Regional Fat Distribution, Physical Activity and Hormonal Factors in Adults With Type 2 Diabetes
type: CreativeWork
description: This study evaluated the association between central fat (CF) and both plasma hormones and physical activity (PA) in 17 men and 23 women (mean age 62 years, body mass index 31 kg/m2) with type 2 diabetes. Dual energy X-ray absorptiometry was used to assess central abdominal fat (CAF), abdominal fat (AF), and trunk fat (TF). Testosterone, free testosterone (FT), estradiol and insulin-like growth factor I (IGF-I) were assessed by radioimmunoassay. Sex-hormone binding globulin (SHBG), and androgeneicity index (AI) were calculated from testosterone and FT. Leisure, occupational, household, non-leisure and total physical activity (TPA) at time1 (15--22 years of age), time2 (23--34 years), time3 (35--50 years), and time4 (past 12 months) were assessed by a historical PA questionnaire. Results showed that (a) participants had lower values of testosterone, FT, and IGF-I, and higher values of SHBG than healthy individuals; (b) in men, CAF and TF were negatively associated with occupational, household, non-leisure, and TPA (r = -0.47 to -0.55). PA at time3 and time4 were negatively associated with TF (r = -0.51 and -0.54, respectively). Total and household activities at time3 were negatively associated with waist circumference (r = -0.53 and -0.57, respectively); (c) in women, CAF and TF were positively associated with household (r = 0.54 and 0.56) and non-leisure (r = 0.41 and 0.42, respectively) activity. AF was positively associated with household (r = 0.42) but negatively associated with leisure activity (r = -0.42); (d) in women, estradiol was negatively associated with AF (r = -0.66). In a subsample of women on estrogen replacement (n = 10), SHBG and estradiol were negatively associated with CAF (r = -0.75 and -0.65) and TF (r = -0.69 and -0.65, respectively). Al was positively associated with CAF (r = 0.69) and TF ( r = 0.68). In conclusion, PA and CF are negatively associated in older men with type2 diabetes. The positive associations in women were attributed to measu…
abstract: This study evaluated the association between central fat (CF) and both plasma hormones and physical activity (PA) in 17 men and 23 women (mean age 62 years, body mass index 31 kg/m2) with type 2 diabetes. Dual energy X-ray absorptiometry was used to assess central abdominal fat (CAF), abdominal fat (AF), and trunk fat (TF). Testosterone, free testosterone (FT), estradiol and insulin-like growth factor I (IGF-I) were assessed by radioimmunoassay. Sex-hormone binding globulin (SHBG), and androgeneicity index (AI) were calculated from testosterone and FT. Leisure, occupational, household, non-leisure and total physical activity (TPA) at time1 (15--22 years of age), time2 (23--34 years), time3 (35--50 years), and time4 (past 12 months) were assessed by a historical PA questionnaire. Results showed that (a) participants had lower values of testosterone, FT, and IGF-I, and higher values of SHBG than healthy individuals; (b) in men, CAF and TF were negatively associated with occupational, household, non-leisure, and TPA (r = -0.47 to -0.55). PA at time3 and time4 were negatively associated with TF (r = -0.51 and -0.54, respectively). Total and household activities at time3 were negatively associated with waist circumference (r = -0.53 and -0.57, respectively); (c) in women, CAF and TF were positively associated with household (r = 0.54 and 0.56) and non-leisure (r = 0.41 and 0.42, respectively) activity. AF was positively associated with household (r = 0.42) but negatively associated with leisure activity (r = -0.42); (d) in women, estradiol was negatively associated with AF (r = -0.66). In a subsample of women on estrogen replacement (n = 10), SHBG and estradiol were negatively associated with CAF (r = -0.75 and -0.65) and TF (r = -0.69 and -0.65, respectively). Al was positively associated with CAF (r = 0.69) and TF ( r = 0.68). In conclusion, PA and CF are negatively associated in older men with type2 diabetes. The positive associations in women were attributed to measu…
author: Pascale, Angelo
language: eng
keywords: Health Sciences, Public Health
date published: 2015-09-28T15:04:18Z
date modified: 2026-07-22T22:26:27Z
provider: University of Illinois - Urbana-Champaign
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of Illinois at Urbana-Champaign

PropertyValue
property ID: Handle
value: http://hdl.handle.net/2142/86365