{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/84967"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/84967","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Impact of Dietary Carbohydrate and Protein Levels on Carbohydrate Metabolism","abstract":"The third objective evaluated differential tissue responses in gene expression and metabolic signaling in liver, muscle, and adipose tissue associated with diets containing 58%, 40%, or 25% of energy as CARB. These diets represent high (HC), moderate (MC), and low (LC) CARB amounts within the acceptable macronutrient distribution range for the DRI. This study was designed to identify the range of metabolic adaptations required to maintain glucose homeostasis across the recommended dietary range of CARB. While plasma glucose was maintained within normal range, as dietary CARB increased in the diet, there was a progression of saturation of hepatic glucose regulations including increased post-prandial glycogen, decreased GNG capacity (decreased expression of PEPCK) with increased lipogenic activity (increased FAS expression) in addition to the corresponding SREBP1c expression in liver. This increase in dietary CARB then exceeded skeletal muscle utilization of glucose, becoming reliant on adipose uptake of glucose: increased glucose uptake into muscle in addition to patterns observed in insulin signaling elements and FAS expression in adipose tissue. Though optimal macronutrient content remains unknown, increases in physiologic ranges of CARB in the diet produce huge shifts in metabolism while maintaining glucose homeostasis. (Abstract shortened by UMI.).","abstract_html":"The third objective evaluated differential tissue responses in gene expression and metabolic signaling in liver, muscle, and adipose tissue associated with diets containing 58%, 40%, or 25% of energy as CARB. These diets represent high (HC), moderate (MC), and low (LC) CARB amounts within the acceptable macronutrient distribution range for the DRI. This study was designed to identify the range of metabolic adaptations required to maintain glucose homeostasis across the recommended dietary range of CARB. While plasma glucose was maintained within normal range, as dietary CARB increased in the diet, there was a progression of saturation of hepatic glucose regulations including increased post-prandial glycogen, decreased GNG capacity (decreased expression of PEPCK) with increased lipogenic activity (increased FAS expression) in addition to the corresponding SREBP1c expression in liver. This increase in dietary CARB then exceeded skeletal muscle utilization of glucose, becoming reliant on adipose uptake of glucose: increased glucose uptake into muscle in addition to patterns observed in insulin signaling elements and FAS expression in adipose tissue. Though optimal macronutrient content remains unknown, increases in physiologic ranges of CARB in the diet produce huge shifts in metabolism while maintaining glucose homeostasis. (Abstract shortened by UMI.).","abstract_has_math":false,"creators":["Lasker, Denise Ann"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Nutritional Sciences","degree_department":null,"school":null,"contributors":["Evans, Ellen M."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-25T22:31:09Z","date_published":"2015-09-25T22:31:09Z","updated_at":"2026-07-22T22:26:24Z","subjects":["Biology, Physiology"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(MiAaPQ)AAI3392111"],"render_values":[{"text":"(MiAaPQ)AAI3392111","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/84967","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Evans, Ellen M."]},{"key":"dc:creator","label":"Author","values":["Lasker, Denise Ann"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-09-25T22:31:09Z","10000-01-01","2009"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Nutritional Sciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology, Physiology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/84967","(MiAaPQ)AAI3392111"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The third objective evaluated differential tissue responses in gene expression and metabolic signaling in liver, muscle, and adipose tissue associated with diets containing 58%, 40%, or 25% of energy as CARB. These diets represent high (HC), moderate (MC), and low (LC) CARB amounts within the acceptable macronutrient distribution range for the DRI. This study was designed to identify the range of metabolic adaptations required to maintain glucose homeostasis across the recommended dietary range of CARB. While plasma glucose was maintained within normal range, as dietary CARB increased in the diet, there was a progression of saturation of hepatic glucose regulations including increased post-prandial glycogen, decreased GNG capacity (decreased expression of PEPCK) with increased lipogenic activity (increased FAS expression) in addition to the corresponding SREBP1c expression in liver. This increase in dietary CARB then exceeded skeletal muscle utilization of glucose, becoming reliant on adipose uptake of glucose: increased glucose uptake into muscle in addition to patterns observed in insulin signaling elements and FAS expression in adipose tissue. Though optimal macronutrient content remains unknown, increases in physiologic ranges of CARB in the diet produce huge shifts in metabolism while maintaining glucose homeostasis. (Abstract shortened by UMI.).","Made available in DSpace on 2015-09-25T22:31:09Z (GMT). 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These diets represent high (HC), moderate (MC), and low (LC) CARB amounts within the acceptable macronutrient distribution range for the DRI. This study was designed to identify the range of metabolic adaptations required to maintain glucose homeostasis across the recommended dietary range of CARB. While plasma glucose was maintained within normal range, as dietary CARB increased in the diet, there was a progression of saturation of hepatic glucose regulations including increased post-prandial glycogen, decreased GNG capacity (decreased expression of PEPCK) with increased lipogenic activity (increased FAS expression) in addition to the corresponding SREBP1c expression in liver. This increase in dietary CARB then exceeded skeletal muscle utilization of glucose, becoming reliant on adipose uptake of glucose: increased glucose uptake into muscle in addition to patterns observed in insulin signaling elements and FAS expression in adipose tissue. Though optimal macronutrient content remains unknown, increases in physiologic ranges of CARB in the diet produce huge shifts in metabolism while maintaining glucose homeostasis. (Abstract shortened by UMI.).","Made available in DSpace on 2015-09-25T22:31:09Z (GMT). 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