{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/84196"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/84196","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Design and Synthesis of Novel Core Scaffolds for the Development of Subtype Selective Estrogen Receptor Ligands","abstract":"The Estrogen Receptor (ER) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily which plays a crucial role in bone maintenance, cardiovascular function and reproductive processes in both men and women. Although the two subtypes of ER---ERalpha and ERbeta---share 96% homology in their DNA-binding domains, their ligand-binding domains share only 59% homology, allowing for the design of subtype-specific or selective estrogen receptor modulators commonly known as SERMs. We describe herein the design and synthesis of novel sulfonamide and spirocyclohexadienonyl systems for use as potential selective estrogen receptor modulators.","abstract_html":"The Estrogen Receptor (ER) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily which plays a crucial role in bone maintenance, cardiovascular function and reproductive processes in both men and women. Although the two subtypes of ER---ERalpha and ERbeta---share 96% homology in their DNA-binding domains, their ligand-binding domains share only 59% homology, allowing for the design of subtype-specific or selective estrogen receptor modulators commonly known as SERMs. We describe herein the design and synthesis of novel sulfonamide and spirocyclohexadienonyl systems for use as potential selective estrogen receptor modulators.","abstract_has_math":false,"creators":["Miller, Lynne A."],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Katzenellenbogen, John A."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-25T22:13:25Z","date_published":"2015-09-25T22:13:25Z","updated_at":"2026-07-22T22:26:22Z","subjects":["Chemistry, Pharmaceutical"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(MiAaPQ)AAI3199088"],"render_values":[{"text":"(MiAaPQ)AAI3199088","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/84196","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Katzenellenbogen, John A."]},{"key":"dc:creator","label":"Author","values":["Miller, Lynne A."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-09-25T22:13:25Z","10000-01-01","2005"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Chemistry, Pharmaceutical"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/84196","(MiAaPQ)AAI3199088"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The Estrogen Receptor (ER) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily which plays a crucial role in bone maintenance, cardiovascular function and reproductive processes in both men and women. Although the two subtypes of ER---ERalpha and ERbeta---share 96% homology in their DNA-binding domains, their ligand-binding domains share only 59% homology, allowing for the design of subtype-specific or selective estrogen receptor modulators commonly known as SERMs. We describe herein the design and synthesis of novel sulfonamide and spirocyclohexadienonyl systems for use as potential selective estrogen receptor modulators.","Made available in DSpace on 2015-09-25T22:13:25Z (GMT). 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Although the two subtypes of ER---ERalpha and ERbeta---share 96% homology in their DNA-binding domains, their ligand-binding domains share only 59% homology, allowing for the design of subtype-specific or selective estrogen receptor modulators commonly known as SERMs. We describe herein the design and synthesis of novel sulfonamide and spirocyclohexadienonyl systems for use as potential selective estrogen receptor modulators.","Made available in DSpace on 2015-09-25T22:13:25Z (GMT). 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