{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/84948"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/84948","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Intestinal Development and Gene Expression of Piglets Suckling Sows Transgenic for Human Insulin-Like Growth Factor-I","abstract":"We have shown that piglets suckling IGF exhibit structural and functional changes similar to those observed in piglets receiving formula supplemented with IGF-I. The location and timing of the response to IGF-I differs from previous studies. Insulin like growth factor-I appeared to act via the type I IGF receptor at d 21 in the ileum of piglets suckling IGF. Microarray analysis elucidated differentially expressed genes involved in proliferation, as well as genes involved in immune function and metabolism, suggesting new avenues for IGF-I research.","abstract_html":"We have shown that piglets suckling IGF exhibit structural and functional changes similar to those observed in piglets receiving formula supplemented with IGF-I. The location and timing of the response to IGF-I differs from previous studies. Insulin like growth factor-I appeared to act via the type I IGF receptor at d 21 in the ileum of piglets suckling IGF. Microarray analysis elucidated differentially expressed genes involved in proliferation, as well as genes involved in immune function and metabolism, suggesting new avenues for IGF-I research.","abstract_has_math":false,"creators":["Hartke, Jessica L."],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Nutritional Sciences","degree_department":null,"school":null,"contributors":["Donovan, Sharon M."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-25T22:31:06Z","date_published":"2015-09-25T22:31:06Z","updated_at":"2026-07-22T22:26:24Z","subjects":["Health Sciences, Nutrition"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(MiAaPQ)AAI3242863"],"render_values":[{"text":"(MiAaPQ)AAI3242863","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/84948","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Donovan, Sharon M."]},{"key":"dc:creator","label":"Author","values":["Hartke, Jessica L."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-09-25T22:31:06Z","10000-01-01","2006"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Nutritional Sciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Health Sciences, Nutrition"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/84948","(MiAaPQ)AAI3242863"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["We have shown that piglets suckling IGF exhibit structural and functional changes similar to those observed in piglets receiving formula supplemented with IGF-I. 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