{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/84403"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/84403","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Synthetic Studies in the Didemnin Series","abstract":"Semi-synthetic studies directed toward didemnin analogues in which structural modifications were introduced in the side chain for investigating structure-activity relationships have been performed. The syntheses of several known didemnins including didemnin M, dehydrodidemnin B, and pyroglutamyl didemnin B have been successfully completed. In addition, several new didemnin analogues have been synthesized including glutaminyl didemnin B, (Ala$\\sp3$) didemnin B, (Ala$\\sp3$) didemnin M, and various other alaninyl derivatives. A total of forty didemnin analogues (thirty-four of which are new) were prepared semi-synthetically. In vitro cytotoxicity, antiviral activity, and structure-activity relationships for the above compounds are reported. Both glutaminyldidemnin B and (Ala$\\sp3$) didemnin B show significantly greater activity against L1210 cells (murine leukemia) than the natural source of didemnin B.","abstract_html":"Semi-synthetic studies directed toward didemnin analogues in which structural modifications were introduced in the side chain for investigating structure-activity relationships have been performed. The syntheses of several known didemnins including didemnin M, dehydrodidemnin B, and pyroglutamyl didemnin B have been successfully completed. In addition, several new didemnin analogues have been synthesized including glutaminyl didemnin B, (Ala$\\sp3$) didemnin B, (Ala$\\sp3$) didemnin M, and various other alaninyl derivatives. A total of forty didemnin analogues (thirty-four of which are new) were prepared semi-synthetically. In vitro cytotoxicity, antiviral activity, and structure-activity relationships for the above compounds are reported. Both glutaminyldidemnin B and (Ala$\\sp3$) didemnin B show significantly greater activity against L1210 cells (murine leukemia) than the natural source of didemnin B.","abstract_has_math":true,"creators":["Sanborn, Alexandra Jan"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Rinehart, Kenneth L., Jr."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-25T22:14:18Z","date_published":"2015-09-25T22:14:18Z","updated_at":"2026-07-22T22:26:23Z","subjects":["Health Sciences, Pharmacology"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(MiAaPQ)AAI9834737"],"render_values":[{"text":"(MiAaPQ)AAI9834737","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/84403","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Rinehart, Kenneth L., Jr."]},{"key":"dc:creator","label":"Author","values":["Sanborn, Alexandra Jan"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-09-25T22:14:18Z","10000-01-01","1998"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Health Sciences, Pharmacology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/84403","(MiAaPQ)AAI9834737"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Semi-synthetic studies directed toward didemnin analogues in which structural modifications were introduced in the side chain for investigating structure-activity relationships have been performed. The syntheses of several known didemnins including didemnin M, dehydrodidemnin B, and pyroglutamyl didemnin B have been successfully completed. In addition, several new didemnin analogues have been synthesized including glutaminyl didemnin B, (Ala$\\sp3$) didemnin B, (Ala$\\sp3$) didemnin M, and various other alaninyl derivatives. A total of forty didemnin analogues (thirty-four of which are new) were prepared semi-synthetically. In vitro cytotoxicity, antiviral activity, and structure-activity relationships for the above compounds are reported. Both glutaminyldidemnin B and (Ala$\\sp3$) didemnin B show significantly greater activity against L1210 cells (murine leukemia) than the natural source of didemnin B.","Made available in DSpace on 2015-09-25T22:14:18Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 9834737.pdf: 12250669 bytes, checksum: 717cd6b0089fab89c9847dc0be77b7e7 (MD5) Previous issue date: 1998","Embargo set by: Seth Robbins for item 85684 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","413 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1998."]},{"key":"dc:title","label":"Title","values":["Synthetic Studies in the Didemnin Series"]}]}],"canonical_facts":{"dc:contributor":["Rinehart, Kenneth L., Jr."],"dc:creator":["Sanborn, Alexandra Jan"],"dc:date":["2015-09-25T22:14:18Z","10000-01-01","1998"],"dc:description":["Semi-synthetic studies directed toward didemnin analogues in which structural modifications were introduced in the side chain for investigating structure-activity relationships have been performed. The syntheses of several known didemnins including didemnin M, dehydrodidemnin B, and pyroglutamyl didemnin B have been successfully completed. In addition, several new didemnin analogues have been synthesized including glutaminyl didemnin B, (Ala$\\sp3$) didemnin B, (Ala$\\sp3$) didemnin M, and various other alaninyl derivatives. A total of forty didemnin analogues (thirty-four of which are new) were prepared semi-synthetically. In vitro cytotoxicity, antiviral activity, and structure-activity relationships for the above compounds are reported. Both glutaminyldidemnin B and (Ala$\\sp3$) didemnin B show significantly greater activity against L1210 cells (murine leukemia) than the natural source of didemnin B.","Made available in DSpace on 2015-09-25T22:14:18Z (GMT). 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