{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/87870"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/87870","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Synaptic Plasticity in the Cerebral Cortex of Fragile X Knockout Mice","abstract":"In the next experiments, the ultrastructure of the visual cortex was examined in young Fmr1 knockout and wildtype mice. The rate of developmental synaptogenesis between the two genotypes was similar, but Fmr1 knockout mice exhibited levels of synaptic protein synthesis lower than those of wildtype mice. The role of FMRP in experience-dependent brain plasticity was also assessed. FMRP expression in the rat occipital cortex increases following exposure to a complex environment, but measures of synaptogenesis in Fmr1 knockout mice raised in this environment have been inconclusive. FMRP appears to be important for some, but not all forms of synaptic plasticity.","abstract_html":"In the next experiments, the ultrastructure of the visual cortex was examined in young Fmr1 knockout and wildtype mice. The rate of developmental synaptogenesis between the two genotypes was similar, but Fmr1 knockout mice exhibited levels of synaptic protein synthesis lower than those of wildtype mice. The role of FMRP in experience-dependent brain plasticity was also assessed. FMRP expression in the rat occipital cortex increases following exposure to a complex environment, but measures of synaptogenesis in Fmr1 knockout mice raised in this environment have been inconclusive. FMRP appears to be important for some, but not all forms of synaptic plasticity.","abstract_has_math":false,"creators":["Grossman, Aaron William"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":null,"degree_department":null,"school":null,"contributors":["Greenough, William T."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2006,"date_issued":"2006","date_published":"2006","updated_at":"2026-07-22T22:26:31Z","subjects":["Health Sciences, Medicine and Surgery"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(MiAaPQ)AAI3223601"],"render_values":[{"text":"(MiAaPQ)AAI3223601","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/87870","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Greenough, William T."]},{"key":"dc:creator","label":"Author","values":["Grossman, Aaron William"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2006","2015-09-28T21:56:35Z","10000-01-01"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Health Sciences, Medicine and Surgery"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/87870","(MiAaPQ)AAI3223601"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["In the next experiments, the ultrastructure of the visual cortex was examined in young Fmr1 knockout and wildtype mice. The rate of developmental synaptogenesis between the two genotypes was similar, but Fmr1 knockout mice exhibited levels of synaptic protein synthesis lower than those of wildtype mice. The role of FMRP in experience-dependent brain plasticity was also assessed. FMRP expression in the rat occipital cortex increases following exposure to a complex environment, but measures of synaptogenesis in Fmr1 knockout mice raised in this environment have been inconclusive. FMRP appears to be important for some, but not all forms of synaptic plasticity.","Made available in DSpace on 2015-09-28T21:56:35Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3223601.pdf: 4320638 bytes, checksum: 65aa9eab8969dd77c16f2a23b88f2658 (MD5) Previous issue date: 2006","Embargo set by: Seth Robbins for item 89151 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","136 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2006."]},{"key":"dc:title","label":"Title","values":["Synaptic Plasticity in the Cerebral Cortex of Fragile X Knockout Mice"]}]}],"canonical_facts":{"dc:contributor":["Greenough, William T."],"dc:creator":["Grossman, Aaron William"],"dc:date":["2006","2015-09-28T21:56:35Z","10000-01-01"],"dc:description":["In the next experiments, the ultrastructure of the visual cortex was examined in young Fmr1 knockout and wildtype mice. The rate of developmental synaptogenesis between the two genotypes was similar, but Fmr1 knockout mice exhibited levels of synaptic protein synthesis lower than those of wildtype mice. The role of FMRP in experience-dependent brain plasticity was also assessed. FMRP expression in the rat occipital cortex increases following exposure to a complex environment, but measures of synaptogenesis in Fmr1 knockout mice raised in this environment have been inconclusive. FMRP appears to be important for some, but not all forms of synaptic plasticity.","Made available in DSpace on 2015-09-28T21:56:35Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3223601.pdf: 4320638 bytes, checksum: 65aa9eab8969dd77c16f2a23b88f2658 (MD5) Previous issue date: 2006","Embargo set by: Seth Robbins for item 89151 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","136 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2006."],"dc:identifier":["http://hdl.handle.net/2142/87870","(MiAaPQ)AAI3223601"],"dc:language":["eng"],"dc:subject":["Health Sciences, Medicine and Surgery"],"dc:title":["Synaptic Plasticity in the Cerebral Cortex of Fragile X Knockout Mice"],"dc:type":["text"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:26:31Z"}