{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/87218"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/87218","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Isolation and Characterization of Novel Estrogen Binding Proteins: Physiological Implications","abstract":"In summary, I have demonstrated the effect of estrogen and estrogen-like compounds on mitochondrial membrane-bound F0F1-ATPase and my efforts to isolate and identify cell membrane estrogen receptor have led me to discover a novel physiologically relevant estrogen binding protein: tubulin. Tubulin shows high affinity for estradiol and for testosterone, and these two steroid hormones modulate microtubule polymerization in an opposite manner. 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