design, measures of family connectedness were collected for adolescents (n=22, age=14.38) at the study's outset, and a year later, a neuroimaging protocol was carried out. RESULTS: For those low in family connectedness, elevated sensitivity scores derived from MVPA reflected that the encoding of unpredictable familial threat was more stable across time, indicating reduced habituation to familial threat. Reduced habituation was specific to familial threat, as null relationships were found between family connectedness and MVPA sensitivity to familial joy, nonfamilial threat, and nonfamilial joy. CONCLUSIONS: Results suggest that familial stressors may confer specific biological disruptions to risk-related stimuli, in this case, threatening maternal images. The present novel experimental paradigm and use of MVPA provide the foundation for further exploring how MVPA can be used to test for selective habituation to specific stimuli germane to other environmental risk factors for internalizing pathologies.","Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2016-07-07 without embargo terms","The student, Paul Sharp, accepted the attached license on 2016-04-26 at 12:44.","The student, Paul Sharp, submitted this Thesis for approval on 2016-04-26 at 12:50.","This Thesis was approved for publication on 2016-04-26 at 14:10.","DSpace SAF Submission Ingestion Package generated from Vireo submission #9509 on 2016-07-07 at 13:33:23","Made available in DSpace on 2016-07-07T19:58:06Z (GMT). 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