{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/87081"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/87081","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"The Design and Analysis of Pediatric Vaccine Formularies: Theory and Practice","abstract":"The first problem models a general childhood immunization schedule to design a vaccine formulary that minimizes the cost of fully immunizing a child. The second problem models a general childhood immunization schedule to design a vaccine formulary that safely immunizes a child against several infectious diseases by restricting or limiting extraimmunization (i.e., extra doses of vaccine). These problems are vitally important since the cost of vaccinating a child contributes to the underimmunization of children, and extraimmunization poses biological risks, amplifies philosophical concerns with vaccination, and creates an unnecessary economic burden on society. These models are rigorously analyzed and several algorithms---both exact and heuristic---are presented. Furthermore, a computational comparison of these algorithms is presented for the 2006 Recommended Childhood Immunization Schedule as well as several randomly generated childhood immunization schedules. The third problem combines the first two problems by modeling a general childhood immunization schedule to design a vaccine formulary that minimizes the cost of fully immunizing a child while restricting or limiting extraimmunization. The results reported here provide both fundamental insights to the operations research community as well as practical value for the public health community.","abstract_html":"The first problem models a general childhood immunization schedule to design a vaccine formulary that minimizes the cost of fully immunizing a child. The second problem models a general childhood immunization schedule to design a vaccine formulary that safely immunizes a child against several infectious diseases by restricting or limiting extraimmunization (i.e., extra doses of vaccine). These problems are vitally important since the cost of vaccinating a child contributes to the underimmunization of children, and extraimmunization poses biological risks, amplifies philosophical concerns with vaccination, and creates an unnecessary economic burden on society. These models are rigorously analyzed and several algorithms---both exact and heuristic---are presented. Furthermore, a computational comparison of these algorithms is presented for the 2006 Recommended Childhood Immunization Schedule as well as several randomly generated childhood immunization schedules. The third problem combines the first two problems by modeling a general childhood immunization schedule to design a vaccine formulary that minimizes the cost of fully immunizing a child while restricting or limiting extraimmunization. The results reported here provide both fundamental insights to the operations research community as well as practical value for the public health community.","abstract_has_math":false,"creators":["Hall, Shane Nikolaus"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Industrial Engineering","degree_department":null,"school":null,"contributors":["Jacobson, Sheldon H."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-28T15:37:19Z","date_published":"2015-09-28T15:37:19Z","updated_at":"2026-07-22T22:26:28Z","subjects":["Health Sciences, Public Health"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(MiAaPQ)AAI3242861"],"render_values":[{"text":"(MiAaPQ)AAI3242861","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/87081","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Jacobson, Sheldon H."]},{"key":"dc:creator","label":"Author","values":["Hall, Shane Nikolaus"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-09-28T15:37:19Z","10000-01-01","2006"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Industrial Engineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Health Sciences, Public Health"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/87081","(MiAaPQ)AAI3242861"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The first problem models a general childhood immunization schedule to design a vaccine formulary that minimizes the cost of fully immunizing a child. The second problem models a general childhood immunization schedule to design a vaccine formulary that safely immunizes a child against several infectious diseases by restricting or limiting extraimmunization (i.e., extra doses of vaccine). These problems are vitally important since the cost of vaccinating a child contributes to the underimmunization of children, and extraimmunization poses biological risks, amplifies philosophical concerns with vaccination, and creates an unnecessary economic burden on society. These models are rigorously analyzed and several algorithms---both exact and heuristic---are presented. Furthermore, a computational comparison of these algorithms is presented for the 2006 Recommended Childhood Immunization Schedule as well as several randomly generated childhood immunization schedules. The third problem combines the first two problems by modeling a general childhood immunization schedule to design a vaccine formulary that minimizes the cost of fully immunizing a child while restricting or limiting extraimmunization. The results reported here provide both fundamental insights to the operations research community as well as practical value for the public health community.","Made available in DSpace on 2015-09-28T15:37:19Z (GMT). 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The second problem models a general childhood immunization schedule to design a vaccine formulary that safely immunizes a child against several infectious diseases by restricting or limiting extraimmunization (i.e., extra doses of vaccine). These problems are vitally important since the cost of vaccinating a child contributes to the underimmunization of children, and extraimmunization poses biological risks, amplifies philosophical concerns with vaccination, and creates an unnecessary economic burden on society. These models are rigorously analyzed and several algorithms---both exact and heuristic---are presented. Furthermore, a computational comparison of these algorithms is presented for the 2006 Recommended Childhood Immunization Schedule as well as several randomly generated childhood immunization schedules. The third problem combines the first two problems by modeling a general childhood immunization schedule to design a vaccine formulary that minimizes the cost of fully immunizing a child while restricting or limiting extraimmunization. The results reported here provide both fundamental insights to the operations research community as well as practical value for the public health community.","Made available in DSpace on 2015-09-28T15:37:19Z (GMT). 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