{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/87226"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/87226","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Cholinergic Regulation of the Mammalian Circadian System: Phase Shifting in Vivo and in Vitro in Wildtype and M(1) Knockout Mice Induced by Cholinergic Agonists","abstract":"These experiments demonstrate that ACh regulates the circadian clock via at least two different pathways. One induces phase advances throughout the night and is mediated via the M1AChR. The other causes a biphasic, light-like response and is not mediated via the M1AChR.","abstract_html":"These experiments demonstrate that ACh regulates the circadian clock via at least two different pathways. One induces phase advances throughout the night and is mediated via the M1AChR. The other causes a biphasic, light-like response and is not mediated via the M1AChR.","abstract_has_math":false,"creators":["Buchanan, Gordon Frank"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Molecular and Integrative Physiology","degree_department":null,"school":null,"contributors":["Gillette, Martha U."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-28T15:50:06Z","date_published":"2015-09-28T15:50:06Z","updated_at":"2026-07-22T22:26:28Z","subjects":["Biology, Neuroscience"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(MiAaPQ)AAI3086024"],"render_values":[{"text":"(MiAaPQ)AAI3086024","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/87226","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Gillette, Martha U."]},{"key":"dc:creator","label":"Author","values":["Buchanan, Gordon Frank"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-09-28T15:50:06Z","10000-01-01","2003"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Molecular and Integrative Physiology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology, Neuroscience"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/87226","(MiAaPQ)AAI3086024"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["These experiments demonstrate that ACh regulates the circadian clock via at least two different pathways. One induces phase advances throughout the night and is mediated via the M1AChR. The other causes a biphasic, light-like response and is not mediated via the M1AChR.","Made available in DSpace on 2015-09-28T15:50:06Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3086024.pdf: 7775423 bytes, checksum: a8ab92902cc2042369afef4db6af5a89 (MD5) Previous issue date: 2003","Embargo set by: Seth Robbins for item 88507 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","115 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2003."]},{"key":"dc:title","label":"Title","values":["Cholinergic Regulation of the Mammalian Circadian System: Phase Shifting in Vivo and in Vitro in Wildtype and M(1) Knockout Mice Induced by Cholinergic Agonists"]}]}],"canonical_facts":{"dc:contributor":["Gillette, Martha U."],"dc:creator":["Buchanan, Gordon Frank"],"dc:date":["2015-09-28T15:50:06Z","10000-01-01","2003"],"dc:description":["These experiments demonstrate that ACh regulates the circadian clock via at least two different pathways. One induces phase advances throughout the night and is mediated via the M1AChR. The other causes a biphasic, light-like response and is not mediated via the M1AChR.","Made available in DSpace on 2015-09-28T15:50:06Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3086024.pdf: 7775423 bytes, checksum: a8ab92902cc2042369afef4db6af5a89 (MD5) Previous issue date: 2003","Embargo set by: Seth Robbins for item 88507 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","115 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2003."],"dc:identifier":["http://hdl.handle.net/2142/87226","(MiAaPQ)AAI3086024"],"dc:language":["eng"],"dc:subject":["Biology, Neuroscience"],"dc:title":["Cholinergic Regulation of the Mammalian Circadian System: Phase Shifting in Vivo and in Vitro in Wildtype and M(1) Knockout Mice Induced by Cholinergic Agonists"],"dc:type":["text"],"thesis:degree_discipline":["Molecular and Integrative Physiology"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:26:28Z"}