{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/86382"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/86382","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Effects of Exercise on Immune Function in Young, Adult, and Aged Mice: Increased Survival and a Decrease in Inflammation","abstract":"We have previously shown that moderate exercise for 4 days during a mounting immune response significantly increases survival during influenza virus (A/PR/8/34) infection in mice. We hypothesized that this brief duration of exercise resulted in a decreased level of lung histopathology while altering the immune response from a Th1 (inflammatory) to a Th2 (Anti-inflammatory) response. Adult male Balb/cByJ mice (5-6mo) were inflected with 50uL of A/PR/8/34 influenza virus (40HAU) intranasally under light anesthesia (Isoflurane) and randomized to either an exercise (EX) or sedentary (SED) group. EX mice performed 20-3min of moderate exercise (8-12m/min) on a motorized treadmill 4hr post-infection and then exercised similarly for 4 consecutive days. SED mice were exposed to similar environmental conditions but did not exercise. Mice from both EX and SED groups were sacrificed 1, 3, or 5 days post-infection lungs, mediastinal lymph nodes and spleens were harvested. We found a profound reduction in IFN-gamma in lungs of EX mice when compared to SED mice 3 and 5 days post-infection. There was also a reduction in viral gene mRNA expression, although not at the level of statistical significance (p=0.241). While there were no statistically significant differences in percentage or absolute number of CED8+ cells in the lungs of infected mice, EX mice had significantly fewer cells compared with SED mice 5 days post-infection. Interestingly, we found no observable difference in lung histopathology between groups. These data suggest that moderate exercise shifts the immune response from a Th1 to a Th2 profile in mice infected with influenza virus. This exercise-induced shift in immune response may be responsible for improved survival after influenza virus infection.","abstract_html":"We have previously shown that moderate exercise for 4 days during a mounting immune response significantly increases survival during influenza virus (A/PR/8/34) infection in mice. We hypothesized that this brief duration of exercise resulted in a decreased level of lung histopathology while altering the immune response from a Th1 (inflammatory) to a Th2 (Anti-inflammatory) response. Adult male Balb/cByJ mice (5-6mo) were inflected with 50uL of A/PR/8/34 influenza virus (40HAU) intranasally under light anesthesia (Isoflurane) and randomized to either an exercise (EX) or sedentary (SED) group. EX mice performed 20-3min of moderate exercise (8-12m/min) on a motorized treadmill 4hr post-infection and then exercised similarly for 4 consecutive days. SED mice were exposed to similar environmental conditions but did not exercise. Mice from both EX and SED groups were sacrificed 1, 3, or 5 days post-infection lungs, mediastinal lymph nodes and spleens were harvested. We found a profound reduction in IFN-gamma in lungs of EX mice when compared to SED mice 3 and 5 days post-infection. There was also a reduction in viral gene mRNA expression, although not at the level of statistical significance (p=0.241). While there were no statistically significant differences in percentage or absolute number of CED8+ cells in the lungs of infected mice, EX mice had significantly fewer cells compared with SED mice 5 days post-infection. Interestingly, we found no observable difference in lung histopathology between groups. These data suggest that moderate exercise shifts the immune response from a Th1 to a Th2 profile in mice infected with influenza virus. This exercise-induced shift in immune response may be responsible for improved survival after influenza virus infection.","abstract_has_math":false,"creators":["Lowder, Thomas W."],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Kinesiology and Community Health","degree_department":null,"school":null,"contributors":["Jeff Woods"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2006,"date_issued":"2006","date_published":"2006","updated_at":"2026-07-22T22:26:27Z","subjects":["Biology, Physiology"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(MiAaPQ)AAI3250283"],"render_values":[{"text":"(MiAaPQ)AAI3250283","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/86382","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Jeff Woods"]},{"key":"dc:creator","label":"Author","values":["Lowder, Thomas W."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2006","10000-01-01","2015-09-28T15:04:24Z"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Kinesiology and Community Health"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology, Physiology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/86382","(MiAaPQ)AAI3250283"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["We have previously shown that moderate exercise for 4 days during a mounting immune response significantly increases survival during influenza virus (A/PR/8/34) infection in mice. We hypothesized that this brief duration of exercise resulted in a decreased level of lung histopathology while altering the immune response from a Th1 (inflammatory) to a Th2 (Anti-inflammatory) response. Adult male Balb/cByJ mice (5-6mo) were inflected with 50uL of A/PR/8/34 influenza virus (40HAU) intranasally under light anesthesia (Isoflurane) and randomized to either an exercise (EX) or sedentary (SED) group. EX mice performed 20-3min of moderate exercise (8-12m/min) on a motorized treadmill 4hr post-infection and then exercised similarly for 4 consecutive days. SED mice were exposed to similar environmental conditions but did not exercise. Mice from both EX and SED groups were sacrificed 1, 3, or 5 days post-infection lungs, mediastinal lymph nodes and spleens were harvested. We found a profound reduction in IFN-gamma in lungs of EX mice when compared to SED mice 3 and 5 days post-infection. There was also a reduction in viral gene mRNA expression, although not at the level of statistical significance (p=0.241). While there were no statistically significant differences in percentage or absolute number of CED8+ cells in the lungs of infected mice, EX mice had significantly fewer cells compared with SED mice 5 days post-infection. Interestingly, we found no observable difference in lung histopathology between groups. These data suggest that moderate exercise shifts the immune response from a Th1 to a Th2 profile in mice infected with influenza virus. This exercise-induced shift in immune response may be responsible for improved survival after influenza virus infection.","Made available in DSpace on 2015-09-28T15:04:24Z (GMT). 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We hypothesized that this brief duration of exercise resulted in a decreased level of lung histopathology while altering the immune response from a Th1 (inflammatory) to a Th2 (Anti-inflammatory) response. Adult male Balb/cByJ mice (5-6mo) were inflected with 50uL of A/PR/8/34 influenza virus (40HAU) intranasally under light anesthesia (Isoflurane) and randomized to either an exercise (EX) or sedentary (SED) group. EX mice performed 20-3min of moderate exercise (8-12m/min) on a motorized treadmill 4hr post-infection and then exercised similarly for 4 consecutive days. SED mice were exposed to similar environmental conditions but did not exercise. Mice from both EX and SED groups were sacrificed 1, 3, or 5 days post-infection lungs, mediastinal lymph nodes and spleens were harvested. We found a profound reduction in IFN-gamma in lungs of EX mice when compared to SED mice 3 and 5 days post-infection. There was also a reduction in viral gene mRNA expression, although not at the level of statistical significance (p=0.241). While there were no statistically significant differences in percentage or absolute number of CED8+ cells in the lungs of infected mice, EX mice had significantly fewer cells compared with SED mice 5 days post-infection. Interestingly, we found no observable difference in lung histopathology between groups. These data suggest that moderate exercise shifts the immune response from a Th1 to a Th2 profile in mice infected with influenza virus. This exercise-induced shift in immune response may be responsible for improved survival after influenza virus infection.","Made available in DSpace on 2015-09-28T15:04:24Z (GMT). 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