Transcriptional Regulation of the Bacillus Subtilis pyrG Gene Encoding Cytidine Triphosphate Synthetase
I propose that a trans-acting regulatory protein binds to the pyrG GGGC and GCUCCC sequences when intracellular CTP levels are low, which prevents the formation of the terminator and permits transcription readthrough. When intracellular CTP levels are high, I propose the regulatory protein dissociates from the pyrG leader RNA thereby allowing terminator formation and transcription termination.
University of Illinois - Urbana-Champaign
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University of Illinois at Urbana-Champaign