Synthesis and Biological Evaluation of Coactivator Binding Inhibitors and Bivalent Ligands for the Estrogen Receptor
type: CreativeWork
description: The synthesis of steroidal bivalent ligands for ER is also reported. Two estradiol molecules were connected through a phenylethynyl linkage with chemical tethers of varying composition and length. The binding properties of the bivalent ligands for ER were measured. Moderate relative binding affinities were obtained and in some cases biphasic binding curves were observed.
abstract: The synthesis of steroidal bivalent ligands for ER is also reported. Two estradiol molecules were connected through a phenylethynyl linkage with chemical tethers of varying composition and length. The binding properties of the bivalent ligands for ER were measured. Moderate relative binding affinities were obtained and in some cases biphasic binding curves were observed.
author: LaFrate, Andrew
language: eng
keywords: Health Sciences, Oncology
date published: 2015-09-25T22:13:55Z
date modified: 2026-07-22T22:26:23Z
provider: University of Illinois - Urbana-Champaign
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of Illinois at Urbana-Champaign

PropertyValue
property ID: Handle
value: http://hdl.handle.net/2142/84316