{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/84167"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/84167","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Mechanism of the Neural Cell Adhesion Molecule and Mode of Polysialic Acid Adhesive Inhibition","abstract":"Lastly, direct force measurements are presented on polysialylated NCAM proteins to determine the effects of polysialic acid on both NCAM and C-cadherin mediated adhesion. Results indicate that polysialic acid inhibits both NCAM and cadherin adhesion by increasing the intermembrane repulsion. This inhibitory effect was dependant on both polysialic acid surface density and on ionic strength.","abstract_html":"Lastly, direct force measurements are presented on polysialylated NCAM proteins to determine the effects of polysialic acid on both NCAM and C-cadherin mediated adhesion. Results indicate that polysialic acid inhibits both NCAM and cadherin adhesion by increasing the intermembrane repulsion. This inhibitory effect was dependant on both polysialic acid surface density and on ionic strength.","abstract_has_math":false,"creators":["Johnson, Colin"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Leckband, Deborah E."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-25T22:13:17Z","date_published":"2015-09-25T22:13:17Z","updated_at":"2026-07-22T22:26:22Z","subjects":["Biology, Cell"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(MiAaPQ)AAI3160898"],"render_values":[{"text":"(MiAaPQ)AAI3160898","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/84167","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Leckband, Deborah E."]},{"key":"dc:creator","label":"Author","values":["Johnson, Colin"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-09-25T22:13:17Z","10000-01-01","2004"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology, Cell"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/84167","(MiAaPQ)AAI3160898"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Lastly, direct force measurements are presented on polysialylated NCAM proteins to determine the effects of polysialic acid on both NCAM and C-cadherin mediated adhesion. Results indicate that polysialic acid inhibits both NCAM and cadherin adhesion by increasing the intermembrane repulsion. This inhibitory effect was dependant on both polysialic acid surface density and on ionic strength.","Made available in DSpace on 2015-09-25T22:13:17Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3160898.pdf: 5776564 bytes, checksum: df4dfc49c95dee0d2fa3871ae0423dd5 (MD5) Previous issue date: 2004","Embargo set by: Seth Robbins for item 85448 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","143 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2004."]},{"key":"dc:title","label":"Title","values":["Mechanism of the Neural Cell Adhesion Molecule and Mode of Polysialic Acid Adhesive Inhibition"]}]}],"canonical_facts":{"dc:contributor":["Leckband, Deborah E."],"dc:creator":["Johnson, Colin"],"dc:date":["2015-09-25T22:13:17Z","10000-01-01","2004"],"dc:description":["Lastly, direct force measurements are presented on polysialylated NCAM proteins to determine the effects of polysialic acid on both NCAM and C-cadherin mediated adhesion. Results indicate that polysialic acid inhibits both NCAM and cadherin adhesion by increasing the intermembrane repulsion. This inhibitory effect was dependant on both polysialic acid surface density and on ionic strength.","Made available in DSpace on 2015-09-25T22:13:17Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3160898.pdf: 5776564 bytes, checksum: df4dfc49c95dee0d2fa3871ae0423dd5 (MD5) Previous issue date: 2004","Embargo set by: Seth Robbins for item 85448 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","143 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2004."],"dc:identifier":["http://hdl.handle.net/2142/84167","(MiAaPQ)AAI3160898"],"dc:language":["eng"],"dc:subject":["Biology, Cell"],"dc:title":["Mechanism of the Neural Cell Adhesion Molecule and Mode of Polysialic Acid Adhesive Inhibition"],"dc:type":["text"],"thesis:degree_discipline":["Chemistry"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:26:22Z"}