{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/86673"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/86673","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Cloning, Phenotypic, and Experimental Analysis of Pat-4: The Caenorhabditis Elegans Homologue of Integrin -Linked Kinase","abstract":"\"The third chapter describes experimental analysis of pat-4 during the morphogenesis of the excretory canal cell. By completely removing pat-4 expression from the excretory cell, I demonstrate that pat-4 is essential for the active outgrowth and complete extension of the excretory canal processes during embryogenesis and early larval development. Interestingly, \"\"kinase-dead\"\" and PH domain-disrupted forms of PAT-4/ILK support initial canal outgrowth. However, these canals frequently fail to fully extend during active canal outgrowth resulting in shortened, misshaped mature canals. These results identify a new developmental function for PAT-4/ILK in C. elegans and directly establish a role for ILK during the dynamic process of cellular morphogenesis in vivo .\"","abstract_html":""The third chapter describes experimental analysis of pat-4 during the morphogenesis of the excretory canal cell. By completely removing pat-4 expression from the excretory cell, I demonstrate that pat-4 is essential for the active outgrowth and complete extension of the excretory canal processes during embryogenesis and early larval development. Interestingly, ""kinase-dead"" and PH domain-disrupted forms of PAT-4/ILK support initial canal outgrowth. However, these canals frequently fail to fully extend during active canal outgrowth resulting in shortened, misshaped mature canals. These results identify a new developmental function for PAT-4/ILK in C. elegans and directly establish a role for ILK during the dynamic process of cellular morphogenesis in vivo ."","abstract_has_math":false,"creators":["Mackinnon, Alexander Craig, Jr"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Microbiology","degree_department":null,"school":null,"contributors":["Benjamin D. Williams"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-28T15:17:20Z","date_published":"2015-09-28T15:17:20Z","updated_at":"2026-07-22T22:26:27Z","subjects":["Biology, Cell"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(MiAaPQ)AAI3153370"],"render_values":[{"text":"(MiAaPQ)AAI3153370","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/86673","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Benjamin D. 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Williams"],"dc:creator":["Mackinnon, Alexander Craig, Jr"],"dc:date":["2015-09-28T15:17:20Z","10000-01-01","2004"],"dc:description":["\"The third chapter describes experimental analysis of pat-4 during the morphogenesis of the excretory canal cell. By completely removing pat-4 expression from the excretory cell, I demonstrate that pat-4 is essential for the active outgrowth and complete extension of the excretory canal processes during embryogenesis and early larval development. Interestingly, \"\"kinase-dead\"\" and PH domain-disrupted forms of PAT-4/ILK support initial canal outgrowth. However, these canals frequently fail to fully extend during active canal outgrowth resulting in shortened, misshaped mature canals. These results identify a new developmental function for PAT-4/ILK in C. elegans and directly establish a role for ILK during the dynamic process of cellular morphogenesis in vivo .\"","Made available in DSpace on 2015-09-28T15:17:20Z (GMT). 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