{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/86383"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/86383","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Aging Delays and Exercise Accelerates Wound Healing and Decreases Inflammation in Old Mice","abstract":"This study's purpose was to determine the effect of exercise on wound healing and inflammation in young (three months) and old (18-months) female Balb/cByJ mice. Mice were assigned to either exercise (EX) or sedentary control (CON) group. EX mice were run on a motorized treadmill at a moderate intensity for 30 minutes/day for eight days, three days before wounding, and five days afterwards. Mice were given four full thickness dermal wounds using a 3.5mm punch biopsy instrument and wounds were photographed for 10 days. After the old mice fully healed (approximately 3 months), they were wounded again in different locations and wounds with surrounding tissue were harvested at one, three, or five days after wounding. Harvested wound tissue was analyzed with the Bio-Plex(TM) cytokine assay for interleukin-1 (IL-1beta), interleukin-6 (IL-6), keratinocyte chemoattractant (KC), monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factor alpha (TNF-alpha). No significant differences in wound size were found as a result of exercise in young mice. However, exercise significantly decreased wound size in old mice when compared to sedentary control mice (F(1,38) = 6.33, p = .016). Levels of some proinflammatory cytokines and chemokines in wound tissue of exercised mice were significantly lower than control mice, including TNF-alpha, KC, and MCP-1. No group differences were found in IL-1beta or IL-6. These data suggest that exercise accelerates the wound healing process in old mice, which is delayed, but not young mice, which display quick healing. In addition, moderate exercise-associated decreases in levels of some inflammatory cytokines and chemokines in wound tissue were associated with faster healing.","abstract_html":"This study's purpose was to determine the effect of exercise on wound healing and inflammation in young (three months) and old (18-months) female Balb/cByJ mice. Mice were assigned to either exercise (EX) or sedentary control (CON) group. EX mice were run on a motorized treadmill at a moderate intensity for 30 minutes/day for eight days, three days before wounding, and five days afterwards. Mice were given four full thickness dermal wounds using a 3.5mm punch biopsy instrument and wounds were photographed for 10 days. After the old mice fully healed (approximately 3 months), they were wounded again in different locations and wounds with surrounding tissue were harvested at one, three, or five days after wounding. Harvested wound tissue was analyzed with the Bio-Plex(TM) cytokine assay for interleukin-1 (IL-1beta), interleukin-6 (IL-6), keratinocyte chemoattractant (KC), monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factor alpha (TNF-alpha). No significant differences in wound size were found as a result of exercise in young mice. However, exercise significantly decreased wound size in old mice when compared to sedentary control mice (F(1,38) = 6.33, p = .016). Levels of some proinflammatory cytokines and chemokines in wound tissue of exercised mice were significantly lower than control mice, including TNF-alpha, KC, and MCP-1. No group differences were found in IL-1beta or IL-6. These data suggest that exercise accelerates the wound healing process in old mice, which is delayed, but not young mice, which display quick healing. In addition, moderate exercise-associated decreases in levels of some inflammatory cytokines and chemokines in wound tissue were associated with faster healing.","abstract_has_math":false,"creators":["Keylock, Kerry Todd"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Kinesiology and Community Health","degree_department":null,"school":null,"contributors":["Jeff Woods"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-28T15:04:24Z","date_published":"2015-09-28T15:04:24Z","updated_at":"2026-07-22T22:26:27Z","subjects":["Health Sciences, Recreation"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(MiAaPQ)AAI3269939"],"render_values":[{"text":"(MiAaPQ)AAI3269939","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/86383","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Jeff Woods"]},{"key":"dc:creator","label":"Author","values":["Keylock, Kerry Todd"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-09-28T15:04:24Z","10000-01-01","2007"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Kinesiology and Community Health"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Health Sciences, Recreation"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/86383","(MiAaPQ)AAI3269939"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["This study's