{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/89156"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/89156","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Investigating lipid corona formation onto polystyrene nanoparticles through fluorescence correlation spectroscopy","abstract":"When a nanoparticle enters a biological environment, molecules are known to adsorb on the surface forming a corona. Systematically studying the formation of a corona is important to develop knowledge as to how a given nanomaterial will transform once entering a biological environment. A common interface met by a nanomaterial in the human body is the cell membrane, which is composed of phospholipid bilayer. Fluorescence correlation spectroscopy (FCS) is a promising tool that can be used to probe nanoparticle-cell interactions. FCS experiments focusing on exposure of lipid vesicles to different polystyrene nanoparticles indicate possible formation of a lipid corona. Further study varying the nanoparticle charge and lipid vesicle fluidity can help elucidate the mechanism of lipid corona formation. Such work can provide insight into understanding the complex nature of the nano-bio interface.","abstract_html":"When a nanoparticle enters a biological environment, molecules are known to adsorb on the surface forming a corona. Systematically studying the formation of a corona is important to develop knowledge as to how a given nanomaterial will transform once entering a biological environment. A common interface met by a nanomaterial in the human body is the cell membrane, which is composed of phospholipid bilayer. Fluorescence correlation spectroscopy (FCS) is a promising tool that can be used to probe nanoparticle-cell interactions. FCS experiments focusing on exposure of lipid vesicles to different polystyrene nanoparticles indicate possible formation of a lipid corona. Further study varying the nanoparticle charge and lipid vesicle fluidity can help elucidate the mechanism of lipid corona formation. Such work can provide insight into understanding the complex nature of the nano-bio interface.","abstract_has_math":false,"creators":["Jacob, Lisa"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Murphy, Catherine J."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2016,"date_issued":"2016-03-02T20:24:17Z","date_published":"2016-03-02T20:24:17Z","updated_at":"2026-07-22T22:26:32Z","subjects":["nano-bio interactions","fluorescence correlation spectroscopy","lipid corona"],"languages":["en"],"rights":["Copyright 2015 Lisa Jacob"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/89156","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Murphy, Catherine J."]},{"key":"dc:creator","label":"Author","values":["Jacob, Lisa"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2016-03-02T20:24:17Z","2018-03-03T10:15:25Z","2015-12-08","2015-12"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["nano-bio interactions","fluorescence correlation spectroscopy","lipid corona"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2015 Lisa Jacob"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/89156"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["When a nanoparticle enters a biological environment, molecules are known to adsorb on the surface forming a corona. 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Systematically studying the formation of a corona is important to develop knowledge as to how a given nanomaterial will transform once entering a biological environment. A common interface met by a nanomaterial in the human body is the cell membrane, which is composed of phospholipid bilayer. Fluorescence correlation spectroscopy (FCS) is a promising tool that can be used to probe nanoparticle-cell interactions. FCS experiments focusing on exposure of lipid vesicles to different polystyrene nanoparticles indicate possible formation of a lipid corona. Further study varying the nanoparticle charge and lipid vesicle fluidity can help elucidate the mechanism of lipid corona formation. 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