{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/84281"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/84281","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Investigation of Phospholipid Bilayer Interactions With Substrates, Polymers, and Nanoparticles","abstract":"The last experiments described investigate the ability of water dispersed fullerene aggregates to interact with and disrupt cell membranes. Bilayers composed of both neat zwitterionic lipid headgroups and cationic lipid headgroups were examined to investigate charge interactions between the lipid headgroups and negatively charged fullerene aggregates. Our results indicate that water soluble fullerenes adhere to lipid headgroups and may disrupt cellular functions by either radical generation or cell membrane passivition.","abstract_html":"The last experiments described investigate the ability of water dispersed fullerene aggregates to interact with and disrupt cell membranes. Bilayers composed of both neat zwitterionic lipid headgroups and cationic lipid headgroups were examined to investigate charge interactions between the lipid headgroups and negatively charged fullerene aggregates. Our results indicate that water soluble fullerenes adhere to lipid headgroups and may disrupt cellular functions by either radical generation or cell membrane passivition.","abstract_has_math":false,"creators":["Spurlin, Tighe A."],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Gewirth, Andrew A."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-25T22:13:46Z","date_published":"2015-09-25T22:13:46Z","updated_at":"2026-07-22T22:26:22Z","subjects":["Chemistry, Analytical"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(MiAaPQ)AAI3290388"],"render_values":[{"text":"(MiAaPQ)AAI3290388","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/84281","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Gewirth, Andrew A."]},{"key":"dc:creator","label":"Author","values":["Spurlin, Tighe A."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-09-25T22:13:46Z","10000-01-01","2007"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Chemistry, Analytical"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/84281","(MiAaPQ)AAI3290388"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The last experiments described investigate the ability of water dispersed fullerene aggregates to interact with and disrupt cell membranes. Bilayers composed of both neat zwitterionic lipid headgroups and cationic lipid headgroups were examined to investigate charge interactions between the lipid headgroups and negatively charged fullerene aggregates. Our results indicate that water soluble fullerenes adhere to lipid headgroups and may disrupt cellular functions by either radical generation or cell membrane passivition.","Made available in DSpace on 2015-09-25T22:13:46Z (GMT). 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