{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/88319"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/88319","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Inverted compound eye camera for second generation MRI compatible SPECT system","abstract":"In this work, we will evaluate a novel design of the second-generation MRI compatible SPECT system, MRC-SPECT-II, based on an inverted compound eye (ICE) gamma camera concept inspired by compound eyes often found in small invertebrates. The MRC-SPECT II system is constructed with a total of 24 ICE-camera panels that consists of a very large number (up to 1500) of independent micro-pinhole-gamma-camera-elements (MCEs) looking at the object. Each MCE only covers a narrow view angular through the object space. This system design offers several unique advantages for the MR-compatible SPECT imaging application. First, this design allows for a greatly improved system sensitivity over the more conventional pinhole SPECT system designs. Our Monte Carlo study showed that the MRC-SPECT-II system could deliver a peak geometry efficiency of around 1.5% (as compared to the typical levels of 0.1%-0.01% found in modern pre-clinical SPECT instrumentations), while maintaining an excellent spatial resolution of around 0.5 mm and a single-position field-of-view (FOV) of 1 cm. Second, the ICE camera design also allows for an ultra-compact detection system that helps to fit the MRC-SPECT-II system inside most of high-field pre-clinical MR system. Furthermore, given the very large number of micro-camera-elements pointing towards the object, the MRC-SPECT-II system design offers a super-rich angular sampling of the object. Finally, an ICE-camera-based SPECT system typically uses a highly de-magnifying geometry that requires a reduced detector volume, compared to typical pinhole SPECT system that relies on magnifying geometry to achieve a high spatial resolution. This offers the practical benefit of potentially lower construction cost. In this study, we used Monte Carlo studies to demonstrate the performance benefit of the MRC-SPECT-II system over the existing MRC-SPECT system that we have developed in our lab. We have also expanded the Monte Carlo study to evaluate the use of the ICE-SPECT concept for imaging larger objects, human brain.","abstract_html":"In this work, we will evaluate a novel design of the second-generation MRI compatible SPECT system, MRC-SPECT-II, based on an inverted compound eye (ICE) gamma camera concept inspired by compound eyes often found in small invertebrates. The MRC-SPECT II system is constructed with a total of 24 ICE-camera panels that consists of a very large number (up to 1500) of independent micro-pinhole-gamma-camera-elements (MCEs) looking at the object. Each MCE only covers a narrow view angular through the object space. This system design offers several unique advantages for the MR-compatible SPECT imaging application. First, this design allows for a greatly improved system sensitivity over the more conventional pinhole SPECT system designs. Our Monte Carlo study showed that the MRC-SPECT-II system could deliver a peak geometry efficiency of around 1.5% (as compared to the typical levels of 0.1%-0.01% found in modern pre-clinical SPECT instrumentations), while maintaining an excellent spatial resolution of around 0.5 mm and a single-position field-of-view (FOV) of 1 cm. Second, the ICE camera design also allows for an ultra-compact detection system that helps to fit the MRC-SPECT-II system inside most of high-field pre-clinical MR system. Furthermore, given the very large number of micro-camera-elements pointing towards the object, the MRC-SPECT-II system design offers a super-rich angular sampling of the object. Finally, an ICE-camera-based SPECT system typically uses a highly de-magnifying geometry that requires a reduced detector volume, compared to typical pinhole SPECT system that relies on magnifying geometry to achieve a high spatial resolution. This offers the practical benefit of potentially lower construction cost. In this study, we used Monte Carlo studies to demonstrate the performance benefit of the MRC-SPECT-II system over the existing MRC-SPECT system that we have developed in our lab. We have also expanded the Monte Carlo study to evaluate the use of the ICE-SPECT concept for imaging larger objects, human brain.","abstract_has_math":false,"creators":["Lai, Xiaochun"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Nuclear, Plasma, & Radiolgcical Engineering","degree_department":null,"school":null,"contributors":["Meng, Ling Jian"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-29T21:08:26Z","date_published":"2015-09-29T21:08:26Z","updated_at":"2026-07-22T22:26:32Z","subjects":["Cadmium Telluride (CdTe) semiconductor detector","single-photon emission computerized tomography (SPECT)/MRI","Compound Eye"],"languages":["en"],"rights":["Copyright 2015 Xiaochun Lai"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/88319","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Meng, Ling Jian"]},{"key":"dc:creator","label":"Author","values":["Lai, Xiaochun"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-09-29T21:08:26Z","2017-09-30T09:15:18Z","2015-08","2015-07-23","2015-8"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Nuclear, Plasma, & Radiolgcical Engineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Cadmium Telluride (CdTe) semiconductor detector","single-photon emission computerized tomography (SPECT)/MRI","Compound Eye"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2015 Xiaochun Lai"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/88319"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["In this work, we will evaluate a novel design of the second-generation MRI compatible SPECT system, MRC-SPECT-II, based on an inverted compound eye (ICE) gamma camera concept inspired by compound eyes often found in small invertebrates. The MRC-SPECT II system is constructed with a total of 24 ICE-camera panels that consists of a very large number (up to 1500) of independent micro-pinhole-gamma-camera-elements (MCEs) looking at the object. Each MCE only covers a narrow view angular through the object space. This system design offers several unique advantages for the MR-compatible SPECT imaging application. First, this design allows for a greatly improved system sensitivity over the more conventional pinhole SPECT system designs. Our Monte Carlo study showed that the MRC-SPECT-II system could deliver a peak geometry efficiency of around 1.5% (as compared to the typical levels of 0.1%-0.01% found in modern pre-clinical SPECT instrumentations), while maintaining an excellent spatial resolution of around 0.5 mm and a single-position field-of-view (FOV) of 1 cm. Second, the ICE camera design also allows for an ultra-compact detection system that helps to fit the MRC-SPECT-II system inside most of high-field pre-clinical MR system. Furthermore, given the very large number of micro-camera-elements pointing towards the object, the MRC-SPECT-II system design offers a super-rich angular sampling of the object. Finally, an ICE-camera-based SPECT system typically uses a highly de-magnifying geometry that requires a reduced detector volume, compared to typical pinhole SPECT system that relies on magnifying geometry to achieve a high spatial resolution. This offers the practical benefit of potentially lower construction cost. In this study, we used Monte Carlo studies to demonstrate the performance benefit of the MRC-SPECT-II system over the existing MRC-SPECT system that we have developed in our lab. We have also expanded the Monte Carlo study to evaluate the use of the ICE-SPECT concept for imaging larger objects, human brain.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2017-08-01","The student, Xiaochun Lai, accepted the attached license on 2015-07-23 at 10:28.","The student, Xiaochun Lai, submitted this Thesis for approval on 2015-07-23 at 10:28.","This Thesis was approved for publication on 2015-07-23 at 13:26.","DSpace SAF Submission Ingestion Package generated from Vireo submission #8628 on 2015-09-29 at 15:06:53","Made available in DSpace on 2015-09-29T21:08:26Z (GMT). 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The MRC-SPECT II system is constructed with a total of 24 ICE-camera panels that consists of a very large number (up to 1500) of independent micro-pinhole-gamma-camera-elements (MCEs) looking at the object. Each MCE only covers a narrow view angular through the object space. This system design offers several unique advantages for the MR-compatible SPECT imaging application. First, this design allows for a greatly improved system sensitivity over the more conventional pinhole SPECT system designs. Our Monte Carlo study showed that the MRC-SPECT-II system could deliver a peak geometry efficiency of around 1.5% (as compared to the typical levels of 0.1%-0.01% found in modern pre-clinical SPECT instrumentations), while maintaining an excellent spatial resolution of around 0.5 mm and a single-position field-of-view (FOV) of 1 cm. Second, the ICE camera design also allows for an ultra-compact detection system that helps to fit the MRC-SPECT-II system inside most of high-field pre-clinical MR system. Furthermore, given the very large number of micro-camera-elements pointing towards the object, the MRC-SPECT-II system design offers a super-rich angular sampling of the object. Finally, an ICE-camera-based SPECT system typically uses a highly de-magnifying geometry that requires a reduced detector volume, compared to typical pinhole SPECT system that relies on magnifying geometry to achieve a high spatial resolution. This offers the practical benefit of potentially lower construction cost. In this study, we used Monte Carlo studies to demonstrate the performance benefit of the MRC-SPECT-II system over the existing MRC-SPECT system that we have developed in our lab. We have also expanded the Monte Carlo study to evaluate the use of the ICE-SPECT concept for imaging larger objects, human brain.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2017-08-01","The student, Xiaochun Lai, accepted the attached license on 2015-07-23 at 10:28.","The student, Xiaochun Lai, submitted this Thesis for approval on 2015-07-23 at 10:28.","This Thesis was approved for publication on 2015-07-23 at 13:26.","DSpace SAF Submission Ingestion Package generated from Vireo submission #8628 on 2015-09-29 at 15:06:53","Made available in DSpace on 2015-09-29T21:08:26Z (GMT). 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