{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/87259"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/87259","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Interactions of Thyroid Hormones, Nerve Growth Factor and Its Receptors in Development and Plasticity of the Rat Olfactory Bulb","abstract":"Hypothyroidism decreased levels of olfactory bulb NGF, while up-regulating NGF receptors, p75$\\sp{\\rm NTR}$ and trkA in the glomerular region. We propose that decreased bulbar NGF results in decreased trophic support for specific NGF responsive cells, leading to compensatory up-regulation of NGF receptors which compete for the limited supply of NGF. Thyroid hormone recovery restores levels of NGF and its receptors, leading to compensatory resumption of olfactory bulb tissue growth. Our findings present strong evidence for exceptional growth plasticity in the rat olfactory system, lasting beyond the normal development period. This plasticity may be mediated, in part, by regulatory and compensatory changes in the neurotrophin NGF and its receptors.","abstract_html":"Hypothyroidism decreased levels of olfactory bulb NGF, while up-regulating NGF receptors, p75$\\sp{\\rm NTR}$ and trkA in the glomerular region. We propose that decreased bulbar NGF results in decreased trophic support for specific NGF responsive cells, leading to compensatory up-regulation of NGF receptors which compete for the limited supply of NGF. Thyroid hormone recovery restores levels of NGF and its receptors, leading to compensatory resumption of olfactory bulb tissue growth. Our findings present strong evidence for exceptional growth plasticity in the rat olfactory system, lasting beyond the normal development period. This plasticity may be mediated, in part, by regulatory and compensatory changes in the neurotrophin NGF and its receptors.","abstract_has_math":true,"creators":["Sendera, Timothy John"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Molecular and Integrative Physiology","degree_department":null,"school":null,"contributors":["Esmail Meisami"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-28T15:50:16Z","date_published":"2015-09-28T15:50:16Z","updated_at":"2026-07-22T22:26:28Z","subjects":["Biology, Cell"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(MiAaPQ)AAI9812763"],"render_values":[{"text":"(MiAaPQ)AAI9812763","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/87259","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Esmail Meisami"]},{"key":"dc:creator","label":"Author","values":["Sendera, Timothy John"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-09-28T15:50:16Z","10000-01-01","1997"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Molecular and Integrative Physiology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology, Cell"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/87259","(MiAaPQ)AAI9812763"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Hypothyroidism decreased levels of olfactory bulb NGF, while up-regulating NGF receptors, p75$\\sp{\\rm NTR}$ and trkA in the glomerular region. We propose that decreased bulbar NGF results in decreased trophic support for specific NGF responsive cells, leading to compensatory up-regulation of NGF receptors which compete for the limited supply of NGF. Thyroid hormone recovery restores levels of NGF and its receptors, leading to compensatory resumption of olfactory bulb tissue growth. Our findings present strong evidence for exceptional growth plasticity in the rat olfactory system, lasting beyond the normal development period. This plasticity may be mediated, in part, by regulatory and compensatory changes in the neurotrophin NGF and its receptors.","Made available in DSpace on 2015-09-28T15:50:16Z (GMT). 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We propose that decreased bulbar NGF results in decreased trophic support for specific NGF responsive cells, leading to compensatory up-regulation of NGF receptors which compete for the limited supply of NGF. Thyroid hormone recovery restores levels of NGF and its receptors, leading to compensatory resumption of olfactory bulb tissue growth. Our findings present strong evidence for exceptional growth plasticity in the rat olfactory system, lasting beyond the normal development period. This plasticity may be mediated, in part, by regulatory and compensatory changes in the neurotrophin NGF and its receptors.","Made available in DSpace on 2015-09-28T15:50:16Z (GMT). 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