purpose was to determine the effect of exercise on wound healing and inflammation in young (three months) and old (18-months) female Balb/cByJ mice. Mice were assigned to either exercise (EX) or sedentary control (CON) group. EX mice were run on a motorized treadmill at a moderate intensity for 30 minutes/day for eight days, three days before wounding, and five days afterwards. Mice were given four full thickness dermal wounds using a 3.5mm punch biopsy instrument and wounds were photographed for 10 days. After the old mice fully healed (approximately 3 months), they were wounded again in different locations and wounds with surrounding tissue were harvested at one, three, or five days after wounding. Harvested wound tissue was analyzed with the Bio-Plex(TM) cytokine assay for interleukin-1 (IL-1beta), interleukin-6 (IL-6), keratinocyte chemoattractant (KC), monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factor alpha (TNF-alpha). No significant differences in wound size were found as a result of exercise in young mice. However, exercise significantly decreased wound size in old mice when compared to sedentary control mice (F(1,38) = 6.33, p = .016). Levels of some proinflammatory cytokines and chemokines in wound tissue of exercised mice were significantly lower than control mice, including TNF-alpha, KC, and MCP-1. No group differences were found in IL-1beta or IL-6. These data suggest that exercise accelerates the wound healing process in old mice, which is delayed, but not young mice, which display quick healing. In addition, moderate exercise-associated decreases in levels of some inflammatory cytokines and chemokines in wound tissue were associated with faster healing.","Made available in DSpace on 2015-09-28T15:04:24Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3269939.pdf: 1961703 bytes, checksum: a1eee4a8a37d2fdef72cc2064b98f6e1 (MD5) Previous issue date: 2007","Embargo set by: Seth Robbins for item 87664 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","73 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2007."]},{"key":"dc:title","label":"Title","values":["Aging Delays and Exercise Accelerates Wound Healing and Decreases Inflammation in Old Mice"]}]}],"canonical_facts":{"dc:contributor":["Jeff Woods"],"dc:creator":["Keylock, Kerry Todd"],"dc:date":["2015-09-28T15:04:24Z","10000-01-01","2007"],"dc:description":["This study's purpose was to determine the effect of exercise on wound healing and inflammation in young (three months) and old (18-months) female Balb/cByJ mice. Mice were assigned to either exercise (EX) or sedentary control (CON) group. EX mice were run on a motorized treadmill at a moderate intensity for 30 minutes/day for eight days, three days before wounding, and five days afterwards. Mice were given four full thickness dermal wounds using a 3.5mm punch biopsy instrument and wounds were photographed for 10 days. After the old mice fully healed (approximately 3 months), they were wounded again in different locations and wounds with surrounding tissue were harvested at one, three, or five days after wounding. Harvested wound tissue was analyzed with the Bio-Plex(TM) cytokine assay for interleukin-1 (IL-1beta), interleukin-6 (IL-6), keratinocyte chemoattractant (KC), monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factor alpha (TNF-alpha). No significant differences in wound size were found as a result of exercise in young mice. However, exercise significantly decreased wound size in old mice when compared to sedentary control mice (F(1,38) = 6.33, p = .016). Levels of some proinflammatory cytokines and chemokines in wound tissue of exercised mice were significantly lower than control mice, including TNF-alpha, KC, and MCP-1. No group differences were found in IL-1beta or IL-6. These data suggest that exercise accelerates the wound healing process in old mice, which is delayed, but not young mice, which display quick healing. In addition, moderate exercise-associated decreases in levels of some inflammatory cytokines and chemokines in wound tissue were associated with faster healing.","Made available in DSpace on 2015-09-28T15:04:24Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3269939.pdf: 1961703 bytes, checksum: a1eee4a8a37d2fdef72cc2064b98f6e1 (MD5) Previous issue date: 2007","Embargo set by: Seth Robbins for item 87664 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","73 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2007."],"dc:identifier":["http://hdl.handle.net/2142/86383","(MiAaPQ)AAI3269939"],"dc:language":["eng"],"dc:subject":["Health Sciences, Recreation"],"dc:title":["Aging Delays and Exercise Accelerates Wound Healing and Decreases Inflammation in Old Mice"],"dc:type":["text"],"thesis:degree_discipline":["Kinesiology and Community Health"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:26:27Z"}