{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/84493"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/84493","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Chiral Homoenolate Synthetic Equivalents: Mechanistic, Structural, and Kinetic Investigations","abstract":"The lithiation of N-Boc-N-( p-methoxyphenyl)-3-cyclohexylallylamine by n-BuLi/(-)-sparteine was examined kinetically by means of in situ infrared spectroscopy. The reaction is first order in allylic amine and zero-order in 1:1 base/ligand complex. When the relative concentrations of n-BuLi and (-)-sparteine are not held constant, the reaction exhibits an inverse dependence on n-BuLi concentration. The experimental results are rationalized by a generalized mechanism that is consistent with thermodynamic parameters, an extremely high isotope effect, and computer simulations.","abstract_html":"The lithiation of N-Boc-N-( p-methoxyphenyl)-3-cyclohexylallylamine by n-BuLi/(-)-sparteine was examined kinetically by means of in situ infrared spectroscopy. The reaction is first order in allylic amine and zero-order in 1:1 base/ligand complex. When the relative concentrations of n-BuLi and (-)-sparteine are not held constant, the reaction exhibits an inverse dependence on n-BuLi concentration. The experimental results are rationalized by a generalized mechanism that is consistent with thermodynamic parameters, an extremely high isotope effect, and computer simulations.","abstract_has_math":false,"creators":["Pippel, Daniel James"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Beak, Peter"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-25T22:14:48Z","date_published":"2015-09-25T22:14:48Z","updated_at":"2026-07-22T22:26:23Z","subjects":["Chemistry, Organic"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(MiAaPQ)AAI9990108"],"render_values":[{"text":"(MiAaPQ)AAI9990108","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/84493","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Beak, Peter"]},{"key":"dc:creator","label":"Author","values":["Pippel, Daniel James"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-09-25T22:14:48Z","10000-01-01","2000"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Chemistry, Organic"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/84493","(MiAaPQ)AAI9990108"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The lithiation of N-Boc-N-( p-methoxyphenyl)-3-cyclohexylallylamine by n-BuLi/(-)-sparteine was examined kinetically by means of in situ infrared spectroscopy. The reaction is first order in allylic amine and zero-order in 1:1 base/ligand complex. When the relative concentrations of n-BuLi and (-)-sparteine are not held constant, the reaction exhibits an inverse dependence on n-BuLi concentration. The experimental results are rationalized by a generalized mechanism that is consistent with thermodynamic parameters, an extremely high isotope effect, and computer simulations.","Made available in DSpace on 2015-09-25T22:14:48Z (GMT). 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The reaction is first order in allylic amine and zero-order in 1:1 base/ligand complex. When the relative concentrations of n-BuLi and (-)-sparteine are not held constant, the reaction exhibits an inverse dependence on n-BuLi concentration. The experimental results are rationalized by a generalized mechanism that is consistent with thermodynamic parameters, an extremely high isotope effect, and computer simulations.","Made available in DSpace on 2015-09-25T22:14:48Z (GMT). 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