{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/84201"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/84201","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"An Improved Understanding of Bisphosphonates Through Computational Techniques","abstract":"A number of bisphosphonates are currently used to treat human bone resorption disorders. In recent years, these compounds have been shown to have additional biological properties, such as the ability to inhibit the growth of parasite cells and the ability to stimulate human gammadelta T cells. We have used computational techniques, such as CoMSIA and pharmacophore modeling, together with experimental data, to explain these secondary activities. In addition, this work has led to the discovery of new, highly-potent bisphosphonates, which could be useful in the treatment of human bone resorption diseases, parasitic diseases, and in the immunotherapeutic treatment of some diseases, such as cancer.","abstract_html":"A number of bisphosphonates are currently used to treat human bone resorption disorders. In recent years, these compounds have been shown to have additional biological properties, such as the ability to inhibit the growth of parasite cells and the ability to stimulate human gammadelta T cells. We have used computational techniques, such as CoMSIA and pharmacophore modeling, together with experimental data, to explain these secondary activities. In addition, this work has led to the discovery of new, highly-potent bisphosphonates, which could be useful in the treatment of human bone resorption diseases, parasitic diseases, and in the immunotherapeutic treatment of some diseases, such as cancer.","abstract_has_math":false,"creators":["Sanders, John"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Oldfield, Eric"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-25T22:13:27Z","date_published":"2015-09-25T22:13:27Z","updated_at":"2026-07-22T22:26:22Z","subjects":["Chemistry, Pharmaceutical"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(MiAaPQ)AAI3199132"],"render_values":[{"text":"(MiAaPQ)AAI3199132","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/84201","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Oldfield, Eric"]},{"key":"dc:creator","label":"Author","values":["Sanders, John"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-09-25T22:13:27Z","10000-01-01","2005"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Chemistry, Pharmaceutical"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/84201","(MiAaPQ)AAI3199132"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["A number of bisphosphonates are currently used to treat human bone resorption disorders. In recent years, these compounds have been shown to have additional biological properties, such as the ability to inhibit the growth of parasite cells and the ability to stimulate human gammadelta T cells. We have used computational techniques, such as CoMSIA and pharmacophore modeling, together with experimental data, to explain these secondary activities. In addition, this work has led to the discovery of new, highly-potent bisphosphonates, which could be useful in the treatment of human bone resorption diseases, parasitic diseases, and in the immunotherapeutic treatment of some diseases, such as cancer.","Made available in DSpace on 2015-09-25T22:13:27Z (GMT). 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In recent years, these compounds have been shown to have additional biological properties, such as the ability to inhibit the growth of parasite cells and the ability to stimulate human gammadelta T cells. We have used computational techniques, such as CoMSIA and pharmacophore modeling, together with experimental data, to explain these secondary activities. In addition, this work has led to the discovery of new, highly-potent bisphosphonates, which could be useful in the treatment of human bone resorption diseases, parasitic diseases, and in the immunotherapeutic treatment of some diseases, such as cancer.","Made available in DSpace on 2015-09-25T22:13:27Z (GMT). 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