{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/88254"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/88254","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"I. Facile preparation of ortho-fluorophenols from non-aromatic precursors and investigation of applications to fluorine-18 labeling II. Resin-supported silyl ester precursors for kit-like radiolabeling with fluorine-18","abstract":"Molecular imaging is a technique that can be used to visualize complex biochemical processes without perturbing living organisms, and it has been playing increasingly important roles for the early detection of disease states and monitoring the results of therapies. Among molecular imaging techniques, Positron Emission Tomography (PET) has significant advantages compared with other techniques, which includes its high sensitivity and high spatial resolution, and most importantly, its ability to provide functional information, whereas MRI or CT provide largely anatomical information. Among commonly used positron-emitting radionuclides, fluorine-18 has a number of preferred characteristics which are, 1) longest half-life, 109 minutes, 2) lowest maximum energy and 3) purest mode of decay. However, F-18 radiolabeling method is still underdeveloped, and thus, practical radiosyntheses are limited to nucleophilic substitution, especially at alkyl positions. Therefore, to extend the utility of F-18 for PET radiotracers, novel radiolabeling methods with F-18 that enable the preparation of a wide variety of radiotracers, rapidly, efficiently and conveniently are in highly demand in the field of radiochemistry. Chapter 1 presents an introduction of PET imaging techniques, and outlines the basics of F-18 radiochemistry, which focuses on the synthetic difficulties associated with the nature of fluoride and especially F-18. It also highlights the current efforts placed on the development of novel fluorination methods toward F-18 radiosynthesis, especially C-F bond formation on electron-rich aromatic rings and use of fluorophilic elements for rapid preparation of radiotracers. Chapter 2 discusses the development of a facile a fluorination method that produces ortho-fluorophenols from non-aromatic precursors. We have found that α-diazocyclohexenones undergo halofluorination with fluoride ion as fluoride source, and the following hydrohalide elimination and tautomerization afford ortho-fluorophenols rapidly. The translation to F-18 radiolabeling was achieved using organic soluble phase transfer catalysis under carrier-added conditions. Although labeling under non-carrier-added conditions is still a work in progress, our current progress points to a new approach to label electron-rich aromatic rings rapidly and at high specific activity (SA). Chapter 3 discusses the development of a kit-like radiosynthetic method using a resin-supported silicon based precursor. We have found that silyl esters have significant advantages over previously reported methods; they undergo F-18 incorporation under very mild conditions, with F-18 water straight from the cyclotron used without any drying. We further developed the resin-supported method which enables simple purification of the radiotracer. The utility of this approach is showcased in three main area of research: prosthetic groups, small molecules and peptides.","abstract_html":"Molecular imaging is a technique that can be used to visualize complex biochemical processes without perturbing living organisms, and it has been playing increasingly important roles for the early detection of disease states and monitoring the results of therapies. Among molecular imaging techniques, Positron Emission Tomography (PET) has significant advantages compared with other techniques, which includes its high sensitivity and high spatial resolution, and most importantly, its ability to provide functional information, whereas MRI or CT provide largely anatomical information. Among commonly used positron-emitting radionuclides, fluorine-18 has a number of preferred characteristics which are, 1) longest half-life, 109 minutes, 2) lowest maximum energy and 3) purest mode of decay. However, F-18 radiolabeling method is still underdeveloped, and thus, practical radiosyntheses are limited to nucleophilic substitution, especially at alkyl positions. Therefore, to extend the utility of F-18 for PET radiotracers, novel radiolabeling methods with F-18 that enable the preparation of a wide variety of radiotracers, rapidly, efficiently and conveniently are in highly demand in the field of radiochemistry. Chapter 1 presents an introduction of PET imaging techniques, and outlines the basics of F-18 radiochemistry, which focuses on the synthetic difficulties associated with the nature of fluoride and especially F-18. It also highlights the current efforts placed on the development of novel fluorination methods toward F-18 radiosynthesis, especially C-F bond formation on electron-rich aromatic rings and use of fluorophilic elements for rapid preparation of radiotracers. Chapter 2 discusses the development of a facile a fluorination method that produces ortho-fluorophenols from non-aromatic precursors. We have found that α-diazocyclohexenones undergo halofluorination with fluoride ion as fluoride source, and the following hydrohalide elimination and tautomerization afford ortho-fluorophenols rapidly. The translation to F-18 radiolabeling was achieved using organic soluble phase transfer catalysis under carrier-added conditions. Although labeling under non-carrier-added conditions is still a work in progress, our current progress points to a new approach to label electron-rich aromatic rings rapidly and at high specific activity (SA). Chapter 3 discusses the development of a kit-like radiosynthetic method using a resin-supported silicon based precursor. We have found that silyl esters have significant advantages over previously reported methods; they undergo F-18 incorporation under very mild conditions, with F-18 water straight from the cyclotron used without any drying. We further developed the resin-supported method which enables simple purification of the radiotracer. The utility of this approach is showcased in three main area of research: prosthetic groups, small molecules and peptides.","abstract_has_math":false,"creators":["Yasui, Norio"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Katzenellenbogen, John A.","Hergenrother, Paul J.","Lu, Yi","van der Donk, Wilfred A."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-29T21:02:53Z","date_published":"2015-09-29T21:02:53Z","updated_at":"2026-07-22T22:26:31Z","subjects":["radiochemistry","fluorine-18","fluorination","diazoketone","silyl ester","resin-supported"],"languages":["en"],"rights":["Copyright 2015 Norio Yasui"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/88254","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Katzenellenbogen, John A.","Hergenrother, Paul J.","Lu, Yi","van der Donk, Wilfred A."]