{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/87216"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/87216","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Estrogen Receptors: Interaction With Estrogen Response Elements and Estrogen Receptor-Associated Proteins","abstract":"Since DNA-induced conformational changes in estrogen receptors affected recruitment of transcriptional coregulatory proteins, we examined differential recruitment of novel proteins. One novel protein was isolated and identified by protein sequencing as TAF-I beta, a protein previously implicated in acetylation, transcription and phosphorylation. TAF-I beta not only associates with ER in a cell environment, but also inhibits acetylation of histones and ER alpha in vitro and decreases ER alpha acetylation in vivo. Therefore, TAF-I beta may alter ER-mediated transcription by changing acetylation of ER or histones or both. Taken together, these data indicate that estrogen receptors associate with a variety of regulatory proteins and that interaction with these factors is affected both by an initial interaction with DNA and further modulated by receptor conformations induced by individual ERE sequences.","abstract_html":"Since DNA-induced conformational changes in estrogen receptors affected recruitment of transcriptional coregulatory proteins, we examined differential recruitment of novel proteins. One novel protein was isolated and identified by protein sequencing as TAF-I beta, a protein previously implicated in acetylation, transcription and phosphorylation. TAF-I beta not only associates with ER in a cell environment, but also inhibits acetylation of histones and ER alpha in vitro and decreases ER alpha acetylation in vivo. Therefore, TAF-I beta may alter ER-mediated transcription by changing acetylation of ER or histones or both. Taken together, these data indicate that estrogen receptors associate with a variety of regulatory proteins and that interaction with these factors is affected both by an initial interaction with DNA and further modulated by receptor conformations induced by individual ERE sequences.","abstract_has_math":false,"creators":["Loven, Margaret Anne"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Molecular and Integrative Physiology","degree_department":null,"school":null,"contributors":["Nardulli, Ann M."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-28T15:50:04Z","date_published":"2015-09-28T15:50:04Z","updated_at":"2026-07-22T22:26:28Z","subjects":["Biology, Molecular"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(MiAaPQ)AAI3044163"],"render_values":[{"text":"(MiAaPQ)AAI3044163","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/87216","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Nardulli, Ann M."]},{"key":"dc:creator","label":"Author","values":["Loven, Margaret Anne"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-09-28T15:50:04Z","10000-01-01","2002"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Molecular and Integrative Physiology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology, Molecular"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/87216","(MiAaPQ)AAI3044163"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Since DNA-induced conformational changes in estrogen receptors affected recruitment of transcriptional coregulatory proteins, we examined differential recruitment of novel proteins. One novel protein was isolated and identified by protein sequencing as TAF-I beta, a protein previously implicated in acetylation, transcription and phosphorylation. TAF-I beta not only associates with ER in a cell environment, but also inhibits acetylation of histones and ER alpha in vitro and decreases ER alpha acetylation in vivo. Therefore, TAF-I beta may alter ER-mediated transcription by changing acetylation of ER or histones or both. Taken together, these data indicate that estrogen receptors associate with a variety of regulatory proteins and that interaction with these factors is affected both by an initial interaction with DNA and further modulated by receptor conformations induced by individual ERE sequences.","Made available in DSpace on 2015-09-28T15:50:04Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3044163.pdf: 5284461 bytes, checksum: 6bbbd30feb3e26cf95bb7324e4987c5f (MD5) Previous issue date: 2002","Embargo set by: Seth Robbins for item 88497 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","110 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2002."]},{"key":"dc:title","label":"Title","values":["Estrogen Receptors: Interaction With Estrogen Response Elements and Estrogen Receptor-Associated Proteins"]}]}],"canonical_facts":{"dc:contributor":["Nardulli, Ann M."],"dc:creator":["Loven, Margaret Anne"],"dc:date":["2015-09-28T15:50:04Z","10000-01-01","2002"],"dc:description":["Since DNA-induced conformational changes in estrogen receptors affected recruitment of transcriptional coregulatory proteins, we examined differential recruitment of novel proteins. One novel protein was isolated and identified by protein sequencing as TAF-I beta, a protein previously implicated in acetylation, transcription and phosphorylation. TAF-I beta not only associates with ER in a cell environment, but also inhibits acetylation of histones and ER alpha in vitro and decreases ER alpha acetylation in vivo. Therefore, TAF-I beta may alter ER-mediated transcription by changing acetylation of ER or histones or both. Taken together, these data indicate that estrogen receptors associate with a variety of regulatory proteins and that interaction with these factors is affected both by an initial interaction with DNA and further modulated by receptor conformations induced by individual ERE sequences.","Made available in DSpace on 2015-09-28T15:50:04Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3044163.pdf: 5284461 bytes, checksum: 6bbbd30feb3e26cf95bb7324e4987c5f (MD5) Previous issue date: 2002","Embargo set by: Seth Robbins for item 88497 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","110 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2002."],"dc:identifier":["http://hdl.handle.net/2142/87216","(MiAaPQ)AAI3044163"],"dc:language":["eng"],"dc:subject":["Biology, Molecular"],"dc:title":["Estrogen Receptors: Interaction With Estrogen Response Elements and Estrogen Receptor-Associated Proteins"],"dc:type":["text"],"thesis:degree_discipline":["Molecular and Integrative Physiology"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:26:28Z"}