{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/86304"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/86304","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Requirement of Baboon/dsmad2-Mediated Tgf-Beta/activin Signaling for Post-Mitotic Neuronal Development in the Drosophila Brain","abstract":"The intermingling of larval functional neurons with adult-specific neurons during metamorphosis contributes to the development of the Drosophila adult brain. This study provides evidence for cell-autonomous involvement of widespread Baboon/dSmad2-mediated TGF-beta/Activin signaling in various neuronal developmental processes prior to the prepupal ecdysone peak. Interestingly, this stage-specific Babo/dSmad2 signaling appears to accelerate maturation and morphogenesis of post-mitotic neurons throughout the entire nervous system. Loss of Babo/dSmad2 drastically delays adult-specific neurons' initial morphogenesis, while Babo/dSmad2 acts to assure timely expression of EcR-B1 in larval functional neurons. This study, thus, suggests that TGF-beta signaling prior to metamorphosis may be widely required to prepare neurons for the rapidly changing environment present during metamorphosis. Given that many vertebrate TGF-beta signaling molecules are dynamically present in the postnatal brain, it is possible that similar mechanisms may help modulate neural circuitry in higher organisms during periods of extensive morphogenesis.","abstract_html":"The intermingling of larval functional neurons with adult-specific neurons during metamorphosis contributes to the development of the Drosophila adult brain. This study provides evidence for cell-autonomous involvement of widespread Baboon/dSmad2-mediated TGF-beta/Activin signaling in various neuronal developmental processes prior to the prepupal ecdysone peak. Interestingly, this stage-specific Babo/dSmad2 signaling appears to accelerate maturation and morphogenesis of post-mitotic neurons throughout the entire nervous system. Loss of Babo/dSmad2 drastically delays adult-specific neurons' initial morphogenesis, while Babo/dSmad2 acts to assure timely expression of EcR-B1 in larval functional neurons. This study, thus, suggests that TGF-beta signaling prior to metamorphosis may be widely required to prepare neurons for the rapidly changing environment present during metamorphosis. Given that many vertebrate TGF-beta signaling molecules are dynamically present in the postnatal brain, it is possible that similar mechanisms may help modulate neural circuitry in higher organisms during periods of extensive morphogenesis.","abstract_has_math":false,"creators":["Zheng, Xiaoyan"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Cell and Developmental Biology","degree_department":null,"school":null,"contributors":["Tzumin Lee"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-28T15:03:16Z","date_published":"2015-09-28T15:03:16Z","updated_at":"2026-07-22T22:26:27Z","subjects":["Biology, Genetics"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(MiAaPQ)AAI3202199"],"render_values":[{"text":"(MiAaPQ)AAI3202199","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/86304","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Tzumin Lee"]},{"key":"dc:creator","label":"Author","values":["Zheng, Xiaoyan"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-09-28T15:03:16Z","10000-01-01","2005"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Cell and Developmental Biology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology, Genetics"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/86304","(MiAaPQ)AAI3202199"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The intermingling of larval functional neurons with adult-specific neurons during metamorphosis contributes to the development of the Drosophila adult brain. 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