{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/84849"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/84849","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Steroid Hormone and Growth Factor Regulation of Peripheral Myelination","abstract":"In addition to steroid hormones, signaling by platelet-derived growth factor (PDGF)-A in peripheral myelination was investigated. Lower levels of P0 were found in the developing sciatic nerve of PDGF-A null transgenic mice, especially when active myelin synthesis occurs. Morphological deformities of the myelin sheath were also observed in the sciatic nerve of the null mice. Furthermore, cocultures established with DRG neurons and Schwann cells from the null mice showed decreased expression of myelin basic protein (MBP) transcripts. PDGF-A null Schwann cells differentiating into the myelinating phenotype without neurons expressed lower levels of MBP and 3beta-hydroxysteroid dehydrogenase mRNAs and produced less progesterone and its metabolites. Treatment of the differentiating Schwann cells with PDGF-A increased the expression of MBP and the production of progesterone and its metabolites. Together, these results shed light on the importance of steroid hormones, growth factors, and their interaction in the process of myelin synthesis in the peripheral nervous system.","abstract_html":"In addition to steroid hormones, signaling by platelet-derived growth factor (PDGF)-A in peripheral myelination was investigated. Lower levels of P0 were found in the developing sciatic nerve of PDGF-A null transgenic mice, especially when active myelin synthesis occurs. Morphological deformities of the myelin sheath were also observed in the sciatic nerve of the null mice. Furthermore, cocultures established with DRG neurons and Schwann cells from the null mice showed decreased expression of myelin basic protein (MBP) transcripts. PDGF-A null Schwann cells differentiating into the myelinating phenotype without neurons expressed lower levels of MBP and 3beta-hydroxysteroid dehydrogenase mRNAs and produced less progesterone and its metabolites. Treatment of the differentiating Schwann cells with PDGF-A increased the expression of MBP and the production of progesterone and its metabolites. Together, these results shed light on the importance of steroid hormones, growth factors, and their interaction in the process of myelin synthesis in the peripheral nervous system.","abstract_has_math":false,"creators":["Thu, Thant Si"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Biochemistry","degree_department":null,"school":null,"contributors":["Glaser, Michael"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-25T22:28:11Z","date_published":"2015-09-25T22:28:11Z","updated_at":"2026-07-22T22:26:24Z","subjects":["Biology, Molecular"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(MiAaPQ)AAI3301235"],"render_values":[{"text":"(MiAaPQ)AAI3301235","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/84849","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Glaser, Michael"]},{"key":"dc:creator","label":"Author","values":["Thu, Thant Si"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-09-25T22:28:11Z","10000-01-01","2007"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Biochemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology, Molecular"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/84849","(MiAaPQ)AAI3301235"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["In addition to steroid hormones, signaling by platelet-derived growth factor (PDGF)-A in peripheral myelination was investigated. Lower levels of P0 were found in the developing sciatic nerve of PDGF-A null transgenic mice, especially when active myelin synthesis occurs. Morphological deformities of the myelin sheath were also observed in the sciatic nerve of the null mice. Furthermore, cocultures established with DRG neurons and Schwann cells from the null mice showed decreased expression of myelin basic protein (MBP) transcripts. PDGF-A null Schwann cells differentiating into the myelinating phenotype without neurons expressed lower levels of MBP and 3beta-hydroxysteroid dehydrogenase mRNAs and produced less progesterone and its metabolites. Treatment of the differentiating Schwann cells with PDGF-A increased the expression of MBP and the production of progesterone and its metabolites. Together, these results shed light on the importance of steroid hormones, growth factors, and their interaction in the process of myelin synthesis in the peripheral nervous system.","Made available in DSpace on 2015-09-25T22:28:11Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3301235.pdf: 4574288 bytes, checksum: 25d4dd4adfb1a40833e99e58acbbf98d (MD5) Previous issue date: 2007","Embargo set by: Seth Robbins for item 86130 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","159 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2007."]},{"key":"dc:title","label":"Title","values":["Steroid Hormone and Growth Factor Regulation of Peripheral Myelination"]}]}],"canonical_facts":{"dc:contributor":["Glaser, Michael"],"dc:creator":["Thu, Thant Si"],"dc:date":["2015-09-25T22:28:11Z","10000-01-01","2007"],"dc:description":["In addition to steroid hormones, signaling by platelet-derived growth factor (PDGF)-A in peripheral myelination was investigated. Lower levels of P0 were found in the developing sciatic nerve of PDGF-A null transgenic mice, especially when active myelin synthesis occurs. Morphological deformities of the myelin sheath were also observed in the sciatic nerve of the null mice. Furthermore, cocultures established with DRG neurons and Schwann cells from the null mice showed decreased expression of myelin basic protein (MBP) transcripts. PDGF-A null Schwann cells differentiating into the myelinating phenotype without neurons expressed lower levels of MBP and 3beta-hydroxysteroid dehydrogenase mRNAs and produced less progesterone and its metabolites. Treatment of the differentiating Schwann cells with PDGF-A increased the expression of MBP and the production of progesterone and its metabolites. 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