Steroid Hormone Regulation of Implantation
type: CreativeWork
description: Steroid hormones Estrogen (E) and Progesterone (P) coordinate to regulate the process of embryo implantation, the process by which embryo attaches to the uterine epithelium. The uterus in response to the implanting embryo undergoes various changes to help create a suitable environment for the implanting embryo. E and P regulate this process in the uterus, by upregulating various downstream target genes. To date very little is known about the downstream targets of E and P and how these effect changes in the uterus to culminate in successful implantation. In order to identify these targets we have used microarray analysis. CCAAT enhancer binding protein beta (C/EBP beta) was identified as target of both E and P that helps in the uterine epithelial proliferation followed by participation in both uterine stromal cell proliferation and differentiation. These results are discussed in chapter I of the thesis. Ovarian E surge is necessary for implantation, which occurs in mice on day 4 evening. The current notion is that E plays minimal role in the process of decidualization. Our studies show prominent expression of aromatase, the key enzyme involved in E synthesis, in the pregnant uterus during decidual phase of gestation. Studies in chapter II of the thesis describe the spatiotemporal expression pattern of this enzyme and the critical role of aromatase in the process of decidualization. Lipid droplets in various organs are indicative of steroidogenic potential. Previous studies have shown occurrence of lipid droplets in the uterus during pregnancy. In chapter III we describe how P mediates the assembly of these lipid droplets at the stromal epithelial border and E surge that occurs on day four afternoon helps in the dispersal of these droplets, by regulating lipid binding proteins such as tail interacting protein of 47 kilo Daltons (TIP 47). The lipid droplets along with the associated proteins are recently termed as adiposomes. While the exact function of these adiposome…
abstract: Steroid hormones Estrogen (E) and Progesterone (P) coordinate to regulate the process of embryo implantation, the process by which embryo attaches to the uterine epithelium. The uterus in response to the implanting embryo undergoes various changes to help create a suitable environment for the implanting embryo. E and P regulate this process in the uterus, by upregulating various downstream target genes. To date very little is known about the downstream targets of E and P and how these effect changes in the uterus to culminate in successful implantation. In order to identify these targets we have used microarray analysis. CCAAT enhancer binding protein beta (C/EBP beta) was identified as target of both E and P that helps in the uterine epithelial proliferation followed by participation in both uterine stromal cell proliferation and differentiation. These results are discussed in chapter I of the thesis. Ovarian E surge is necessary for implantation, which occurs in mice on day 4 evening. The current notion is that E plays minimal role in the process of decidualization. Our studies show prominent expression of aromatase, the key enzyme involved in E synthesis, in the pregnant uterus during decidual phase of gestation. Studies in chapter II of the thesis describe the spatiotemporal expression pattern of this enzyme and the critical role of aromatase in the process of decidualization. Lipid droplets in various organs are indicative of steroidogenic potential. Previous studies have shown occurrence of lipid droplets in the uterus during pregnancy. In chapter III we describe how P mediates the assembly of these lipid droplets at the stromal epithelial border and E surge that occurs on day four afternoon helps in the dispersal of these droplets, by regulating lipid binding proteins such as tail interacting protein of 47 kilo Daltons (TIP 47). The lipid droplets along with the associated proteins are recently termed as adiposomes. While the exact function of these adiposome…
author: Mantena, Srinivasa R.
language: eng
keywords: Biology, Veterinary Science
date published: 2015-09-25T22:42:33Z
date modified: 2026-07-22T22:26:25Z
provider: University of Illinois - Urbana-Champaign
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of Illinois at Urbana-Champaign

PropertyValue
property ID: Handle
value: http://hdl.handle.net/2142/85371