},{"key":"dc:creator","label":"Author","values":["Yasui, Norio"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-09-29T21:02:53Z","2017-09-30T09:15:22Z","2015-08","2015-07-01","2015-8"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["radiochemistry","fluorine-18","fluorination","diazoketone","silyl ester","resin-supported"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2015 Norio Yasui"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/88254"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Molecular imaging is a technique that can be used to visualize complex biochemical processes without perturbing living organisms, and it has been playing increasingly important roles for the early detection of disease states and monitoring the results of therapies. Among molecular imaging techniques, Positron Emission Tomography (PET) has significant advantages compared with other techniques, which includes its high sensitivity and high spatial resolution, and most importantly, its ability to provide functional information, whereas MRI or CT provide largely anatomical information. Among commonly used positron-emitting radionuclides, fluorine-18 has a number of preferred characteristics which are, 1) longest half-life, 109 minutes, 2) lowest maximum energy and 3) purest mode of decay. However, F-18 radiolabeling method is still underdeveloped, and thus, practical radiosyntheses are limited to nucleophilic substitution, especially at alkyl positions. Therefore, to extend the utility of F-18 for PET radiotracers, novel radiolabeling methods with F-18 that enable the preparation of a wide variety of radiotracers, rapidly, efficiently and conveniently are in highly demand in the field of radiochemistry. Chapter 1 presents an introduction of PET imaging techniques, and outlines the basics of F-18 radiochemistry, which focuses on the synthetic difficulties associated with the nature of fluoride and especially F-18. It also highlights the current efforts placed on the development of novel fluorination methods toward F-18 radiosynthesis, especially C-F bond formation on electron-rich aromatic rings and use of fluorophilic elements for rapid preparation of radiotracers. Chapter 2 discusses the development of a facile a fluorination method that produces ortho-fluorophenols from non-aromatic precursors. We have found that α-diazocyclohexenones undergo halofluorination with fluoride ion as fluoride source, and the following hydrohalide elimination and tautomerization afford ortho-fluorophenols rapidly. The translation to F-18 radiolabeling was achieved using organic soluble phase transfer catalysis under carrier-added conditions. Although labeling under non-carrier-added conditions is still a work in progress, our current progress points to a new approach to label electron-rich aromatic rings rapidly and at high specific activity (SA). Chapter 3 discusses the development of a kit-like radiosynthetic method using a resin-supported silicon based precursor. We have found that silyl esters have significant advantages over previously reported methods; they undergo F-18 incorporation under very mild conditions, with F-18 water straight from the cyclotron used without any drying. We further developed the resin-supported method which enables simple purification of the radiotracer. The utility of this approach is showcased in three main area of research: prosthetic groups, small molecules and peptides.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2017-08-01","The student, Norio Yasui, accepted the attached license on 2015-06-30 at 13:33.","The student, Norio Yasui, submitted this Dissertation for approval on 2015-06-30 at 13:49.","This Dissertation was approved for publication on 2015-07-01 at 11:47.","DSpace SAF Submission Ingestion Package generated from Vireo submission #8302 on 2015-09-29 at 15:05:18","Made available in DSpace on 2015-09-29T21:02:53Z (GMT). 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Among molecular imaging techniques, Positron Emission Tomography (PET) has significant advantages compared with other techniques, which includes its high sensitivity and high spatial resolution, and most importantly, its ability to provide functional information, whereas MRI or CT provide largely anatomical information. Among commonly used positron-emitting radionuclides, fluorine-18 has a number of preferred characteristics which are, 1) longest half-life, 109 minutes, 2) lowest maximum energy and 3) purest mode of decay. However, F-18 radiolabeling method is still underdeveloped, and thus, practical radiosyntheses are limited to nucleophilic substitution, especially at alkyl positions. Therefore, to extend the utility of F-18 for PET radiotracers, novel radiolabeling methods with F-18 that enable the preparation of a wide variety of radiotracers, rapidly, efficiently and conveniently are in highly demand in the field of radiochemistry. Chapter 1 presents an introduction of PET imaging techniques, and outlines the basics of F-18 radiochemistry, which focuses on the synthetic difficulties associated with the nature of fluoride and especially F-18. It also highlights the current efforts placed on the development of novel fluorination methods toward F-18 radiosynthesis, especially C-F bond formation on electron-rich aromatic rings and use of fluorophilic elements for rapid preparation of radiotracers. Chapter 2 discusses the development of a facile a fluorination method that produces ortho-fluorophenols from non-aromatic precursors. We have found that α-diazocyclohexenones undergo halofluorination with fluoride ion as fluoride source, and the following hydrohalide elimination and tautomerization afford ortho-fluorophenols rapidly. The translation to F-18 radiolabeling was achieved using organic soluble phase transfer catalysis under carrier-added conditions. Although labeling under non-carrier-added conditions is still a work in progress, our current progress points to a new approach to label electron-rich aromatic rings rapidly and at high specific activity (SA). Chapter 3 discusses the development of a kit-like radiosynthetic method using a resin-supported silicon based precursor. We have found that silyl esters have significant advantages over previously reported methods; they undergo F-18 incorporation under very mild conditions, with F-18 water straight from the cyclotron used without any drying. We further developed the resin-supported method which enables simple purification of the radiotracer. The utility of this approach is showcased in three main area of research: prosthetic groups, small molecules and peptides.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2017-08-01","The student, Norio Yasui, accepted the attached license on 2015-06-30 at 13:33.","The student, Norio Yasui, submitted this Dissertation for approval on 2015-06-30 at 13:49.","This Dissertation was approved for publication on 2015-07-01 at 11:47.","DSpace SAF Submission Ingestion Package generated from Vireo submission #8302 on 2015-09-29 at 15:05:18","Made available in DSpace on 2015-09-29T21:02:53Z (GMT). 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