{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/84234"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/84234","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Aminocyclodextrin Ion Channels: Development of a Model for Ligand Gating and Investigations of the Effects of Channel Structure on *Transport Properties and Ion Selectivity","abstract":"While it was previously shown that a heptaaminopentabutylene glycol beta-cyclodextrin ion channel was highly active and selectively transported anions, the requirements for the number of aminopentabutylene glycol substitutions were not known. beta-Cyclodextrin channels with four and two aminopentabutylene glycol chains and beta-cyclodextrins substituted with a glycine-pentabutylene glycol conjugate were synthesized. Their ion transport properties were assessed with a fluorescence assay using the pH sensitive dye HPTS. The amino acid containing channel showed little activity, while the di- and tetraamino channels showed increasing activity with increasing substitution. The tetraamino channel showed selectivity for anion transport that followed the trend ClO4- > I- > NO3- > Br- > Cl-. The preferences for ClO4-, I-, NO3-, and Br- transport were roughly 32, 16, 7, and 2 times that of Na+, respectively. The rate of transport of Cl- was roughly equivalent to the rate of Na + transport.","abstract_html":"While it was previously shown that a heptaaminopentabutylene glycol beta-cyclodextrin ion channel was highly active and selectively transported anions, the requirements for the number of aminopentabutylene glycol substitutions were not known. beta-Cyclodextrin channels with four and two aminopentabutylene glycol chains and beta-cyclodextrins substituted with a glycine-pentabutylene glycol conjugate were synthesized. Their ion transport properties were assessed with a fluorescence assay using the pH sensitive dye HPTS. The amino acid containing channel showed little activity, while the di- and tetraamino channels showed increasing activity with increasing substitution. The tetraamino channel showed selectivity for anion transport that followed the trend ClO4- > I- > NO3- > Br- > Cl-. The preferences for ClO4-, I-, NO3-, and Br- transport were roughly 32, 16, 7, and 2 times that of Na+, respectively. The rate of transport of Cl- was roughly equivalent to the rate of Na + transport.","abstract_has_math":false,"creators":["Sanders, Rachel Sarah"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Mary S. Gin"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-25T22:13:35Z","date_published":"2015-09-25T22:13:35Z","updated_at":"2026-07-22T22:26:22Z","subjects":["Chemistry, Organic"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(MiAaPQ)AAI3223711"],"render_values":[{"text":"(MiAaPQ)AAI3223711","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/84234","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Mary S. 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Their ion transport properties were assessed with a fluorescence assay using the pH sensitive dye HPTS. The amino acid containing channel showed little activity, while the di- and tetraamino channels showed increasing activity with increasing substitution. The tetraamino channel showed selectivity for anion transport that followed the trend ClO4- > I- > NO3- > Br- > Cl-. The preferences for ClO4-, I-, NO3-, and Br- transport were roughly 32, 16, 7, and 2 times that of Na+, respectively. The rate of transport of Cl- was roughly equivalent to the rate of Na + transport.","Made available in DSpace on 2015-09-25T22:13:35Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3223711.pdf: 3380590 bytes, checksum: c3741995673e228bea1bb7c8950a44e6 (MD5) Previous issue date: 2006","Embargo set by: Seth Robbins for item 85515 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","155 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2006."]},{"key":"dc:title","label":"Title","values":["Aminocyclodextrin Ion Channels: Development of a Model for Ligand Gating and Investigations of the Effects of Channel Structure on *Transport Properties and Ion Selectivity"]}]}],"canonical_facts":{"dc:contributor":["Mary S. Gin"],"dc:creator":["Sanders, Rachel Sarah"],"dc:date":["2015-09-25T22:13:35Z","10000-01-01","2006"],"dc:description":["While it was previously shown that a heptaaminopentabutylene glycol beta-cyclodextrin ion channel was highly active and selectively transported anions, the requirements for the number of aminopentabutylene glycol substitutions were not known. beta-Cyclodextrin channels with four and two aminopentabutylene glycol chains and beta-cyclodextrins substituted with a glycine-pentabutylene glycol conjugate were synthesized. Their ion transport properties were assessed with a fluorescence assay using the pH sensitive dye HPTS. The amino acid containing channel showed little activity, while the di- and tetraamino channels showed increasing activity with increasing substitution. The tetraamino channel showed selectivity for anion transport that followed the trend ClO4- > I- > NO3- > Br- > Cl-. The preferences for ClO4-, I-, NO3-, and Br- transport were roughly 32, 16, 7, and 2 times that of Na+, respectively. The rate of transport of Cl- was roughly equivalent to the rate of Na + transport.","Made available in DSpace on 2015-09-25T22:13:35Z (GMT). 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