{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/87267"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/87267","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Integrated Entrainment of the Suprachiasmatic Clock by the Two Neurotransmitters of the Retinohypothalamic Tract, Glutamate and PACAP","abstract":"The functional interaction between PACAP and Glu was then investigated. PACAP blocked the phase advance normally induced by Glu at late night, while anti-PACAP reagents augmented the Glu-induced phase advance in the SCN slice as well as the light-induced phase advance in vivo. In the early night, PACAP enhanced Glu-induced delay while PACAP antagonists inhibited it. Anti-PACAP reagents also decreased the basal level of cAMP suggesting a tonic release of PACAP. Thus, through the interplay of an amino acid neurotransmitter and a large peptide neurotransmitter, the RHT signals fine-tune the phase of the SCN clock to the surrounding light/dark cycle. This finding provides insight as to how monotonic sensory signal is transformed into a modulated, adaptive behavioral response.","abstract_html":"The functional interaction between PACAP and Glu was then investigated. PACAP blocked the phase advance normally induced by Glu at late night, while anti-PACAP reagents augmented the Glu-induced phase advance in the SCN slice as well as the light-induced phase advance in vivo. In the early night, PACAP enhanced Glu-induced delay while PACAP antagonists inhibited it. Anti-PACAP reagents also decreased the basal level of cAMP suggesting a tonic release of PACAP. Thus, through the interplay of an amino acid neurotransmitter and a large peptide neurotransmitter, the RHT signals fine-tune the phase of the SCN clock to the surrounding light/dark cycle. This finding provides insight as to how monotonic sensory signal is transformed into a modulated, adaptive behavioral response.","abstract_has_math":false,"creators":["Dong, Chen"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Molecular and Integrative Physiology","degree_department":null,"school":null,"contributors":["Gillette, Martha U."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-28T15:50:17Z","date_published":"2015-09-28T15:50:17Z","updated_at":"2026-07-22T22:26:28Z","subjects":["Biology, Molecular"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(MiAaPQ)AAI9944816"],"render_values":[{"text":"(MiAaPQ)AAI9944816","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/87267","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Gillette, Martha U."]},{"key":"dc:creator","label":"Author","values":["Dong, Chen"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-09-28T15:50:17Z","10000-01-01","1999"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Molecular and Integrative Physiology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology, Molecular"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/87267","(MiAaPQ)AAI9944816"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The functional interaction between PACAP and Glu was then investigated. PACAP blocked the phase advance normally induced by Glu at late night, while anti-PACAP reagents augmented the Glu-induced phase advance in the SCN slice as well as the light-induced phase advance in vivo. In the early night, PACAP enhanced Glu-induced delay while PACAP antagonists inhibited it. Anti-PACAP reagents also decreased the basal level of cAMP suggesting a tonic release of PACAP. Thus, through the interplay of an amino acid neurotransmitter and a large peptide neurotransmitter, the RHT signals fine-tune the phase of the SCN clock to the surrounding light/dark cycle. This finding provides insight as to how monotonic sensory signal is transformed into a modulated, adaptive behavioral response.","Made available in DSpace on 2015-09-28T15:50:17Z (GMT). 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PACAP blocked the phase advance normally induced by Glu at late night, while anti-PACAP reagents augmented the Glu-induced phase advance in the SCN slice as well as the light-induced phase advance in vivo. In the early night, PACAP enhanced Glu-induced delay while PACAP antagonists inhibited it. Anti-PACAP reagents also decreased the basal level of cAMP suggesting a tonic release of PACAP. Thus, through the interplay of an amino acid neurotransmitter and a large peptide neurotransmitter, the RHT signals fine-tune the phase of the SCN clock to the surrounding light/dark cycle. This finding provides insight as to how monotonic sensory signal is transformed into a modulated, adaptive behavioral response.","Made available in DSpace on 2015-09-28T15:50:17Z (GMT). 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