{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/88165"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/88165","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Thalidomide-induced teratogenesis in gray short-tailed opossums (Monodelphis domestica)","abstract":"From 1957 to 1962, Thalidomide was prescribed to pregnant women as an antiemetic and was later discovered to cause serious birth defects. Thalidomide is currently being prescribed to treat erythema nodosum leprosum and multiple melanoma, and is being considered for other anti-angiogenic applications. This is of concern, as the mechanisms by which thalidomide disrupts development remain largely unknown. This lack of knowledge is largely due to the absence of an appropriate model mammalian system. Traditional mammal models, such as rats and mice, are resistant to the teratogenic properties of thalidomide. We propose to develop the gray short-tailed opossum (Monodelphis domestica) as a novel mammalian to study thalidomide teratogenesis. In M. domestica we have successfully recreated most morphological defects found in human thalidomide victims. Through RNA sequencing, we have also identified two gene that may play a significant role in the mechanism of thalidomide induced birth defects.","abstract_html":"From 1957 to 1962, Thalidomide was prescribed to pregnant women as an antiemetic and was later discovered to cause serious birth defects. Thalidomide is currently being prescribed to treat erythema nodosum leprosum and multiple melanoma, and is being considered for other anti-angiogenic applications. This is of concern, as the mechanisms by which thalidomide disrupts development remain largely unknown. This lack of knowledge is largely due to the absence of an appropriate model mammalian system. Traditional mammal models, such as rats and mice, are resistant to the teratogenic properties of thalidomide. We propose to develop the gray short-tailed opossum (Monodelphis domestica) as a novel mammalian to study thalidomide teratogenesis. In M. domestica we have successfully recreated most morphological defects found in human thalidomide victims. Through RNA sequencing, we have also identified two gene that may play a significant role in the mechanism of thalidomide induced birth defects.","abstract_has_math":false,"creators":["Sorensen, Daniel Wood"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Biology","degree_department":null,"school":null,"contributors":["Sears, Karen E."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-29T20:49:45Z","date_published":"2015-09-29T20:49:45Z","updated_at":"2026-07-22T22:26:31Z","subjects":["Thalidomide","Monodelphis"],"languages":["en"],"rights":["Copyright 2015 Daniel Sorensen"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/88165","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Sears, Karen E."]},{"key":"dc:creator","label":"Author","values":["Sorensen, Daniel Wood"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-09-29T20:49:45Z","2017-09-30T09:15:18Z","2015-08","2015-07-07","2015-8"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Biology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Thalidomide","Monodelphis"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2015 Daniel Sorensen"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/88165"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["From 1957 to 1962, Thalidomide was prescribed to pregnant women as an antiemetic and was later discovered to cause serious birth defects. 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Through RNA sequencing, we have also identified two gene that may play a significant role in the mechanism of thalidomide induced birth defects.","Submission published under a 24 month embargo labeled 'U of I only', the embargo will last until 2017-08-01","The student, Daniel Sorensen, accepted the attached license on 2015-07-07 at 09:55.","The student, Daniel Sorensen, submitted this Thesis for approval on 2015-07-07 at 10:01.","This Thesis was approved for publication on 2015-07-07 at 11:12.","DSpace SAF Submission Ingestion Package generated from Vireo submission #8361 on 2015-09-29 at 14:59:11","Made available in DSpace on 2015-09-29T20:49:45Z (GMT). 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Thalidomide is currently being prescribed to treat erythema nodosum leprosum and multiple melanoma, and is being considered for other anti-angiogenic applications. This is of concern, as the mechanisms by which thalidomide disrupts development remain largely unknown. This lack of knowledge is largely due to the absence of an appropriate model mammalian system. Traditional mammal models, such as rats and mice, are resistant to the teratogenic properties of thalidomide. We propose to develop the gray short-tailed opossum (Monodelphis domestica) as a novel mammalian to study thalidomide teratogenesis. In M. domestica we have successfully recreated most morphological defects found in human thalidomide victims. Through RNA sequencing, we have also identified two gene that may play a significant role in the mechanism of thalidomide induced birth defects.","Submission published under a 24 month embargo labeled 'U of I only', the embargo will last until 2017-08-01","The student, Daniel Sorensen, accepted the attached license on 2015-07-07 at 09:55.","The student, Daniel Sorensen, submitted this Thesis for approval on 2015-07-07 at 10:01.","This Thesis was approved for publication on 2015-07-07 at 11:12.","DSpace SAF Submission Ingestion Package generated from Vireo submission #8361 on 2015-09-29 at 14:59:11","Made available in DSpace on 2015-09-29T20:49:45Z (GMT). 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